Results 11 to 20 of about 405,184 (258)

Differentiation and subpopulation composition of VEGFR2+ cells in the blood and bone marrow in ischemic cardiomyopathy

open access: yesБюллетень сибирской медицины, 2022
Aim. To identify disturbances of differentiation and subpopulation composition of VEGFR2+ cells in the blood and bone marrow associated with the features of the cytokine profile in the blood and bone marrow in patients with coronary artery disease (CAD ...
S. P. Chumakova   +6 more
doaj   +1 more source

Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14+CD16− Monocytes

open access: yesFrontiers in Immunology, 2019
Monocytes in humans consist of 3 subsets; CD14+CD16− (classical), CD14+CD16+ (intermediate) and CD14dimCD16+ (non-classical), which exhibit distinct and heterogeneous responses to activation.
Man K. S. Lee   +16 more
doaj   +1 more source

The significance of M1/M2 macrophage-like monocytes in children with systemic lupus erythematosus

open access: yesEuropean Journal of Inflammation, 2019
Monocytes/macrophages are important in the development of systemic lupus erythematosus. To research M1 and M2 macrophage-like monocytes in the peripheral blood of children with systemic lupus erythematosus and explore the clinical significance, M1 and M2
Xiao-Ling Niu   +6 more
doaj   +1 more source

Immunophenotyping of circulating mononuclear cells in active pulmonary tuberculosis

open access: yesJournal of Infection in Developing Countries, 2018
Introduction: Interpreting the interactions between M. tuberculosis and the host innate and adaptive immune defense mechanisms is mandatory for understanding the pathogenesis of active pulmonary TB (APTB).
Amany Elkholy   +4 more
doaj   +1 more source

OPPORTUNITIES OF FLOW CYTOMETRY IN DIAGNOSTICS OF INFECTIOUS DISEASES. PART 1

open access: yesИнфекция и иммунитет, 2014
. Development of a modern medical science demands more thorough and deeper approach to diagnostics of diseases. New diagnostic technologies for these investigations are necessary and flow cytometry is such technology.
S. V. Khaidukov, A. V. Zurochka
doaj   +1 more source

Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ Responsiveness

open access: yesCells, 2020
COVID-19, caused by SARS-CoV-2 virus, emerged as a pandemic disease posing a severe threat to global health. To date, sporadic studies have demonstrated that innate immune mechanisms, specifically neutrophilia, NETosis, and neutrophil-associated cytokine
Zuzana Parackova   +9 more
doaj   +1 more source

Increasing the Magnesium Concentration in Various Dialysate Solutions Differentially Modulates Oxidative Stress in a Human Monocyte Cell Line

open access: yesAntioxidants, 2020
Oxidative stress is exacerbated in hemodialysis patients by several factors, including the uremic environment and the use of dialysis fluids (DFs). Since magnesium (Mg) plays a key role in modulating immune function and in reducing oxidative stress, we ...
Carmen Vida   +6 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Can Hematological Parameters be Used for Differential Diagnosis in Rotavirus Infection at any Age of Children? A 6-year Outcomes from a Tertiary Referral Center

open access: yesHaseki Tıp Bülteni, 2021
Aim:Routine blood parameters are widely used to detect of infectious diseases. Our study aimed to investigate the hematological parameters changes in rotavirus (RV) acute gastroenteritis and to evaluate the value of these parameters in children.Methods ...
Meliha Aksoy Okan   +3 more
doaj   +1 more source

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