Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline [PDF]
, 2016 Acknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the
Cranston, Anna +5 more
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C-Reactive Protein in Atherothrombosis and Angiogenesis
Frontiers in Immunology, 2018 C-reactive protein (CRP) is a short pentraxin mainly found as a pentamer in the circulation, or as non-soluble monomers CRP (mCRP) in tissues, exerting different functions.
Lina Badimon +10 more
doaj +1 more source
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease [PDF]
, 2015 Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown.
Andrey Y. Abramov +16 more
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Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells [PDF]
Basic Research in Cardiology, 2011 C-reactive protein (CRP) has been linked to the pathogenesis of atherosclerosis. The dissociation of native, pentameric (p)CRP to monomeric (m)CRP on the cell membrane of activated platelets has recently been demonstrated. The dissociation of pCRP to mCRP may explain local pro-inflammatory reactions at the site of developing atherosclerotic plaques. As
Ahrens, I +11 more
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C-reactive protein isoforms as prognostic markers of COVID-19 severity
Frontiers in Immunology, 2023 C-reactive protein (CRP), an active regulator of the innate immune system, has been related to COVID-19 severity. CRP is a dynamic protein undergoing conformational changes upon activation in inflammatory microenvironments between pentameric and ...
Blanca Molins +12 more
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The Effect of C-Reactive Protein Isoforms on Nitric Oxide Production by U937 Monocytes/Macrophages
Frontiers in Immunology, 2018 Inflammation is regulated by many endogenous factors including estrogen, a steroid hormone that declines with increasing age, leading to excessive inflammation in the elderly. C-reactive protein (CRP) is an acute phase inflammatory protein that exists in
Nicola R. Sproston +4 more
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An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behavior [PDF]
, 2016 Serpins are important regulators of proteolytic pathways with an antiprotease activity that involves a conformational transition from a metastable to a hyperstable state. Certain mutations permit the transition to occur in the absence of a protease; when
Faull, Sarah V. +14 more
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Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]
, 2015 Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Abramov, AY +5 more
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REACTIVITY OF CHLOROPHYLL a/b-PROTEINS AND MICELLAR TRITON X-100 COMPLEXES OF CHLOROPHYLLS a OR b WITH BOROHYDRIDE [PDF]
, 1989 The reaction of several plant chlorophyll-protein complexes with NaBH4 has been studied by absorption spectroscopy. In all the complexes studied, chlorophyll b is more reactive than Chi a, due to preferential reaction of its formyl substituent at C-7 ...
Arnon D. I. +15 more
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C-reactive protein (CRP) aptamer binds to monomeric but not pentameric form of CRP [PDF]
Analytical and Bioanalytical Chemistry, 2011 Native C-reactive protein (CRP) is composed of five identical subunits arranged in a pentameric structure (pCRP). Binding of pCRP to damaged cell membranes produces a second isoform, modified CRP, which has similar antigenicity to isolated monomeric subunits of CRP (mCRP).
Min S, Wang +3 more
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