Results 121 to 130 of about 102,629 (199)
Iron oxide nanoparticles and induced autophagy in human monocytes
, 2017 QiHong Wu,1 RongRong Jin,2 Ting Feng,1 Li Liu,2 Li Yang,2 YuHong Tao,3 James M Anderson,4,5 Hua Ai,2,6 Hong Li1,3 1Key Laboratory of Obstetrics, Gynecology, Pediatric Disease, and Birth Defects, Ministry of Education, West China Second University ...
Anderson JM +8 more
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Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal
Advanced Science, EarlyView.We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao +7 more
wiley +1 more source
Advanced Science, EarlyView.Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li +6 more
wiley +1 more source
Role of monocytes in cancer progression (an in vitro approach)
reservedMacrophages, predominantly derived from highly plastic circulating monocytes, constitute one of the first line of defense against exogenous and endogenous threats.
DAL ZOVO, ERICA
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Pin1-mediated prolyl isomerization of Runx1 affects PU.1 expression in pre-monocytes
, 2014 Regulation of the hematopoietic transcription factor PU.1, a member of the ETS family, plays a critical role in the development of blood cells and in leukemia. The dosage of PU.1 has been shown to cause a shift in myelomonocytic progenitor fate.
J-H Baek (13628332) +4 more
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CSF-1 as a regulator of macrophage activation and immune responses [PDF]
, 2003 Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases. The extent of macrophage activation is tightly regulated by a number of pro-inflammatory cytokines (e.g.
Sweet, MJ +3 more
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Advanced Science, EarlyView.Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu +7 more
wiley +1 more source
Advanced Science, EarlyView.Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta +10 more
wiley +1 more source
Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis
Advanced Science, EarlyView.Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun +10 more
wiley +1 more source
Кубанский научный медицинский вестник, 2016 Comparative evaluation of character of the expression of TLR9 and CD11b receptors by neutrophilic granulocytes and monocytes whole blood under the influence of Derinat and synthetic TLR9 ligand in healthy individuals and in acute infectious diseases of ...
T. V. Rusinova +2 more
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