Results 41 to 50 of about 41,733 (199)

C-Reactive Protein in Atherothrombosis and Angiogenesis

Frontiers in Immunology, 2018
C-reactive protein (CRP) is a short pentraxin mainly found as a pentamer in the circulation, or as non-soluble monomers CRP (mCRP) in tissues, exerting different functions.
Lina Badimon, Lina Badimon, Esther Peña, Esther Peña, Gemma Arderiu, Teresa Padró, Teresa Padró, Mark Slevin, Gemma Vilahur, Gemma Vilahur, Gemma Chiva-Blanch   +10 more
doaj   +1 more source

Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells [PDF]

Basic Research in Cardiology, 2011
C-reactive protein (CRP) has been linked to the pathogenesis of atherosclerosis. The dissociation of native, pentameric (p)CRP to monomeric (m)CRP on the cell membrane of activated platelets has recently been demonstrated. The dissociation of pCRP to mCRP may explain local pro-inflammatory reactions at the site of developing atherosclerotic plaques. As
Ahrens, I, Domeij, H, Eisenhardt, SU, Topcic, D, Albrecht, M, Leitner, E, Viitaniemi, K, Jowett, JB, Lappas, M, Bode, C, Haviv, I, Peter, K   +11 more
openaire   +3 more sources

C-reactive protein isoforms as prognostic markers of COVID-19 severity

Frontiers in Immunology, 2023
C-reactive protein (CRP), an active regulator of the innate immune system, has been related to COVID-19 severity. CRP is a dynamic protein undergoing conformational changes upon activation in inflammatory microenvironments between pentameric and ...
Blanca Molins, Marc Figueras-Roca, Marc Figueras-Roca, Oliver Valero, Víctor Llorenç, Víctor Llorenç, Sara Romero-Vázquez, Oriol Sibila, Alfredo Adán, Alfredo Adán, Carolina García-Vidal, Alex Soriano, Alex Soriano   +12 more
doaj   +1 more source

C-reactive protein (CRP) aptamer binds to monomeric but not pentameric form of CRP [PDF]

Analytical and Bioanalytical Chemistry, 2011
Native C-reactive protein (CRP) is composed of five identical subunits arranged in a pentameric structure (pCRP). Binding of pCRP to damaged cell membranes produces a second isoform, modified CRP, which has similar antigenicity to isolated monomeric subunits of CRP (mCRP).
Min S, Wang, Joshua C, Black, Michelle K, Knowles, Scott M, Reed   +3 more
openaire   +2 more sources

The Effect of C-Reactive Protein Isoforms on Nitric Oxide Production by U937 Monocytes/Macrophages

Frontiers in Immunology, 2018
Inflammation is regulated by many endogenous factors including estrogen, a steroid hormone that declines with increasing age, leading to excessive inflammation in the elderly. C-reactive protein (CRP) is an acute phase inflammatory protein that exists in
Nicola R. Sproston, Mohamed El Mohtadi, Mark Slevin, William Gilmore, Jason J. Ashworth   +4 more
doaj   +1 more source

CRP Enhances the Innate Killing Mechanisms Phagocytosis and ROS Formation in a Conformation and Complement-Dependent Manner

Frontiers in Immunology, 2021
Phagocytosis and the formation of reactive oxygen species (ROS) in phagocytic leukocytes are an effective killing mechanism of the innate host defense. These cellular processes of innate immunity function in a complex interplay with humoral factors.
Johannes Zeller, Balázs Bogner, Jurij Kiefer, David Braig, David Braig, Oscar Winninger, Mark Fricke, Ebru Karasu, Karlheinz Peter, Karlheinz Peter, Markus Huber-Lang, Steffen Ulrich Eisenhardt   +11 more
doaj   +1 more source

Serum CRP interacts with SPARC and regulate immune response in severe cases of COVID-19 infection

Frontiers in Immunology, 2023
Serum C-reactive protein (CRP) has been found elevated during COVID-19 infection, and associated with systematic inflammation as well as a poor clinical outcome.
Chengyang Liu, Chenyang Zheng, Xipeng Shen, Ling Liang, Qiuyu Li   +4 more
doaj   +1 more source

C-reactive protein: a target for therapy to reduce inflammation

Frontiers in Immunology, 2023
C-reactive protein (CRP) is well-recognized as a sensitive biomarker of inflammation. Association of elevations in plasma/serum CRP level with disease state has received considerable attention, even though CRP is not a specific indicator of a single ...
Salma A. Rizo-Téllez, Salma A. Rizo-Téllez, Meriem Sekheri, Meriem Sekheri, János G. Filep, János G. Filep   +5 more
doaj   +1 more source

CRP Is Transported by Monocytes and Monocyte-Derived Exosomes in the Blood of Patients with Coronary Artery Disease

Biomedicines, 2020
The objective of this work was to study the ability of blood cells and their microparticles to transport monomeric and pentameric forms of C-reactive protein (mCRP and pCRP) in the blood of patients with coronary artery disease (CAD).
Ivan Melnikov, Sergey Kozlov, Olga Saburova, Ekaterina Zubkova, Olga Guseva, Sergey Domogatsky, Tatiana Arefieva, Natalia Radyukhina, Maria Zvereva, Yuliya Avtaeva, Lyudmila Buryachkovskaya, Zufar Gabbasov   +11 more
doaj   +1 more source

Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction [PDF]

Cardiovascular Research, 2012
Elevated serum C-reactive protein (CRP) following myocardial infarction (MI) is associated with poor outcomes. Although animal studies have indicated a direct pathogenic role of CRP, the mechanism underlying this remains elusive. Dissociation of pentameric CRP (pCRP) into pro-inflammatory monomers (mCRP) may directly link CRP to inflammation.
Habersberger, Jonathon, Strang, Frederik, Scheichl, Amelie, Htun, Nay, Bassler, Nicole, Merivirta, Ruusu-Maaria, Diehl, Philipp, Krippner, Guy, Meikle, Peter, Eisenhardt, Steffen Ulrich, Meredith, Ian, Peter, Karlheinz   +11 more
openaire   +3 more sources