Results 91 to 100 of about 41,733 (199)

Supramolecular Polymer‐Surfactant Co‐Assemblies for Multivalent HSV‐1 Inhibition

Angewandte Chemie, EarlyView.
Non‐covalent co‐assembly of BTA with antiviral surfactants produces ratio‐dependent morphologies. Fibrous supramolecular polymers exhibit superior HSV‐1 inhibition, revealing multivalent fiber‐virus interactions and highlighting supramolecular co‐assemblies as a powerful strategy for functional biomedical nanomaterials with demonstrated tunable ...
Christian Zoister, Boris Schade, Paulina Sittinger, Xianwen Lou, Esmee de Korver, Freek V. de Graaf, Ranen Etouki, Chuanxiong Nie, Kai Licha, Kai Ludwig, Abhishek Kumar Singh, E. W. Meijer, Rainer Haag   +12 more
wiley   +2 more sources

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Electrochemically Triggered Supramolecular Polymerization Under Kinetic Control

Angewandte Chemie, EarlyView.
Chemical and electrochemical stimuli enable controlled supramolecular polymerization of perylene diimide–histidine (PDI–His). Redox processes mediate the transformation of kinetically trapped aggregates into thermodynamically stable nanofibers, thereby supporting seeded growth. This approach provides a strategy for regulating self‐assembly pathways and
Eun Gyu Lee, Jeongse Yun, Hyoung Wook Kang, Daeun Jung, Seung‐Ryong Kwon, Jong Hwa Jung, Sung Ho Jung   +6 more
wiley   +2 more sources

Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes

Mediators of Inflammation, 2015
C-reactive protein (CRP) is a pentraxin that has long been employed as a marker of inflammation in clinical practice. Recent findings brought up the idea of CRP to be not only a systemic marker but also a mediator of inflammation.
J. R. Thiele, J. Zeller, H. Bannasch, G. B. Stark, K. Peter, S. U. Eisenhardt   +5 more
doaj   +1 more source

The Clinical Significance and Potential Role of C-Reactive Protein in Chronic Inflammatory and Neurodegenerative Diseases

Frontiers in Immunology, 2018
C-reactive protein (CRP) is an acute-phase protein synthesized by hepatocytes in response to pro-inflammatory cytokines during inflammatory/infectious processes.
Ying-yi Luan, Yong-ming Yao, Yong-ming Yao   +2 more
doaj   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, EarlyView.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

Biomimetic Nanoparticle Delivering Colchicine to Target Endothelial Inflammation for Atherosclerosis Treatment

Advanced NanoBiomed Research, EarlyView.
Platelet membrane‐coated layered double hydroxide nanoparticles were engineered to target inflamed endothelium at early‐stage atherosclerosis and enhance therapeutic efficacy. The biomimetic platform improves stability, immune escape, and inflamed vascular cell targeting, resulting in reduced oxidative stress and downregulated adhesion molecules.
Xiuwen Zhang, Lingqing Zong, Ashish Misra, Sanjay Patel, Zi Gu   +4 more
wiley   +1 more source

Monomeric C-reactive protein in coronary artery disease

Complex Issues of Cardiovascular Diseases, 2020
M. D. Zvereva, O. S. Saburova, I. S. Melnikov, S. G. Kozlov, Z. A. Gabbasov   +4 more
openaire   +2 more sources

Editorial: C-Reactive Protein in Age-Related Disorders, Volume II

Frontiers in Immunology, 2022
Mark Slevin, Mark Slevin, Mark Slevin, Blanca Molins   +3 more
doaj   +1 more source