Results 31 to 40 of about 102,629 (199)

Examination of the inflammatory nature of different placental syncytiotrophoblast microparticles (STBM) preparations on human monocytes [PDF]

, 2009
Background: Healthy human pregnancies are accompanied by a mild systemic maternal inflammatory response, which includes activation of peripheral blood monocytes.
Messerli, Marianne Simone
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Targeting Interactions between Fibroblasts and Macrophages to Treat Cardiac Fibrosis

Cells
Excessive extracellular matrix (ECM) deposition is a defining feature of cardiac fibrosis. Most notably, it is characterized by a significant change in the concentration and volume fraction of collagen I, a disproportionate deposition of collagen ...
Bo Yang, Yan Qiao, Dong Yan, Qinghang Meng   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. [PDF]

, 2015
Parasitic helminth infections can be associated with lifelong morbidity such as immune-mediated organ failure. A better understanding of the host immune response to helminths could provide new avenues to promote parasite clearance and/or alleviate ...
Josiah I. Chung, Nutman, Thomas B, Barnes, MA, Josiah I Chung, Chung, Josiah I, Cooper, Philip J, Meera G. Nair (285902), Josiah I. Chung (682394), Nair, Meera G, Gang Chen (107840), Thomas B. Nutman, Nair, MG, Mali Camberis, Le Gros, G, Graham Le Gros, Mark A. Barnes (682393), Thomas B. Nutman (113195), Le Gros, Graham, Steel, C, Mark A Barnes, Jessica C. Jang (682391), Mitchell A. Lazar, Camberis, M, Thomas B Nutman, Meera G. Nair, Cathy Steel (180788), Jang, JC, Meera G Nair, Graham Le Gros (682396), Cooper, PJ, Jessica C Jang, Spencer H. Wang, Lazar, MA, Mitchell A Lazar, Spencer H. Wang (682392), Lazar, Mitchell A, Mark A. Barnes, Chen, Gang, Camberis, Mali, Mitchell A. Lazar (27888), Wang, SH, Gang Chen, Barnes, Mark A, Chen, G, Spencer H Wang, Philip J. Cooper, Wang, Spencer H, Mali Camberis (682395), Philip J. Cooper (218309), Chung, JI, Nutman, TB, Cathy Steel, Jang, Jessica C, Philip J Cooper, Steel, Cathy, Jessica C. Jang   +55 more
core   +1 more source

Glucocorticoid boluses followed by tocilizumab in giant cell arteritis patients: effects on peripheral blood monocytes and lymphocytes

Frontiers in Immunology
IntroductionGiant Cell Arteritis (GCA) is the most common vasculitis in the elderly, characterized by granulomatous infiltration of immune cells in medium and large arteries.
Cecilia Catellani, Martina Bonacini, Alessandro Rossi, Ilaria Ferrigno, Ilaria Ferrigno, Veronica Buia, Chiara Marvisi, Chiara Marvisi, Giulia Cassone, Mariagrazia Catanoso, Gabriella Di Tommaso, Luigi Boiardi, Rexhep Durmo, Annibale Versari, Massimiliano Casali, Giulia Besutti, Giulia Besutti, Lucia Spaggiari, Alessandro Zerbini, Francesco Muratore, Francesco Muratore, Carlo Salvarani, Carlo Salvarani, Stefania Croci   +23 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation [PDF]

, 2012
Influenza virus infection accounts for significant morbidity and mortality world-wide. Interactions of the virus with host cells, particularly those of the macrophage lineage, are thought to contribute to various pathological changes associated with poor
Jackson David, Richard E. Randall, Richard E. Randall (190211), Nash, A.A., Anthony A Nash, Hoeve, M.A., Marieke A Hoeve, Anthony A. Nash, Hoeve Marieke A., Nash, Anthony A., Dransfield, I., Marieke A. Hoeve (190207), David Jackson (84936), Richard E Randall, Randall Richard E., Jackson, David, Randall, R.E., Nash Anthony A., David Jackson, Jackson, D., Ian Dransfield (190213), Dransfield, Ian, Marieke A. Hoeve, Anthony A. Nash (190209), Randall, Richard E., Ian Dransfield, Hoeve, Marieke A., Dransfield Ian   +27 more
core   +1 more source

Adipose inflammation: South Asian ethnicity and central obesity are independently associated with higher immune cell recruitment to adipose‐specific media: A pilot study in men

Physiological Reports, 2023
A South Asian (SA) cardiovascular phenomenon exists whereby SAs have excess burden of cardiovascular disease (CVD) despite having low prevalence of recognized CVD risk factors.
Matthew J. Roberts, Malik Hamrouni, Alex J. Wadley, Nicolette C. Bishop   +3 more
doaj   +1 more source