Results 21 to 30 of about 272,971 (193)

CRP Enhances the Innate Killing Mechanisms Phagocytosis and ROS Formation in a Conformation and Complement-Dependent Manner

Frontiers in Immunology, 2021
Phagocytosis and the formation of reactive oxygen species (ROS) in phagocytic leukocytes are an effective killing mechanism of the innate host defense. These cellular processes of innate immunity function in a complex interplay with humoral factors.
Johannes Zeller, Balázs Bogner, Jurij Kiefer, David Braig, David Braig, Oscar Winninger, Mark Fricke, Ebru Karasu, Karlheinz Peter, Karlheinz Peter, Markus Huber-Lang, Steffen Ulrich Eisenhardt   +11 more
doaj   +2 more sources

Serum CRP interacts with SPARC and regulate immune response in severe cases of COVID-19 infection

Frontiers in Immunology, 2023
Serum C-reactive protein (CRP) has been found elevated during COVID-19 infection, and associated with systematic inflammation as well as a poor clinical outcome.
Chengyang Liu, Chenyang Zheng, Xipeng Shen, Ling Liang, Qiuyu Li   +4 more
doaj   +2 more sources

From Homeostasis To Inflammation To Autoimmunity: The Potential Impact of CRP. [PDF]

Inflammation
C-reactive protein (CRP) is a highly conserved pentraxin, synthesized primarily in the liver, and is widely recognized as a highly sensitive biomarker for inflammation and tissue damage.
Ahmed M, Yuan P, Lei JG, Tang ZM, Yang ZR, Potempa LA, Wang HY, Li HY.   +7 more
europepmc   +2 more sources

Monomeric C‐reactive protein induces the cellular pathology of Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction Human study shows that elevated C‐reactive protein (CRP) in blood impacts apolipoprotein E (APOE) ε4, but not APOE ε3 or APOE ε2, genotype to increase the risk of Alzheimer's disease (AD).
Qini Gan, Alfred Wong, Zhengrong Zhang, Hana Na, Hua Tian, Qiushan Tao, Ibraheem M. Rajab, Lawrence A. Potempa, Wei Qiao Qiu   +8 more
doaj   +2 more sources

Monomeric C-reactive protein as a biomarker for major depressive disorder

Frontiers in Psychiatry
Neuroinflammation has been postulated to be a key factor in the pathogenesis of major depressive disorder (MDD). With this is mind, there has been a wave of research looking into pro-inflammatory mediators as potential biomarkers for MDD.
Mary G. Hornick, Lawrence A. Potempa
doaj   +2 more sources

Monomeric C-Reactive Protein in Atherosclerotic Cardiovascular Disease: Advances and Perspectives

International Journal of Molecular Sciences, 2023
This review aimed to trace the inflammatory pathway from the NLRP3 inflammasome to monomeric C-reactive protein (mCRP) in atherosclerotic cardiovascular disease. CRP is the final product of the interleukin (IL)-1β/IL-6/CRP axis. Its monomeric form can be
I. Melnikov, S. Kozlov, O. Saburova, Y. Avtaeva, K. Guria, Z. Gabbasov   +5 more
semanticscholar   +3 more sources

C-reactive protein: the nexus between inflammation and protein misfolding diseases [PDF]

Frontiers in Immunology
C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Abhishek Roy, Abhishek Roy, Johannes Zeller, Johannes Zeller, Tracy L. Nero, Tracy L. Nero, Tracy L. Nero, Johanna Klepetko, Steffen U. Eisenhardt, Michael W. Parker, Michael W. Parker, Michael W. Parker, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter   +19 more
doaj   +2 more sources

C-Reactive Protein and Cancer: Interpreting the Differential Bioactivities of Its Pentameric and Monomeric, Modified Isoforms

Frontiers in Immunology, 2021
C-reactive protein (CRP) was first recognized in the 1940s as a protein that appeared in blood during acute episodes of infectious disease. Its presence and pharmacodynamics were found in essentially all diseases that involved tissue damage and ...
Lawrence A. Potempa, Ibraheem M. Rajab, Margaret E. Olson, Peter C. Hart   +3 more
doaj   +2 more sources

Higher monomeric C-reactive protein levels are associated with premature coronary artery disease. [PDF]

Front Immunol
Introduction Chronic inflammation is a major risk factor for coronary artery disease (CAD). Currently, the inflammatory cardiovascular risk is assessed via C-reactive protein (CRP) levels measured using a high-sensitivity assay (hsCRP).
Melnikov I, Kozlov S, Okhota S, Saburova O, Avtaeva Y, Kuznetsova T, Guria K, Prokofieva L, Riazantseva T, Ji SR, Wu Y, Gabbasov Z.   +11 more
europepmc   +2 more sources

The Cholesterol-Binding Sequence in Monomeric C-Reactive Protein Binds to the SARS-CoV-2 Spike Receptor-Binding Domain and Blocks Interaction With Angiotensin-Converting Enzyme 2

Frontiers in Immunology, 2022
The receptor-binding domain (RBD) of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the human angiotensin-converting enzyme 2 (ACE2) receptor, which is a prerequisite for the virus to enter the cell. C-reactive
Hai-yun Li, Hai-yun Li, Ning Gao, Cheng-yang Liu, Xiao-ling Liu, Feng Wu, Nini Dai, Jing Han, Jing Han, Qiu-yu Li   +9 more
doaj   +2 more sources