Results 141 to 150 of about 419,171 (259)

P-Selectin and Platelet-Monocyte Interaction in Inflammation: Mechanisms, Hypothesis, and Open Questions. [PDF]

J Inflamm Res
Fernandes MKC, De Paula MML, Oliveira RTR, Dos Santos JPRS, Mancini MCB, Hottz ED.   +5 more
europepmc   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source

The transcriptome of CD14⁺CD163^-HLA-DR^low monocytes predicts mortality in idiopathic pulmonary fibrosis. [PDF]

Eur Respir J
Karampitsakos T, Jia M, Tourki B, Fatima Z, Visinescu B, Perrot CY, Fadli T, Zhao A, Unterman A, Schneider MA, Bandyopadhyay D, Juan-Guardela BM, Vamvakaris I, Prasse A, Noth I, Liggett S, Kreuter M, Drake W, Tzouvelekis A, Garcia JGN, Herzog E, Kaminski N, Benos PV, Herazo-Maya JD.   +23 more
europepmc   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosus. [PDF]

Front Immunol
Hernández-Ledesma AL, Coss-Navarrete EL, Salazar-Magaña S, Ramírez-Espinosa D, Tinajero-Nieto L, Torres-Valdez E, Peña-Ayala AH, Félix-Rodriguez G, Frontana-Vázquez G, García Sotelo JS, Thomas-Chollier M, Trynka G, Rosetti F, Fernandez-Valverde SL, Gutiérrez-Arcelus M, Alpízar-Rodríguez D, Medina-Rivera A.   +16 more
europepmc   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Opposing Association of Lung Neutrophils and PD-L1⁺ Monocytes in Age-Related Severity of SARS-CoV-2 Infection. [PDF]

Aging Cell
Morosan S, Granier C, Guillou N, Bennacer S, Weber-Delacroix E, Peronnet J, Lanthiez F, Barthelemy S, Enond C, Diehl JL, Paillaud E, El-Sissy C, Marcelin AG, Calvez V, Marot S, Guihot A, Parizot C, Dorgham K, Gorochov G, Combadière C, Boissonnas A.   +20 more
europepmc   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Characterizing the myeloid and lymphoid immune response in a porcine model of pulmonary ischemia-reperfusion injury through flow cytometry. [PDF]

PLoS One
Duong A, Mariscal A, Caldarone L, Xu C, Huang L, Ramendra R, Keshavjee S, Liu M, Juvet S, Martinu T.   +9 more
europepmc   +1 more source

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source