Results 131 to 140 of about 613,326 (371)

Model of pathogenesis of psoriasis. Part 1. Systemic psoriatic process [PDF]

arXiv, 2011
Analytical study of results of experimental and theoretical works on pathogenesis of psoriatic disease was conducted. Psoriasis is dermal implication of systemic psoriatic process (SPP). New SPP model explaining results of clinical and laboratory experiments was formulated.
arxiv  

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

Oncoimmunology, 2017
Exosomes can mediate a dynamic method of communication between malignancies, including those sequestered in the central nervous system and the immune system.
Konrad Gabrusiewicz, Xu Li, Jun Wei, Y. Hashimoto, Anantha L. Marisetty, Martina Ott, Fei Wang, D. Hawke, John Yu, Luke M. Healy, Anwar Hossain, J. Akers, S. Maiti, Shinji Yamashita, Yuzaburo Shimizu, K. Dunner, M. Zal, J. Burks, J. Gumin, Felix Nwajei, Aras Rezavanian, Shouhao Zhou, G. Rao, R. Sawaya, G. Fuller, J. Huse, J. Antel, Shulin Li, L. Cooper, E. Sulman, Clark C. Chen, C. Geula, R. Kalluri, T. Zal, A. Heimberger   +34 more
semanticscholar   +1 more source

Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang, Tian‐Xiang Zhang, Jia Liu, Zhirui Liu, Lijie Zhu, Yan‐Yan Li, Bin Feng, Moli Fan, Fu‐Dong Shi, Chao Zhang   +9 more
wiley   +1 more source

Monocytes conditioned media stimulate fibronectin expression and spreading of inflammatory breast cancer cells in three-dimensional culture: A mechanism mediated by IL-8 signaling pathway

Cell Communication and Signaling, 2012
Background Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer characterized by invasion of carcinoma cells into dermal lymphatic vessels where they form tumor emboli over expressing adhesion molecule E-cadherin.
Mohamed Mona M
doaj   +1 more source

Tumor-derived exosomes modulate PD-L1 expression in monocytes

Science immunology, 2017
Transfer of exosomal RNA from leukemic cells to monocytes induces immunosuppression. Messaging with RNAs Understanding interactions between tumor cells and immune cells is essential for tailoring immunocentric therapies to tumors.
Franziska Haderk, R. Schulz, M. Iskar, Laura Llaó Cid, T. Worst, Karolin V Willmund, A. Schulz, U. Warnken, J. Seiler, A. Benner, M. Nessling, T. Zenz, Maria Göbel, J. Dürig, S. Diederichs, J. Paggetti, E. Moussay, S. Stilgenbauer, M. Zapatka, P. Lichter, M. Seiffert   +20 more
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Variant assumptions made in deriving equilibrium solutions to Little et al (PLoS Comput Biol 2009 5(10) e1000539) [PDF]

arXiv, 2009
The paper of Little et al. (PloS Comput Biol 2009 5(10) e1000539) outlined a system of reaction-diffusion equations that were used to describe induction of atherosclerotic disease. These were solved by considering an equilibrium solution and small perturbations around this equilibrium.
arxiv  

STUDIES ON TUBERCLE BACILLUS-MONOCYTE RELATIONSHIP [PDF]

, 1957
Jacob Fong, Patricia Schneider, Sanford S. Elberg   +2 more
openalex   +1 more source

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Status epilepticus is a frequent neurological emergency. These unabated seizures reduce quality of life, promote the development of epilepsy, and can cause death.
Nicholas H Varvel, J. Neher, Andrea Bosch, Wenyi Wang, R. Ransohoff, Richard J. Miller, R. Dingledine   +6 more
semanticscholar   +1 more source

A Novel Protein‐Polysaccharide Oral Nanoemulsion Targeting Activated Hepatic Stellate Cells to Enhance the Therapeutic Effect of Pirfenidone on Fibrosis After Transarterial Chemoembolization for Liver Cancer

Advanced Functional Materials, EarlyView.
Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng, Shan Xu, Yi Lei, Huizhou He, Runbin Sun, Xingle Jin, Cheneryu Huang, Yuhao Zheng, Jianqing Peng, Lei Tang, Peng Luo, Yi Chen, Shuai Zhang   +12 more
wiley   +1 more source