Frontiers in Immunology, 2021 Phagocytosis and the formation of reactive oxygen species (ROS) in phagocytic leukocytes are an effective killing mechanism of the innate host defense. These cellular processes of innate immunity function in a complex interplay with humoral factors.
Johannes Zeller +11 more
doaj +1 more source
The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop [PDF]
, 2015 Neuroserpin (NS) is an inhibitory protein belonging to the serpin family and involved in several pathologies, including the dementia Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), a genetic neurodegenerative disease caused by ...
Caccia, Sonia +7 more
core +1 more source
Serum CRP interacts with SPARC and regulate immune response in severe cases of COVID-19 infection
Frontiers in Immunology, 2023 Serum C-reactive protein (CRP) has been found elevated during COVID-19 infection, and associated with systematic inflammation as well as a poor clinical outcome.
Chengyang Liu +4 more
doaj +1 more source
Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain [PDF]
, 2016 In response to light, as part of a two-component system, the Brucella blue light-activated histidine kinase (LOV-HK) increases its autophosphorylation, modulating the virulence of this microorganism.
Arrar, Mehrnoosh +9 more
core +1 more source
A Peroxisomal Lon Protease and Peroxisome Degradation by Autophagy Play Key Roles in Vitality of Hansenula polymorpha Cells [PDF]
, 2007 In eukaryote cells various mechanisms exist that are responsible for the removal of non-functional proteins. Here we show that in the yeast Hansenula polymorpha (H.
Bener Aksam, Eda +5 more
core +2 more sources
C-reactive protein: a target for therapy to reduce inflammation
Frontiers in Immunology, 2023 C-reactive protein (CRP) is well-recognized as a sensitive biomarker of inflammation. Association of elevations in plasma/serum CRP level with disease state has received considerable attention, even though CRP is not a specific indicator of a single ...
Salma A. Rizo-Téllez +5 more
doaj +1 more source
A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. [PDF]
, 2018 Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of ...
A Cleasby +47 more
core +2 more sources
A Monomer-to-Trimer Transition of the Human Mitochondrial Transcription Termination Factor (mTERF) Is Associated with a Loss of in Vitro Activity [PDF]
, 2004 The human mitochondrial transcription termination factor (mTERF) is a nuclear-encoded 39-kDa protein that recognizes a mtDNA segment within the mitochondrial tRNALeu(UUR) gene immediately adjacent to and downstream of the 16 S rRNA gene. Binding of mTERF
Asin-Cayuela, Jordi +2 more
core +1 more source
Arabidopsis thaliana dehydroascorbate reductase 2 : conformational flexibility during catalysis [PDF]
, 2017 Dehydroascorbate reductase (DHAR) catalyzes the glutathione (GSH)-dependent reduction of dehydroascorbate and plays a direct role in regenerating ascorbic acid, an essential plant antioxidant vital for defense against oxidative stress.
Bodra, Nandita +8 more
core +1 more source
Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions. [PDF]
, 2011 BackgroundOsteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family and a cytokine with diverse biologic roles.
Arjomandi, Mehrdad +5 more
core +3 more sources