Results 81 to 90 of about 23,062,194 (220)

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

Advanced Science, EarlyView.
This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka, Marian Bienstein, Jonas Berger, Ulrich Schwaneberg   +3 more
wiley   +1 more source

Structural and functional comparison of native pentameric, denatured monomeric and biotinylated C‐reactive protein

Immunology, 2006
SummaryThere are many controversies surrounding the biological activities of native C‐reactive protein (nCRP) and its various modified forms such as monomerized and biotinylated CRP (mCRP and bCRP). No simple methods have been described to distinguish among these forms. By adapting established electrophoresis methods, we have developed a useful quality
Karolina E, Taylor, Carmen W, van den Berg   +1 more
openaire   +3 more sources

Additional file 1 of Associations of C-reactive protein isoforms with systemic lupus erythematosus phenotypes and disease activity

, 2022
Additional file 1: Supplementary Figure 1. Comparisons of pentameric C-reactive protein (pCRP) (A–D), monomeric (m)CRP (E–H), and mCRP/pCRP ratio (I–L) in 160 patients with systemic lupus erythematosus with lupus nephritis vs.
Jesper Karlsson (12863105), Jonas Wetterö (2432866), Johan Rönnelid (54462), Maria Weiner (12863108), Rafael Fernandez-Botran (3531761), Christopher Sjöwall (3374)   +5 more
core   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Resveratrol Activates Antioxidant Protective Mechanisms in Cellular Models of Alzheimer’s Disease Inflammation

Antioxidants
Resveratrol is a natural phenolic compound with known benefits against neurodegeneration. We analyzed in vitro the protective mechanisms of resveratrol against the proinflammatory monomeric C-reactive protein (mCRP).
Clara Bartra, Yi Yuan, Kristijan Vuraić, Haydeé Valdés-Quiroz, Pau Garcia-Baucells, Mark Slevin, Ylenia Pastorello, Cristina Suñol, Coral Sanfeliu   +8 more
doaj   +1 more source

Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability [PDF]

, 2005
Background - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated.
Stidwill, RP, Singer, M, MacAllister, RJ, Storry, C, Pepys, MB, Vallance, P, Deanfield, JE, Hineorani, AD, Clapp, BR, Hirschfield, GM, Gallimore, JR   +10 more
core  

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

A proteomic analysis of C-reactive protein stimulated THP-1 monocytes [PDF]

, 2011
Background: C-reactive protein (CRP) is a predictor of cardiovascular risk. It circulates as a pentameric protein in plasma. Recently, a potential dissociation mechanism from the disc-shaped pentameric CRP (pCRP) into single monomers (monomeric or mCRP ...
Peter, Karlheinz, Steffen U Eisenhardt, Graeme I Lancaster, Peter, K, Ayhan, M, Karen Oliva, Rice, Greg E., Lancaster, GI, Bannasch, Holger, Ayhan Mustafa, Eisenhardt, Steffen Ulrich, Rice Greg E, Lancaster, Graeme I, Habersberger Jonathon, Rice, Greg E, Eisenhardt Steffen U, Habersberger, Jonathon, Jonathon Habersberger, Karlheinz Peter, Kevin J Woollard, Bannasch, H, Peter Karlheinz, Woollard, KJ, Mustafa Ayhan, Lancaster, Graeme I., Lancaster Graeme I, Oliva, Karen, Eisenhardt, Steffen U., Rice, GE, Oliva Karen, Greg E Rice, Woollard, Kevin J., Woollard Kevin J, Oliva, K, Ayhan, Mustafa, Eisenhardt, SU, Habersberger, J, Bannasch Holger, Holger Bannasch   +38 more
core   +1 more source