Results 21 to 30 of about 419,171 (259)

The Flow Cytometry Study of Cellular Immunity in Rhesus Monkeys after Experimental Infection with SARS CoV 2 Virus

Проблемы особо опасных инфекций, 2022
Cellular immunity plays an important role in the pathogenesis and formation of protective immune defense against the SARS‑CoV‑2 virus.The aim of the work was to study the cellular immunity of rhesus monkeys applying flow cytometry after experimental ...
G. V. Borisevich, S. L. Kirillova, I. V. Shatokhina, V. N. Lebedev, S. S. Solov’ev, S. I. Syromyatnikova, N. V. Shagarova, N. V. Boyarskaya, N. G. Levkovich, D. A. Solyanik, A. F. Andrus, V. V. Rubtsov, V. T. Krotkov, V. S. Kulish, I. V. Surovyatkina, V. B. Kirillov, A. V. Koval’chuk, V. B. Pantyukhov, D. A. Kutaev, S. V. Borisevich   +19 more
doaj   +1 more source

Monocyte and Haemostasis

Hematology, 1998
Human monocytes may play a central role in haemostasis since they are the only circulating blood cells capable to express tissue factor (TF) and therefore trigger the extrinsic pathway of coagulation. The aim of this review is to illustrate that monocytes also participate in haemostasis independently of TF expression.
M, Broussas, P, Cornillet-Lefebvre, G, Potron, P, Nguyen   +3 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Can Hematological Parameters be Used for Differential Diagnosis in Rotavirus Infection at any Age of Children? A 6-year Outcomes from a Tertiary Referral Center

Haseki Tıp Bülteni, 2021
Aim:Routine blood parameters are widely used to detect of infectious diseases. Our study aimed to investigate the hematological parameters changes in rotavirus (RV) acute gastroenteritis and to evaluate the value of these parameters in children.Methods ...
Meliha Aksoy Okan, Hayrettin Temel, Mesut Okur, Ayse Istanbullu Tosun   +3 more
doaj   +1 more source

Monocytes in the Rat

Immunobiology, 2000
We review our methods for definition and phenotypical characterisation of normal and activated rat monocytes. To obtain a comprehensive sample of all blood monocytes including cells from the marginal pool of the blood stream, we extensively perfuse the extrapulmonary circulation with cold PBS/EDTA.
V, Grau, A, Scriba, O, Stehling, B, Steiniger   +3 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Interleukin-10 disrupts liver repair in acetaminophen-induced acute liver failure

Frontiers in Immunology, 2023
IntroductionSystemic levels of the anti-inflammatory cytokine interleukin 10 (IL-10) are highest in acetaminophen (APAP)-induced acute liver failure (ALF) patients with the poorest prognosis. The mechanistic basis for this counterintuitive finding is not
Katherine Roth, Katherine Roth, Katherine Roth, Katherine Roth, Jenna Strickland, Jenna Strickland, Jenna Strickland, Jenna Strickland, Asmita Pant, Robert Freeborn, Robert Freeborn, Rebekah Kennedy, Rebekah Kennedy, Cheryl E. Rockwell, Cheryl E. Rockwell, Cheryl E. Rockwell, Cheryl E. Rockwell, James P. Luyendyk, James P. Luyendyk, Bryan L. Copple, Bryan L. Copple, Bryan L. Copple, Bryan L. Copple   +22 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

TLRs1-10 Protein Expression in Circulating Human White Blood Cells during Bacterial and COVID-19 Infections

Journal of Innate Immunity
Introduction: Toll-like receptors play crucial roles in the sepsis-induced systemic inflammatory response. Septic shock mortality correlates with overexpression of neutrophilic TLR2 and TLR9, while the role of TLR4 overexpression remains a debate.
Louise Chomel, Mathieu Vogt, Julien Demiselle, Pierrick Le Borgne, Marine Tschirhart, Valentin Morandeau, Hamid Merdji, Laurent Miguet, Julie Helms, Ferhat Meziani, Laurent Mauvieux   +10 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source