Corrigendum: The cholesterol-binding sequence in monomeric C-reactive protein binds to the SARS-CoV-2 spike receptor-binding domain and blocks interaction with Angiotensin-converting enzyme 2 [PDF]
Frontiers in Immunology, 2022 Hai-yun Li +9 more
doaj +2 more sources
Corrigendum: Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation [PDF]
Frontiers in Immunology, 2020 Zhe-Kun Jia +6 more
doaj +2 more sources
Monomeric C-Reactive Protein - A Feature of Inflammatory Disease Associated With Cardiovascular Pathophysiological Complications? [PDF]
In Vivo, 2021 Monomeric C-reactive protein (mCRP), the dissociated form of native C-reactive protein, is a critical molecule that causes and perpetuates inflammation in serious diseases. It has 'adhesive'-like properties causing aggregation of blood cells and platelets, and can stick permanently within arterial tissue where it can contribute to further complications
Zeinolabediny Y, Kumar S, Slevin M.
europepmc +4 more sources
Monomeric C-reactive protein and inflammatory injury in myocardial infarction. [PDF]
Cardiovasc Res, 2012 This editorial refers to ‘Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction’ by J. Habersberger et al. , pp. 64–72, this issue. C-reactive protein, a member of the pentraxin superfamily, is a prototypical ‘acute-phase’ protein that is synthesized at a low rate under physiological ...
Frangogiannis NG.
europepmc +4 more sources
Monomeric C-reactive protein and inflammation in age-related macular degeneration. [PDF]
J Pathol, 2016 AbstractAge‐related macular degeneration (AMD) is a devastating disease characterized by central vision loss in elderly individuals. Previous studies have suggested a link between elevated levels of total C‐reactive protein (CRP) in the choroid, CFH genotype, and AMD status; however, the structural form of CRP present in the choroid, its relationship ...
Chirco KR +7 more
europepmc +4 more sources
An Intrinsically Disordered Motif Mediates Diverse Actions of Monomeric C-reactive Protein. [PDF]
J Biol Chem, 2016 Most proinflammatory actions of C-reactive protein (CRP) are only expressed following dissociation of its native pentameric assembly into monomeric form (mCRP). However, little is known about what underlies the greatly enhanced activities of mCRP. Here we show that a single sequence motif, i.e. cholesterol binding sequence (CBS; a.a.
Li HY +11 more
europepmc +4 more sources
C-Reactive Protein and Cancer—Diagnostic and Therapeutic Insights
Frontiers in Immunology, 2020 Cancer disease describes any pathology involving uncontrolled cell growth. As cells duplicate, they can remain localized in defined tissues, forming tumor masses and altering their microenvironmental niche, or they can disseminate throughout the body in ...
Peter C. Hart +3 more
doaj +1 more source
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease [PDF]
, 2015 Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown.
Andrey Y. Abramov +16 more
core +5 more sources
C-Reactive Protein in Atherothrombosis and Angiogenesis
Frontiers in Immunology, 2018 C-reactive protein (CRP) is a short pentraxin mainly found as a pentamer in the circulation, or as non-soluble monomers CRP (mCRP) in tissues, exerting different functions.
Lina Badimon +10 more
doaj +1 more source
Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline [PDF]
, 2016 Acknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the
Cranston, Anna +5 more
core +3 more sources