Results 1 to 10 of about 163,143 (174)

Monomeric CRP regulates inflammatory responses in human intervertebral disc cells [PDF]

Bone and Joint Research, 2023
Aims: CRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined.
Clara Ruiz-Fernández, Maria Gonzalez-Rodriguez, Alfonso Cordero-Barreal   +2 more
exaly   +7 more sources

C-Reactive Protein (CRP) and Leptin Receptor in Obesity: Binding of Monomeric CRP to Leptin Receptor [PDF]

Frontiers in Immunology, 2018
While leptin deficiency or dysfunction leads to morbid obesity, obese subjects are characterized paradoxically by hyperleptinemia indicating lack of response to leptin.
Manu Sudhakar, Santhi Silambanan, Abhinand S. Chandran, Athira A. Prabhakaran, Ramya Ramakrishnan   +4 more
doaj   +6 more sources

Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons [PDF]

Journal of Inflammation Research, 2021
Revathy Munuswamy,1,* Jana De Brandt,2,* Chris Burtin,2 Wim Derave,3 Joseph Aumann,4 Martijn A Spruit,5,6,* Luc Michiels1,* 1Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium;
Munuswamy R, De Brandt J, Burtin C, Derave W, Aumann J, Spruit MA, Michiels L   +6 more
doaj   +9 more sources

Monomeric CRP Aggravates Myocardial Injury After Myocardial Infarction by Polarizing the Macrophage to Pro-Inflammatory Phenotype Through JNK Signaling Pathway [PDF]

Journal of Inflammation Research, 2021
Zhimin Zha,1,* Yujia Cheng,2,3,* Lu Cao,2 Yanxia Qian,2 Xinjian Liu,3,4 Yan Guo,1 Junhong Wang2 1Department of Gerontology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of ...
Zha Z, Cheng Y, Cao L, Qian Y, Liu X, Guo Y, Wang J   +6 more
doaj   +5 more sources

Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?

Frontiers in Immunology, 2023
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Torben Steiniche, Christian Kersten, Patricia S. Nielsen   +2 more
exaly   +3 more sources

Monomeric CRP is prevalent in the blood of patients with rheumatoid arthritis and correlates with clinically relevant markers [PDF]

Frontiers in Immunology
IntroductionElevated C-reactive protein (CRP) is a hallmark of rheumatoid arthritis (RA) flares. CRP exists as pentameric (pCRP) and monomeric (mCRP) isoforms with distinct functions, with pCRP generally pro-inflammatory and mCRP more immunomodulatory ...
Alexia Correia Ferreira, Lucia Martin-Gutierrez, Christophe Lalaurie, Karen Feehan, Priyanka Lakhani, Imogen Buckle, George A. Robinson, Elizabeth C. Jury, Jessica J. Manson, Jessica J. Manson, Thomas C. R. McDonnell   +10 more
doaj   +2 more sources

C-reactive protein in cardiovascular disease: clinical associations, conformation-dependent biology, and therapeutic perspectives [PDF]

Frontiers in Immunology
C-reactive protein (CRP) is a widely used biomarker of systemic inflammation and cardiovascular risk. Its clinical and experimental relevance has been investigated across major cardiovascular disease (CVD) phenotypes, including coronary artery disease ...
Bingxing Gong, Haiqin Xu, Honglan Liu, Mengmeng Wang, Kailin Yang, Junpeng Chen, Xiaoyang Guo, Tianqing Zhang, Liangqing Ge   +8 more
doaj   +2 more sources

C-reactive protein: the nexus between inflammation and protein misfolding diseases [PDF]

Frontiers in Immunology
C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Abhishek Roy, Abhishek Roy, Johannes Zeller, Johannes Zeller, Tracy L. Nero, Tracy L. Nero, Tracy L. Nero, Johanna Klepetko, Steffen U. Eisenhardt, Michael W. Parker, Michael W. Parker, Michael W. Parker, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter   +19 more
doaj   +2 more sources

High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome [PDF]

Journal of Medical Biochemistry, 2018
PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly ...
Leszek Szenborn, Magdalena Krajewska, Marta Myszka-Kozłowska   +2 more
exaly   +1 more source

Circulating Levels of the Proinflammatory Monomeric Isoform of C-Reactive Protein (mCRP) Correlate with Intra-Tumoral mCRP Abundance in Stage II-III Colon Cancer Patients [PDF]

Journal of Inflammation Research
Anniken Jørlo Fuglestad,1– 3 Paula Anna Bousquet,1 Anne Helene Køstner,3 Sebastian Meltzer,1 Britta Kleist,4 Anne Hansen Ree,1,2 Ibraheem M Rajab,5 Lawrence A Potempa,6 Rafael Fernandez-Botran,7 Christian Kersten1,3 1Department of Oncology, Akershus ...
Fuglestad AJ, Bousquet PA, Køstner AH, Meltzer S, Kleist B, Ree AH, Rajab IM, Potempa LA, Fernandez-Botran R, Kersten C   +9 more
doaj   +2 more sources