Results 61 to 70 of about 21,607,700 (130)

Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction [PDF]

Cardiovascular Research, 2012
Elevated serum C-reactive protein (CRP) following myocardial infarction (MI) is associated with poor outcomes. Although animal studies have indicated a direct pathogenic role of CRP, the mechanism underlying this remains elusive. Dissociation of pentameric CRP (pCRP) into pro-inflammatory monomers (mCRP) may directly link CRP to inflammation.
Habersberger, Jonathon, Strang, Frederik, Scheichl, Amelie, Htun, Nay, Bassler, Nicole, Merivirta, Ruusu-Maaria, Diehl, Philipp, Krippner, Guy, Meikle, Peter, Eisenhardt, Steffen Ulrich, Meredith, Ian, Peter, Karlheinz   +11 more
openaire   +3 more sources

How C-Reactive Protein Structural Isoforms With Distinctive Bioactivities Affect Disease Progression

Frontiers in Immunology, 2020
C-reactive protein (CRP) is a widely known, hepatically synthesized protein whose blood levels change rapidly and pronouncedly in response to any tissue damaging event associated with an inflammatory response.
Ibraheem M. Rajab, Peter C. Hart, Lawrence A. Potempa   +2 more
doaj   +1 more source

Automated design of protein-binding riboswitches for sensing human biomarkers in a cell-free expression system

Nature Communications, 2023
Cell-free genetically encoded biosensors have been developed to detect small molecules and nucleic acids, but they have yet to be reliably engineered to detect proteins.
Grace E. Vezeau, Lipika R. Gadila, Howard M. Salis   +2 more
doaj   +1 more source

Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability [PDF]

, 2005
Background - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated.
Stidwill, RP, Singer, M, MacAllister, RJ, Storry, C, Pepys, MB, Vallance, P, Deanfield, JE, Hineorani, AD, Clapp, BR, Hirschfield, GM, Gallimore, JR   +10 more
core  

Cost-Effectiveness of Point-of-Care C-Reactive Protein Tests for Respiratory Tract Infection in Primary Care in England [PDF]

, 2015
Introduction Despite recommendations that general practitioners (GPs) delay antibiotic prescribing for respiratory tract infections (RTIs), antibiotic prescriptions in primary care in England increased by 4.1% from 2010 to 2013.
Hunter, R, Rachael Hunter
core   +1 more source

Pentameric C-reactive protein is a better prognostic biomarker and remains elevated for longer than monomeric CRP in hospitalized patients with COVID-19

Frontiers in Immunology, 2023
The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome ...
Francis R. Hopkins, Johan Nordgren, Rafael Fernandez-Botran, Helena Enocsson, Melissa Govender, Cecilia Svanberg, Lennart Svensson, Lennart Svensson, Marie Hagbom, Åsa Nilsdotter-Augustinsson, Åsa Nilsdotter-Augustinsson, Sofia Nyström, Sofia Nyström, Christopher Sjöwall, Johanna Sjöwall, Johanna Sjöwall, Marie Larsson   +16 more
doaj   +1 more source

C-Reactive protein and genetic variants and cognitive decline in old age: the PROSPER Study [PDF]

, 2011
Background: Plasma concentrations of C-reactive protein (CRP), a marker of chronic inflammation, have been associated with cognitive impairment in old age. However, it is unknown whether CRP is causally linked to cognitive decline.
van Himbergen Thomas, Rudi G. J. Westendorp, Eliana Polisecki, Trompet, S., Sattar, N., David J. Stott, Ian Ford, Ford Ian, Ford, I., Trompet Stella, Simon P. Mooijaart, David J Stott, Sattar Naveed, Welsh Paul, Himbergen, T. van, Jahn Sabine E., Westendorp Rudi G. J., Jahn, S.E., Paul Welsh, Mooijaart, S.P., Ernst J Schaefer, Schaefer, E.J., Welsh, P., Westendorp, R.G.J., Anton J. M. de Craen, Stott David J., Sabine E. Jahn, Mooijaart Simon P., Craen, A.J.M. de, de Craen, A.J.M., Thomas van Himbergen, Ernst J. Schaefer, Stella Trompet, Polisecki Eliana, Sabine E Jahn, Anton J M de Craen, de Craen Anton J. M., Naveed Sattar, Polisecki, E., van Himbergen, T., null null, Simon P Mooijaart, PROSPER Study Group, PROSPER Study Grp, Stott, D.J., Rudi G J Westendorp, Schaefer Ernst J.   +46 more
core   +2 more sources

Structural and functional comparison of native pentameric, denatured monomeric and biotinylated C‐reactive protein

Immunology, 2006
SummaryThere are many controversies surrounding the biological activities of native C‐reactive protein (nCRP) and its various modified forms such as monomerized and biotinylated CRP (mCRP and bCRP). No simple methods have been described to distinguish among these forms. By adapting established electrophoresis methods, we have developed a useful quality
Karolina E, Taylor, Carmen W, van den Berg   +1 more
openaire   +3 more sources

Resveratrol Activates Antioxidant Protective Mechanisms in Cellular Models of Alzheimer’s Disease Inflammation

Antioxidants
Resveratrol is a natural phenolic compound with known benefits against neurodegeneration. We analyzed in vitro the protective mechanisms of resveratrol against the proinflammatory monomeric C-reactive protein (mCRP).
Clara Bartra, Yi Yuan, Kristijan Vuraić, Haydeé Valdés-Quiroz, Pau Garcia-Baucells, Mark Slevin, Ylenia Pastorello, Cristina Suñol, Coral Sanfeliu   +8 more
doaj   +1 more source

Association of high-sensitive C-reactive protein with advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus [PDF]

, 2006
Background: Type 2 diabetes mellitus is associated with increased cardiovascular risk. One laboratory marker for cardiovascular risk assessment is high-sensitivity C-reactive protein (hsCRP).
Standl, Eberhard, Forst, Thomas, Pahler, Sabine, Schöndorf, Thomas, Pfützner, Andreas, Hohberg, Cloth, Strotmann, Hermann-Josef, Schulze, Jan, Lübben, Georg   +8 more
core   +1 more source