Современные возможности определения и применения в клинике мономера С-реактивного белка [PDF]
Complex Issues of Cardiovascular Diseases, 2020 Aim. To develop a method for measuring circulating monomeric C-reactive protein and to determine the levels of C-reactive protein isoforms (native pentameric C-reactive protein and monomeric C-reactive protein) in patients with stable coronary artery ...
I. S. Melnikov +9 more
core +3 more sources
Role of Ischemic Preconditioning in the Cardioprotective Mechanisms of Monomeric C-Reactive Protein-Deposited Myocardium in a Rat Model [PDF]
Journal of Chest Surgery, 2021 Background: The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI.
Eun Na Kim +4 more
doaj +2 more sources
Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 mitogen-activated protein kinase in human coronary artery endothelial cells [PDF]
Biomolecules & Biomedicine, 2020 C-reactive protein (CRP) is an important predictor of cardiovascular events and plays a role in vascular inflammation and vessel damage. The aim of this study was to investigate the effect of pentameric CRP (pCRP) and monomeric CRP (mCRP) on the ...
Yong Zhang, Hongxia Cao
doaj +2 more sources
Acetylcholine Inhibits Monomeric C-Reactive Protein Induced Inflammation, Endothelial Cell Adhesion, and Platelet Aggregation; A Potential Therapeutic? [PDF]
Frontiers in Immunology, 2018 Objectives: In this study, we examined the possibility of using targeted antibodies and the potential of small molecular therapeutics (acetylcholine, nicotine and tacrine) to block the pro-inflammatory and adhesion-related properties of monomeric C ...
Mark Slevin +18 more
doaj +2 more sources
Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation [PDF]
Frontiers in Immunology, 2018 C-reactive protein (CRP) is an established marker of rheumatoid arthritis (RA) but with ill-defined actions in the pathogenesis. Here, we show that CRP regulates the differentiation of osteoclasts, a central mediator of joint inflammation and bone ...
Zhe-Kun Jia +6 more
doaj +2 more sources
Monomeric C-reactive protein level is associated with osteoarthritis. [PDF]
Exp Ther Med, 2022 Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration and secondary bone hyperplasia. C-reactive protein (CRP) is an acute-phase protein that is widely used as a marker of inflammation. Elevated plasma levels of CRP are commonly observed in patients with OA during the acute phase.
Liang Y +6 more
europepmc +4 more sources
C-Reactive Protein and Cancer: Interpreting the Differential Bioactivities of Its Pentameric and Monomeric, Modified Isoforms [PDF]
Frontiers in Immunology, 2021 C-reactive protein (CRP) was first recognized in the 1940s as a protein that appeared in blood during acute episodes of infectious disease. Its presence and pharmacodynamics were found in essentially all diseases that involved tissue damage and ...
Lawrence A. Potempa +3 more
doaj +3 more sources
The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action. [PDF]
PLoS ONE, 2014 The prototypic acute phase reactant C-reactive protein (CRP) is not only a marker but also a potential contributor to inflammatory diseases. CRP exists as the circulating native, pentameric CRP (pCRP) and the monomeric isoform (mCRP), formed as a result ...
Masaaki Fujita +3 more
doaj +2 more sources
Immunoradiometric assay of circulating C-reactive protein: age-related values in the adult general population [PDF]
, 2000 Background: Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, previously considered to be within the reference interval, are strongly associated with increased risk of atherothrombotic events,
Hutchinson, W.L. +5 more
core +8 more sources
Corrigendum: The cholesterol-binding sequence in monomeric C-reactive protein binds to the SARS-CoV-2 spike receptor-binding domain and blocks interaction with Angiotensin-converting enzyme 2 [PDF]
Frontiers in Immunology, 2022 Hai-yun Li +9 more
doaj +2 more sources