Monomeric C-reactive protein and inflammatory injury in myocardial infarction. [PDF]
Cardiovasc Res, 2012 This editorial refers to ‘Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction’ by J. Habersberger et al. , pp. 64–72, this issue. C-reactive protein, a member of the pentraxin superfamily, is a prototypical ‘acute-phase’ protein that is synthesized at a low rate under physiological ...
Frangogiannis NG.
europepmc +4 more sources
Monomeric C-reactive protein and inflammation in age-related macular degeneration. [PDF]
J Pathol, 2016 AbstractAge‐related macular degeneration (AMD) is a devastating disease characterized by central vision loss in elderly individuals. Previous studies have suggested a link between elevated levels of total C‐reactive protein (CRP) in the choroid, CFH genotype, and AMD status; however, the structural form of CRP present in the choroid, its relationship ...
Chirco KR +7 more
europepmc +4 more sources
Expression of Monomeric C-Reactive Protein in Infarcted Brain Tissue from Patients with Alzheimer’s Disease [PDF]
Türk Patoloji Dergisi, 2017 Objective: We have previously shown that monomeric-C-reactive protein is deposited in significant quantities within the brain parenchyma after stroke. Since we have recently identified a possible role of this protein in supporting neurodegeneration and ...
Mark SLEVIN +5 more
doaj +4 more sources
An Intrinsically Disordered Motif Mediates Diverse Actions of Monomeric C-reactive Protein. [PDF]
J Biol Chem, 2016 Most proinflammatory actions of C-reactive protein (CRP) are only expressed following dissociation of its native pentameric assembly into monomeric form (mCRP). However, little is known about what underlies the greatly enhanced activities of mCRP. Here we show that a single sequence motif, i.e. cholesterol binding sequence (CBS; a.a.
Li HY +11 more
europepmc +4 more sources
Role of Ischemic Preconditioning in the Cardioprotective Mechanisms of Monomeric C-Reactive Protein-Deposited Myocardium in a Rat Model [PDF]
Journal of Chest Surgery, 2021 Background: The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI.
Eun Na Kim +4 more
doaj +2 more sources
C-Reactive Protein and Cancer: Interpreting the Differential Bioactivities of Its Pentameric and Monomeric, Modified Isoforms [PDF]
Frontiers in Immunology, 2021 C-reactive protein (CRP) was first recognized in the 1940s as a protein that appeared in blood during acute episodes of infectious disease. Its presence and pharmacodynamics were found in essentially all diseases that involved tissue damage and ...
Lawrence A. Potempa +3 more
doaj +3 more sources
Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 mitogen-activated protein kinase in human coronary artery endothelial cells [PDF]
Biomolecules & Biomedicine, 2020 C-reactive protein (CRP) is an important predictor of cardiovascular events and plays a role in vascular inflammation and vessel damage. The aim of this study was to investigate the effect of pentameric CRP (pCRP) and monomeric CRP (mCRP) on the ...
Yong Zhang, Hongxia Cao
doaj +2 more sources
Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow [PDF]
Cardiovascular Research, 2011 We previously reported that C-reactive protein bioactivity on thrombogenesis was based on loss of its pentameric symmetry, resulting in formation of monomeric C-reactive protein. Our purpose was to provide mechanistic information on the direct effects of C-reactive protein isoforms on platelet activation and provide a C-reactive protein dissociation ...
Blanca Molins +2 more
exaly +4 more sources
Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation [PDF]
Frontiers in Immunology, 2018 C-reactive protein (CRP) is an established marker of rheumatoid arthritis (RA) but with ill-defined actions in the pathogenesis. Here, we show that CRP regulates the differentiation of osteoclasts, a central mediator of joint inflammation and bone ...
Zhe-Kun Jia +6 more
doaj +2 more sources
Acetylcholine Inhibits Monomeric C-Reactive Protein Induced Inflammation, Endothelial Cell Adhesion, and Platelet Aggregation; A Potential Therapeutic? [PDF]
Frontiers in Immunology, 2018 Objectives: In this study, we examined the possibility of using targeted antibodies and the potential of small molecular therapeutics (acetylcholine, nicotine and tacrine) to block the pro-inflammatory and adhesion-related properties of monomeric C ...
Mark Slevin +18 more
doaj +2 more sources