Results 11 to 20 of about 272,971 (193)

Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP

Journal of Autoimmunity, 2023
The pentraxin C-reactive protein (CRP) is a pentameric protein now known to be able to undergo dissociation into a monomeric, modified isoform, referred to as mCRP. In carefully assessing the bioactivities of each isoform, mCRP has strong pro-inflammatory activities while pCRP has mild anti-inflammatory activities. Systemic lupus erythematosus (SLE) is
Jesper Karlsson, Jonas Wetterö, Lawrence A. Potempa, Rafael Fernandez-Botrán, Yasmine O'Neill, Lina Wirestam, Fariborz Mobarrez, Christopher Sjöwall   +7 more
semanticscholar   +9 more sources

C-reactive protein (CRP) aptamer binds to monomeric but not pentameric form of CRP [PDF]

Analytical and Bioanalytical Chemistry, 2011
Native C-reactive protein (CRP) is composed of five identical subunits arranged in a pentameric structure (pCRP). Binding of pCRP to damaged cell membranes produces a second isoform, modified CRP, which has similar antigenicity to isolated monomeric subunits of CRP (mCRP).
Min S. Wang, Joshua C. Black, Michelle K. Knowles, Scott M. Reed   +3 more
semanticscholar   +7 more sources

Monomeric CRP and negative acute phase proteins, but not pentameric CRP, as biomarkers of major depression and MDMD [PDF]

Acta Neuropsychiatrica
Abstract Background: Contrary to the negative acute-phase protein (APP) response, there is no consistent correlation between serum pentameric C-reactive protein (pCRP) and major depression (MDD). Monomeric CRP (mCRP), a dissociation product of pCRP under immune-inflammatory conditions, exhibits
Abbas F. Almulla, Mengqi Niu, Drozdstoy Stoyanov, Yingqian Zhang, Michaël Maes   +4 more
semanticscholar   +3 more sources

Association of monomeric C-Reactive Protein (m-CRP) with hypothalamic neurons after CRP hippo-campal administration in a model of dementia.

European review for medical and pharmacological sciences, 2022
The ensuing ischemia due to the disruption of blood supply to the brain is one of the most common causes of stroke. Evidence suggests a clear association of the ischemic injury with vascular dementia and Alzheimer's disease (AD). In response to the brain ischemia, a cascade reaction starts leading to neuronal damage due to oxidative stress and other ...
Raid Saleem Al-Baradie, Axam Abdelhadi, F Ahmad, Suliman A. Alsagaby, M Slevin, W Alturaiki, Y Madkhali, B M Aljarallah, M Alqahtani, Mohammad Miraj, I Ahmad, N Albaradie, R Albaradie   +12 more
semanticscholar   +6 more sources

Monomeric CRP and Negative Acute Phase Proteins but not pentameric CRP are biomarkers of major depression and especially major dysmood disorder [PDF]

medRxiv
Abstract Background Contrary to the negative acute-phase protein (APP) response, there is no consistent correlation between serum pentameric C-reactive protein (pCRP) and major depression (MDD). Monomeric CRP (mCRP), a dissociation product of pCRP under immune-inflammatory conditions, exhibits pro-inflammatory
Abbas F. Almulla, Mengqi Niu, Drozdstoy Stoyanov, Yingqian Zhang, Michael Maes   +4 more
semanticscholar   +3 more sources

Author Correction: Association of monomeric C-Reactive Protein (m-CRP) with hypothalamic neurons after CRP hippo-campal administration in a model of dementia.

European review for medical and pharmacological sciences, 2023
Correction to: European Review for Medical and Pharmacological Sciences 2022; 26 (22): 8713-8718. DOI: 10.26355/eurrev_202212_30543- PMID: 36524490-published online on December 15, 2022. After publication, the authors applied a correction to the funding statement: The authors extend their appreciation to the deputyship for Research & Innovation ...
Raid Saleem Al-Baradie, Axam Abdelhadi, F Ahmad, Suliman A. Alsagaby, M Slevin, W Alturaiki, Y Madkhali, B M Aljarallah, M Alqahtani, Mohammad Miraj, I Ahmad, N Albaradie, R Albaradie   +12 more
semanticscholar   +4 more sources

Reduced serum levels of autoantibodies against monomeric C-reactive protein (CRP) in patients with acute coronary syndrome

Clinica Chimica Acta, 2008
Inflammation is pivotal in atherosclerosis. Minor C-reactive protein (CRP) response reflects low-grade vascular inflammation and the high-sensitivity CRP test with levels > or = 3.0 mg/l predicts coronary vascular events and survival in angina pectoris as well as in healthy subjects. We and others recently reported autoantibodies against monomeric CRP (
Jonas Wetterö, Lennart Nilsson, Lena Jonasson, Christopher Sjöwall   +3 more
semanticscholar   +6 more sources

Redefining CRP in tissue injury and repair: more than an acute pro-inflammatory mediator [PDF]

Frontiers in Immunology
Most early studies investigating the role of C-reactive protein (CRP) in tissue damage determined it supported pro-hemostatic and pro-inflammatory activities.
Marc Potempa, Peter C. Hart, Ibraheem M. Rajab, Lawrence A. Potempa, Lawrence A. Potempa   +4 more
doaj   +3 more sources

Circulating Levels of the Proinflammatory Monomeric Isoform of C-Reactive Protein (mCRP) Correlate with Intra-Tumoral mCRP Abundance in Stage II-III Colon Cancer Patients [PDF]

Journal of Inflammation Research
Anniken Jørlo Fuglestad,1– 3 Paula Anna Bousquet,1 Anne Helene Køstner,3 Sebastian Meltzer,1 Britta Kleist,4 Anne Hansen Ree,1,2 Ibraheem M Rajab,5 Lawrence A Potempa,6 Rafael Fernandez-Botran,7 Christian Kersten1,3 1Department of Oncology, Akershus ...
Fuglestad AJ, Bousquet PA, Køstner AH, Meltzer S, Kleist B, Ree AH, Rajab IM, Potempa LA, Fernandez-Botran R, Kersten C   +9 more
doaj   +3 more sources

Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?

Frontiers in Immunology, 2023
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Anne Helene Køstner, Anne Helene Køstner, Anniken Jørlo Fuglestad, Anniken Jørlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten, Christian Kersten   +14 more
doaj   +2 more sources