Results 41 to 50 of about 23,062,194 (220)

C-Reactive Protein and Cancer—Diagnostic and Therapeutic Insights

Frontiers in Immunology, 2020
Cancer disease describes any pathology involving uncontrolled cell growth. As cells duplicate, they can remain localized in defined tissues, forming tumor masses and altering their microenvironmental niche, or they can disseminate throughout the body in ...
Peter C. Hart, Ibraheem M. Rajab, May Alebraheem, Lawrence A. Potempa   +3 more
doaj   +1 more source

Role of C-Reactive Protein at Sites of Inflammation and Infection

Frontiers in Immunology, 2018
C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. CRP is produced as a homopentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of ...
Nicola R. Sproston, Jason J. Ashworth
doaj   +1 more source

Different effects of oral and transdermal hormone replacement therapies on Factor IX, APC resistance, t-PA, PAI and C- reactive protein - a cross-sectional population survey [PDF]

, 2001
The effects of hormone replacement therapy (HRT) on thrombosis risk, thrombotic variables, and the inflammatory marker C- reactive protein (CRP) may vary by route of administration (oral versus transdermal).
Lowe, G.D.O., Rumley, A., McConnachie, A., Upton, M.N., Watt, G.C.M., O'Reilly, D.S.   +5 more
core   +6 more sources

C-Reactive Protein in Atherothrombosis and Angiogenesis

Frontiers in Immunology, 2018
C-reactive protein (CRP) is a short pentraxin mainly found as a pentamer in the circulation, or as non-soluble monomers CRP (mCRP) in tissues, exerting different functions.
Lina Badimon, Lina Badimon, Esther Peña, Esther Peña, Gemma Arderiu, Teresa Padró, Teresa Padró, Mark Slevin, Gemma Vilahur, Gemma Vilahur, Gemma Chiva-Blanch   +10 more
doaj   +1 more source

C-reactive protein (CRP) aptamer binds to monomeric but not pentameric form of CRP [PDF]

Analytical and Bioanalytical Chemistry, 2011
Native C-reactive protein (CRP) is composed of five identical subunits arranged in a pentameric structure (pCRP). Binding of pCRP to damaged cell membranes produces a second isoform, modified CRP, which has similar antigenicity to isolated monomeric subunits of CRP (mCRP).
Min S, Wang, Joshua C, Black, Michelle K, Knowles, Scott M, Reed   +3 more
openaire   +2 more sources

C-reactive protein is essential for innate resistance to pneumococcal infection. [PDF]

, 2014
No deficiency of human C-reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not known.
Lawrence, Rachel A., Read, Kevin D., Aviva Petrie, Pepys, M B, Pepys, MB, Hutchinson, Winston L., Read, Kevin D, Raynes, JG, Read, KD, J. Brian Souza, Tennent, G A, Stephan Ellmerich, Loeffler, JM, Simons, JP, Rachel A. Lawrence, Simons, J Paul, Tennent, GA, John G. Raynes, Glenys A. Tennent, Ellmerich, Stephan, Ellmerich, S, Tennent, Glenys A, Al-Shawi, Raya, Petrie, A, Tennent, Glenys A., Simons, J. Paul, Lawrence, R A, Jutta M. Loeffler, Lawrence, RA, Hutchinson, Winston L, J. Paul Simons, de Souza, J Brian, de Souza, J. Brian, Kevin D. Read, Raynes, John G., Raynes, J G, Read, K D, Mark B. Pepys, Hutchinson, WL, de Souza, JB, Loeffler, Jutta M, Petrie, Aviva, Al-Shawi, R, Pepys, Mark B., Lawrence, Rachel A, Raynes, John G, Loeffler, J M, de Souza, J B, Hutchinson, W L, Pepys, Mark B, Raya Al‐Shawi, Winston L. Hutchinson, Loeffler, Jutta M., Simons, J P   +53 more
core   +1 more source

C-reactive protein isoforms as prognostic markers of COVID-19 severity

Frontiers in Immunology, 2023
C-reactive protein (CRP), an active regulator of the innate immune system, has been related to COVID-19 severity. CRP is a dynamic protein undergoing conformational changes upon activation in inflammatory microenvironments between pentameric and ...
Blanca Molins, Marc Figueras-Roca, Marc Figueras-Roca, Oliver Valero, Víctor Llorenç, Víctor Llorenç, Sara Romero-Vázquez, Oriol Sibila, Alfredo Adán, Alfredo Adán, Carolina García-Vidal, Alex Soriano, Alex Soriano   +12 more
doaj   +1 more source

The Effect of C-Reactive Protein Isoforms on Nitric Oxide Production by U937 Monocytes/Macrophages

Frontiers in Immunology, 2018
Inflammation is regulated by many endogenous factors including estrogen, a steroid hormone that declines with increasing age, leading to excessive inflammation in the elderly. C-reactive protein (CRP) is an acute phase inflammatory protein that exists in
Nicola R. Sproston, Mohamed El Mohtadi, Mark Slevin, William Gilmore, Jason J. Ashworth   +4 more
doaj   +1 more source

Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells [PDF]

Basic Research in Cardiology, 2011
C-reactive protein (CRP) has been linked to the pathogenesis of atherosclerosis. The dissociation of native, pentameric (p)CRP to monomeric (m)CRP on the cell membrane of activated platelets has recently been demonstrated. The dissociation of pCRP to mCRP may explain local pro-inflammatory reactions at the site of developing atherosclerotic plaques. As
Ahrens, I, Domeij, H, Eisenhardt, SU, Topcic, D, Albrecht, M, Leitner, E, Viitaniemi, K, Jowett, JB, Lappas, M, Bode, C, Haviv, I, Peter, K   +11 more
openaire   +3 more sources

CRP Enhances the Innate Killing Mechanisms Phagocytosis and ROS Formation in a Conformation and Complement-Dependent Manner

Frontiers in Immunology, 2021
Phagocytosis and the formation of reactive oxygen species (ROS) in phagocytic leukocytes are an effective killing mechanism of the innate host defense. These cellular processes of innate immunity function in a complex interplay with humoral factors.
Johannes Zeller, Balázs Bogner, Jurij Kiefer, David Braig, David Braig, Oscar Winninger, Mark Fricke, Ebru Karasu, Karlheinz Peter, Karlheinz Peter, Markus Huber-Lang, Steffen Ulrich Eisenhardt   +11 more
doaj   +1 more source