Results 61 to 70 of about 23,062,194 (220)

C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction [PDF]

, 2012
BACKGROUND: There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events.
Iso, Hiroyasu, Kiechl, S. (Stefan), Ridker, P.M., Danesh, J, Ingelsson, E., Fowkes, F. Gerry R., Caslake, M, Ford, I. (Ian), Pennells, L, Folsom, AR, Woodward, M., Thompson, S. G., Barr, E.L., Tybjærg-Hansen, Anne, Walker, M. (Mark), Rodriguez, B. (Beatriz), Kitamura, Akihiko, Lowe, Gordon D O, Howard, BV, Iso, H. (Hiroyasu), Gao, P, Shea, S, Whincup, PH, Jorgensen, T, Deeg, D.J.H. (Dorly), Ford, I, Gillum, R. F., Dekker, Jacqueline M, Walker, M, Cooper, J. A., Davey Smith, George, Barr, EL, Butterworth, Adam S., Woodward, M. (Mark), Lawlor, D.A. (Debbie), Hofman, A., Butterworth, AS, Folsom, A.R. (Aaron), Dekker, JM, Björkelund, C. (Cecilia), Barr, E., Nordestgaard, Børge G., Shea, Steven, Khaw, K-T. (Kay-Tee), White, I. R., Kiyohara, Y., Stehouwer, C.D.A., Packard, Chris J, Pennells, L. (Lisa), Gallacher, John, Tipping, R.W., Sattar, N, Gaziano, JM, Emerging Risk Factors Collaboration, Emerging Risk, Factors, Danesh, J., Bakker, Stephan J. L.; id_orcid, Onat, A., Wood, A., Pepys, M.B. (Mark), Dankner, R, Salomaa, Veikko, D'Agostino, R.B., Thompson, S.G., Salonen, JT, Kuller, L.H. (Lewis), Engström, Gunnar,, Bjorkelund, C., Giampaoli, S. (Simona), Ingelsson, Erik, Ridker, P. M., Benjamin, Emelia J, Salonen, Jukka T, Cremer, P, Gaziano, J.M., Salomaa, V, Rosengren, Annika,, Wood, AM, Ford, Ian, Benjamin, E., Nordestgaard, B.G., Salonen, J.T., Nissinen, A, et al., Fowkes, F Gerry R, Lowe, GDO, Howard, B.V. (Barbara), Dekker, J.M., Cooper, J.A. (Jackie), Dagenais, G. R., D'Agostino, RB, Wennberg, P., Meade, Tom W, Benjamin, EJ, Meade, T. (Tom), Deeg, D., Dekker, J.M. (Jacqueline), Jorgensen, T. (Torben), Butterworth, Adam S, Dankner, R., Lawlor, Debbie A., Deeg, D.J.H., Di Angelantonio, E, Thompson, A. (Alexander), Stehouwer, C.D. (Coen), Wareham, N.J. (Nick), Kiyohara, Yutaka, Bakker, Stephan JL, Folsom, A.R., Gudnason, V. (Vilmundur), Tosetto, Alberto, Wareham, N.J., Dagenais, G.R. (Gilles R), Caslake, M. (Muriel), Tipping, R. W., Davey-Smith, George, Barrett-Connor, Elizabeth, Benjamin, E.J., Kiyohara, Y. (Yutaka), Shaffer, Jonathan A., Meade, T.W., Gao, P., Barrett-Connor, E. (Elizabeth), Thompson, Simon G, Kromhout, D., Tipping, RW, Gaziano, J Michael, Bakker, SJL, D'Agostino, R. B., Brenner, H., Panagiotakos, D. B., Assmann, Gerd, Meade, Tom W., Tipping, Robert W, Shaffer, JA, Brunner, E. (Eric), Brunner, Eric, Barr, E.L.M., Westendorp, R. G., Lund University., Butterworth, A.S., Nissinen, A. (Aulikki), Ridker, PM, Khaw, K. T., Whincup, P.H., Koenig, W, Folsom, Aaron R, Benjamin, E. J., Shea, S., Gudnason, V, Bakker, SJ, Packard, C.J., Koenig, Wolfgang, Strandberg, T. E., Packard, CJ, Pepys, Mark B, Panagiotakos, D.B. (Demosthenes), Bakker, S., Wareham, N. J., Wareham, NJ, Kuller, Lewis H., Rosengren, A, Gaziano, J. M., Assmann, G. (Gerd), Wood, Angela M., Barr, Elizabeth LM, Thompson, Alexander, Gillum, R.F. (Richard), Salomaa, V. (Veikko), Dekker, Jacqueline M., Brenner, H, Psaty, B. M., Deeg, Dory, Panagiotakos, Demosthenes B., Psaty, B.M. (Bruce), Pepys, M. B., Bakker, S.J.L. (Stephan), Rosengren, Annika, Assmann, G, Brunner, E, Kiechl, S, Wareham, Nicholas J., Jorgensen, T., Kromhout, Daan, Kromhout, D, Thompson, A., Dagenais, GR, White, I., Howard, B. V., Fowkes, F.G.R., Hofman, Albert, Giampaoli, S, Wennberg, Patrik, Cooper, Jackie A, Dagenais, Gilles R, Wassertheil-Smoller, S., Wilhelmsen, L, Tosetto, A., Dankner, Rachel, Iso, H, Onat, A, Amouyel, Philippe, Ingelsson, E, Yliopisto, Oulun, Amouyel, P., Kitamura, A, Strandberg, Timo E., Nordestgaard, B. G., White, IR, Di Angelantonio, E., Meade, T. W., Folsom, A. R., Howard, Barbara V., Whincup, Peter H., Kiechl, Stefan, Psaty, Bruce M., Pepys, MB, Dagenais, Gilles R., Khaw, K., Meade, TW, Westendorp, Rudi G, Giampaoli, Simona, Gudnason, V., Stehouwer, CDA, Jørgensen, Torben, Sarwar, S. (Sheryar), Rosengren, A. (Annika), Wilhelmsen, L. (Lars), White, I.R. (Ian), Tosetto, A, Wennberg, P. (Patrik), Brenner, H. (Hermann), Sarwar, Nadeem, Whincup, P.H. (Peter), Salomaa, V., Cooper, Jackie A., Davey-Smith, G. (George), Lowe, G.D.O., Bakker, Stephan J. L., Hofman, Bert, Folsom, Aaron R., Pepys, M.B., Sarwar, N., Deeg, D, White, Ian R, Koenig, W., Fowkes, F. G. R., Shaffer, Jonathan A, Kitamura, A., Caslake, M., Lowe, G.D.O. (Gordon), Psaty, Bruce M, Panagiotakos, DB, Stehouwer, C. D. A., Pepys, Mark B., Whincup, Peter H, Lowe, G. D. O., Di Angelantonio, Emanuele, Sattar, Naveed, Tipping, Robert W., Stehouwer, Coen D. A., Kiyohara, Y, Kuller, L.H., Khaw, KT, Shea, S. (Steven), Wennberg, P, Shaffer, J.A. (Jonathan), Westendorp, R.G., Giampaoli, S., Rosengren, A., Kaptoge, S., Gillum, Richard F, Wareham, Nicholas J, Walker, Matthew, Assman, Gerd, Gallacher, J. (John), Barr, ELM, Wood, Angela M, Ridker, Paul M, Benjamin, E.J. (Emelia), Benjamin, Emelia J., Kaptoge, S, Salonen, Jukka T., Gao, P. (Pei), Bakker, Stephan S. L., Davey-Smith, G., Lawlor, DA, Clarke, Robert, Pennells, Lisa, Kuller, LH, Barr, Elizabeth L M, Pennells, L., Brunner, E., Kiechl, S., Butterworth, A.S. (Adam), D'Agostino, Ralph B, Lawlor, D.A., Rodriguez, B, Clarke, R., Dekker, J. M., Barr, E. L. M., Barr, Elizabeth L. M., Barrett-Connor, E, Koenig, W. (Wolfgang), Lowe, Gordon D. O., Stehouwer, Coen DA, Cremer, Peter, Nissinen, A., Wood, A.M., Nissinen, Aulikki, Cremer, P., Wassertheil-Smoller, S. (Sylvia), Westendorp, R.G.J. (Rudi), Strandberg, T.E., Barrett-Connor, E., Bjorkelund, Cecilia, Gillum, R.F., Clarke, R. (Robert), Nordestgaard, B.G. (Børge), Shaffer, J. A., Engstrom, Gunnar, Gudnason, Vilmundur, Lawlor, D. A., Stehouwer, Coen D A, Packard, C. J., Khaw, Kay-Tee, Wood, A. M., Kuller, L. H., Tosetto, A. (Alberto), Kauhanen, J, D'Agostino, Ralph B., Gaziano, J.M. (J. Michael), Kuller, Lewis H, Sattar, N. (Naveed), Kromhout, D. (Daan), Khaw, K.T., Nordestgaard, BG, Iso, H., Rodriguez, Beatriz, Kaptoge, Stephen, Assmann, G., Clarke, R, Cooper, J.A., Caslake, Muriel, Emerging Risk Factors, Hofman, A. (Albert), Davey-Smith, G, Bakker, S.J.L., Howard, B.V., Bakker, Stephan J L, Sattar, N., Angelantonio, E. (Emanuele) di, D'Agostino, Ralph B., Sr., Lawlor, Debbie A, Gallacher, J., Tipping, A. (Alex), Ford, I., Danesh, John, Kauhanen, J. (Jussi), Björkelund, Cecilia,, Whincup, P. H., Cushman, M., Cushman, M, Strandberg, TE, Butterworth, A. S., Bakker, S. J. L., Ingelsson, E. (Erik), Fowkes, FGR, Rodriguez, B., Cooper, JA, Wassertheil-Smoller, S, Panagiotakos, Demosthenes B, Nordestgaard, Børge G, Panagiotakos, D.B., Kauhanen, J., Nordestgaard, Borge G., Ridker, P.M. (Paul), Kauhanen, Jussi, D'Agostino, R.B. (Ralph), Gillum, RF, Thompson, A, Danesh, J. (John), Stehouwer, Coen D. A.; id_orcid, Danker, Rachel, Sarwar, N, Psaty, BM, Walker, M., Packard, C. (Chris), Onat, A. (Altan), Westendorp, RG, Butterworth, A., White, Ian R., Thompson, S.G. (Simon), Wilhelmsen, L., Woodward, Mark, Dankner, R. (Rachel), Howard, Barbara V, Cushman, Mary, Gillum, Richard F., Strandberg, Timo E, Psaty, B.M., Strandberg, T.E. (Timo), Wood, A.M. (Angela), Amouyel, P. (Philippe), Westendorp, Rudi G., Woodward, M, Lawlor, Debbie H., Lowe, Gordon DO, Salonen, J. T., Onat, Altan, Wilhelmsen, Lars, Gallacher, J, Wassertheil-Smoller, Sylvia, Cushman, M. (Mary Ann), White, I.R., Kaptoge, S. (Stephen), Deeg, Dorly, Brenner, Hermann, Dagenais, G.R., Engstrom, G., Amouyel, P, Gaziano, J. Michael, Shaffer, J.A., Jorgensen, Torben, Thompson, SG, Wennberg, Patrik,, Ridker, Paul M., Packard, Chris J., Fowkes, F.G.R. (F. Gerald R.), Gao, Pei, Thompson, Simon G., Bladbjerg, Else-Marie; id_orcid, Jespersen, Jørgen; id_orcid, Döring, Angela, Nijpels, Giel, Marmot, Michael, Bengtsson, Calle, Haycock, Philip, Eiriksdottir, Gudny, Bauer, Kenneth A., Davidson, Karina W., Hedblad, Bo, Robertson, Michele, Feskens, Edith J. M., Kooperberg, Charles, Meisinger, Christa, Vartiainen, Erkki, Lissner, Lauren, Rapsomaniki, Eleni, Wormser, David, Tilvis, Reijo S., Lee, Amanda J., Buring, Julie, Lubin, Flora, Müller, Heiko, Shipley, Martin, Kivimäki, Mika, Vanuzzo, Diego, Sato, Shinichi, Schulte, Helmut, Astor, Brad C., Lappas, Georgios, Arveiler, Dominique, Fletcher, Astrid, Chrysohoou, Christina, Pencina, Michael J., Kirkland, Susan, Atkins, Robert, Bettencourt, Richele, Després, Jean-Pierre, Dehghan, Abbas, Buckley, Brendan M., Shaw, Jonathan E., Thorsson, Bolli, Nagel, Dorothea, Bremmer, Marijke A., Jansson, Jan-Håkan, Harald, Kennet, Tunstall-Pedoe, Hugh, Doi, Yasufumi, Vasan, Ramachandran S., Kardys, Isabella, Cobbe, Stuart M., Frikke-Schmidt, Ruth, Zhao, Xiaohui, Collins, Rory, Donfrancesco, Chiara, Stampfer, Meir, Willeit, Johann, Shepherd, James, Chambless, Lloyd E., Ballantyne, Christie M., Welin, Lennart, Mussolino, Michael, Ebrahim, Shah, Fowkes, F Gerry R., Rothenbacher, Dietrich, Witteman, Jacqueline, Møller, Lars, Svärdsudd, Kurt, Sigurdsson, Gunnar, Benn, Marianne, Panico, Salvatore, Ferrières, Jean, Cederholm, Tommy, Tracy, Russ, Nilsson, Peter, Franco, Oscar H., Kaplan, Robert, Zimmet, Paul Z., Cook, Nancy, Arima, Hisatomi, Gansevoort, Ron T., Wolf, Philip A., Wingard, Deborah L., Pilotto, Lorenza, Knottenbelt, Christine, Alexander, Myriam, Watson, Sarah, Pitsavos, Christos, Shimbo, Daichi, Can, GÜNAY, Gobin, Reeta, Eriksson, Henry, Yamagishi, Kazumasa, Lewington, Sarah, Bladbjerg, Else-Marie, Byberg, Liisa, Umans, Jason, Schöttker, Ben, Cantin, Bernard, Chetrit, Angela, Goya Wannamethee, S., Jousilahti, Pekka, Seshasai, Sreenivasa R Kondapally, Hillege, Hans L., Morris, Richard W., Mayr, Agnes, Palmieri, Luigi, Best, Lyle, Ben-Shlomo, Yoav, Grandits, Greg, Tavendale, Roger, Basu, Samar, Ninomiya, Toshiharu, Jespersen, Jørgen, Yarnell, John W., Schett, Georg, Stefanadis, Christodoulos, Noda, Hiroyuki, Michael Gaziano, J., Aspelund, Thor, Lamarche, Benoît, Zhang, Ying, Evans, Alun, Rodeghiero, Francesco, Angelantonio, E. di, Engstrom, G, Bjorkelund, C   +558 more
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Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?

Frontiers in Immunology, 2023
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Anne Helene Køstner, Anne Helene Køstner, Anniken Jørlo Fuglestad, Anniken Jørlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten, Christian Kersten   +14 more
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Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction [PDF]

Cardiovascular Research, 2012
Elevated serum C-reactive protein (CRP) following myocardial infarction (MI) is associated with poor outcomes. Although animal studies have indicated a direct pathogenic role of CRP, the mechanism underlying this remains elusive. Dissociation of pentameric CRP (pCRP) into pro-inflammatory monomers (mCRP) may directly link CRP to inflammation.
Habersberger, Jonathon, Strang, Frederik, Scheichl, Amelie, Htun, Nay, Bassler, Nicole, Merivirta, Ruusu-Maaria, Diehl, Philipp, Krippner, Guy, Meikle, Peter, Eisenhardt, Steffen Ulrich, Meredith, Ian, Peter, Karlheinz   +11 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
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Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
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How C-Reactive Protein Structural Isoforms With Distinctive Bioactivities Affect Disease Progression

Frontiers in Immunology, 2020
C-reactive protein (CRP) is a widely known, hepatically synthesized protein whose blood levels change rapidly and pronouncedly in response to any tissue damaging event associated with an inflammatory response.
Ibraheem M. Rajab, Peter C. Hart, Lawrence A. Potempa   +2 more
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Automated design of protein-binding riboswitches for sensing human biomarkers in a cell-free expression system

Nature Communications, 2023
Cell-free genetically encoded biosensors have been developed to detect small molecules and nucleic acids, but they have yet to be reliably engineered to detect proteins.
Grace E. Vezeau, Lipika R. Gadila, Howard M. Salis   +2 more
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The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
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Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

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Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
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