Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein [PDF]
Frontiers in Immunology, 2020 A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an ...
Robert D. Williams +6 more
doaj +5 more sources
Beyond the Biomarker: Monomeric CRP as a Driver of Multisystem Pathology in Rheumatoid Arthritis [PDF]
International Journal of Molecular SciencesChronic inflammation underpins the pathogenesis of both rheumatoid arthritis (RA) and neurodegenerative conditions such as Alzheimer’s disease (AD). This narrative review explores the role of C-reactive protein (CRP), particularly its monomeric form (mCRP), as a central molecular link connecting systemic autoimmune inflammation with neuroinflammatory ...
Mark Slevin
exaly +4 more sources
Monomeric [CRP] and CRP-Controlled Stress and Pain Hypersensitization as Novel Predictors of Cognitive Disturbance and AD in Chronic Inflammatory Disease [PDF]
International Journal of Molecular SciencesChronic low-grade systemic inflammation is increasingly recognized as a key mediator linking stress, pain sensitivity, and cognitive decline. Central to this process are the acute-phase reactants interleukin-6 (IL-6) and C-reactive protein (CRP), which serve as biomarkers of systemic inflammation while promoting neuroimmune dysregulation.
Mark Slevin
exaly +5 more sources
A Review of Anti-C Reactive Protein Antibodies in Systemic Lupus Erythematosus [PDF]
Journal of Interdisciplinary Medicine, 2021 Systemic lupus erythematosus (SLE), the prototype autoimmune disease, is characterized by the production of a plethora of autoantibodies with various roles in the development of disease-related tissue damage.
Richter Patricia +5 more
doaj +5 more sources
Serum CRP interacts with SPARC and regulate immune response in severe cases of COVID-19 infection [PDF]
Frontiers in Immunology, 2023 Serum C-reactive protein (CRP) has been found elevated during COVID-19 infection, and associated with systematic inflammation as well as a poor clinical outcome.
Chengyang Liu +4 more
doaj +2 more sources
Pentameric C-reactive protein is a better prognostic biomarker and remains elevated for longer than monomeric CRP in hospitalized patients with COVID-19. [PDF]
Front Immunol, 2023 The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Hopkins FR +12 more
europepmc +5 more sources
Redefining CRP in tissue injury and repair: more than an acute pro-inflammatory mediator [PDF]
Frontiers in ImmunologyMost early studies investigating the role of C-reactive protein (CRP) in tissue damage determined it supported pro-hemostatic and pro-inflammatory activities.
Marc Potempa +4 more
doaj +2 more sources
The pentameric, but not the monomeric, isoform of C-reactive protein (CRP) enhances phagocytosis of methicillin-resistant Staphylococcus aureus (MRSA); potential implications for treatment strategies. [PDF]
, 2017 Evidence indicates C-reactive protein (CRP) is not only a marker of infection but has a protective role, principally through the activation of complement and opsonisation of bacterial pathogens.
Hall, NR +3 more
core +3 more sources
Monomeric CRP and negative acute phase proteins, but not pentameric CRP, as biomarkers of major depression and MDMD. [PDF]
Acta NeuropsychiatrAbstract Background: Contrary to the negative acute-phase protein (APP) response, there is no consistent correlation between serum pentameric C-reactive protein (pCRP) and major depression (MDD). Monomeric CRP (mCRP), a dissociation product of pCRP under immune-inflammatory conditions, exhibits
Almulla AF +4 more
europepmc +3 more sources
C-reactive protein isoforms as prognostic markers of COVID-19 severity
Frontiers in Immunology, 2023 C-reactive protein (CRP), an active regulator of the innate immune system, has been related to COVID-19 severity. CRP is a dynamic protein undergoing conformational changes upon activation in inflammatory microenvironments between pentameric and ...
Blanca Molins +12 more
doaj +1 more source