C-Reactive Protein (CRP) and Leptin Receptor in Obesity: Binding of Monomeric CRP to Leptin Receptor [PDF]
Frontiers in Immunology, 2018 While leptin deficiency or dysfunction leads to morbid obesity, obese subjects are characterized paradoxically by hyperleptinemia indicating lack of response to leptin.
Manu Sudhakar +4 more
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Topological localization of monomeric C-reactive protein determines proinflammatory endothelial cell responses. [PDF]
J Biol Chem, 2014 The activation of endothelial cells (ECs) by monomeric C-reactive protein (mCRP) has been implicated in contributing to atherogenesis. However, the potent proinflammatory actions of mCRP on ECs in vitro appear to be incompatible with the atheroprotective effects of mCRP in a mouse model.
Li HY +8 more
europepmc +4 more sources
Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants. [PDF]
Sci Rep, 2016 Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) have been shown to be associated with an increased risk for AMD, the ...
Molins B +6 more
europepmc +2 more sources
The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action. [PDF]
PLoS ONE, 2014 The prototypic acute phase reactant C-reactive protein (CRP) is not only a marker but also a potential contributor to inflammatory diseases. CRP exists as the circulating native, pentameric CRP (pCRP) and the monomeric isoform (mCRP), formed as a result ...
Masaaki Fujita +3 more
doaj +2 more sources
Frontiers in Immunology, 2023 The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome ...
Francis R. Hopkins +16 more
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Corrigendum: The cholesterol-binding sequence in monomeric C-reactive protein binds to the SARS-CoV-2 spike receptor-binding domain and blocks interaction with Angiotensin-converting enzyme 2 [PDF]
Frontiers in Immunology, 2022 Hai-yun Li +9 more
doaj +2 more sources
Corrigendum: Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation [PDF]
Frontiers in Immunology, 2020 Zhe-Kun Jia +6 more
doaj +2 more sources
Microglial pro-inflammatory mechanisms induced by monomeric C-reactive protein are counteracted by soluble epoxide hydrolase inhibitors [PDF]
International ImmunopharmacologySandra Codony
exaly +2 more sources
C-Reactive Protein and Cancer—Diagnostic and Therapeutic Insights
Frontiers in Immunology, 2020 Cancer disease describes any pathology involving uncontrolled cell growth. As cells duplicate, they can remain localized in defined tissues, forming tumor masses and altering their microenvironmental niche, or they can disseminate throughout the body in ...
Peter C. Hart +3 more
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Role of C-Reactive Protein at Sites of Inflammation and Infection
Frontiers in Immunology, 2018 C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. CRP is produced as a homopentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of ...
Nicola R. Sproston, Jason J. Ashworth
doaj +1 more source