High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome [PDF]
Journal of Medical Biochemistry, 2018 PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly ...
Kraszewska-Glomba Barbara +3 more
doaj +5 more sources
Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms. [PDF]
PLoS ONE, 2019 C-reactive proteins (CRPs) are among the faster acute-phase inflammation-responses proteins encoded by one gene (hcrp) in humans and seven genes (crp1-7) in zebrafish (Danio rerio) with importance in bacterial and viral infections.
Melissa Bello-Perez +4 more
doaj +6 more sources
Monomeric C-reactive protein: a link between chronic inflammation and neurodegeneration? [PDF]
Neural Regeneration Research, 2023 Nicoleta Arnaut +2 more
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Monomeric C-Reactive Protein in Atherosclerotic Cardiovascular Disease: Advances and Perspectives. [PDF]
Int J Mol Sci, 2023 This review aimed to trace the inflammatory pathway from the NLRP3 inflammasome to monomeric C-reactive protein (mCRP) in atherosclerotic cardiovascular disease. CRP is the final product of the interleukin (IL)-1β/IL-6/CRP axis. Its monomeric form can be produced at sites of local inflammation through the dissociation of pentameric CRP and, to some ...
Melnikov I +5 more
europepmc +5 more sources
Monomeric C-reactive protein as a therapeutic target in inflammatory diseases [PDF]
RMD OpenChitose Fujita +3 more
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Monomeric C-reactive protein: A novel biomarker predicting neurodegenerative disease and vascular dysfunction. [PDF]
Brain Pathol, 2023 AbstractCirculating C‐reactive protein (pCRP) concentrations rise dramatically during both acute (e.g., following stroke) or chronic infection and disease (e.g., autoimmune conditions such as lupus), providing complement fixation through C1q protein binding. It is now known, that on exposure to the membranes of activated immune cells (and microvesicles
Pastorello Y +5 more
europepmc +6 more sources
The Cholesterol-Binding Sequence in Monomeric C-Reactive Protein Binds to the SARS-CoV-2 Spike Receptor-Binding Domain and Blocks Interaction With Angiotensin-Converting Enzyme 2 [PDF]
Frontiers in Immunology, 2022 The receptor-binding domain (RBD) of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the human angiotensin-converting enzyme 2 (ACE2) receptor, which is a prerequisite for the virus to enter the cell. C-reactive
Hai-yun Li +9 more
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The monomeric C-reactive protein level is associated with the increase in carotid plaque number in patients with subclinical carotid atherosclerosis [PDF]
Frontiers in Cardiovascular Medicine, 2022 The high-sensitivity C-reactive protein (hsCRP) assay measures the level of the pentameric form of CRP in blood. Currently, there are no available assays measuring the level of the monomeric form of CRP (mCRP), produced at sites of local inflammation. We
Ivan Melnikov +15 more
doaj +2 more sources
Role of C-Reactive Protein at Sites of Inflammation and Infection
Frontiers in Immunology, 2018 C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. CRP is produced as a homopentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of ...
Nicola R. Sproston, Jason J. Ashworth
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Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow [PDF]
Cardiovascular Research, 2011 We previously reported that C-reactive protein bioactivity on thrombogenesis was based on loss of its pentameric symmetry, resulting in formation of monomeric C-reactive protein. Our purpose was to provide mechanistic information on the direct effects of C-reactive protein isoforms on platelet activation and provide a C-reactive protein dissociation ...
Molins, B +3 more
openaire +5 more sources