Arabidopsis thaliana dehydroascorbate reductase 2 : conformational flexibility during catalysis [PDF]
, 2017 Dehydroascorbate reductase (DHAR) catalyzes the glutathione (GSH)-dependent reduction of dehydroascorbate and plays a direct role in regenerating ascorbic acid, an essential plant antioxidant vital for defense against oxidative stress.
Bodra, Nandita +8 more
core +1 more source
Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions. [PDF]
, 2011 BackgroundOsteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family and a cytokine with diverse biologic roles.
Arjomandi, Mehrdad +5 more
core +3 more sources
C-reactive protein: a target for therapy to reduce inflammation
Frontiers in Immunology, 2023 C-reactive protein (CRP) is well-recognized as a sensitive biomarker of inflammation. Association of elevations in plasma/serum CRP level with disease state has received considerable attention, even though CRP is not a specific indicator of a single ...
Salma A. Rizo-Téllez +5 more
doaj +1 more source
Genetically encoded fluorescent redox probes. [PDF]
, 2013 Redox processes are involved in almost every cell of the body as a consequence of aerobic life. In the past decades, redox biology has been increasingly recognized as one of the key themes in cell signaling.
Ai, Hui-Wang, Ren, Wei
core +3 more sources
Interaction of the Streptomyces Wbl protein WhiD with the principal sigma factor σHrdB depends on the WhiD [4Fe-4S] cluster [PDF]
, 2020 The bacterial protein WhiD belongs to the Wbl family of iron–sulfur [Fe-S] proteins present only in the actinomycetes. In Streptomyces coelicolor, it is required for the late stages of sporulation, but precisely how it functions is unknown.
Bush, Matthew +4 more
core +1 more source
A Monomer-to-Trimer Transition of the Human Mitochondrial Transcription Termination Factor (mTERF) Is Associated with a Loss of in Vitro Activity [PDF]
, 2004 The human mitochondrial transcription termination factor (mTERF) is a nuclear-encoded 39-kDa protein that recognizes a mtDNA segment within the mitochondrial tRNALeu(UUR) gene immediately adjacent to and downstream of the 16 S rRNA gene. Binding of mTERF
Asin-Cayuela, Jordi +2 more
core +1 more source
Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells [PDF]
Basic Research in Cardiology, 2011 C-reactive protein (CRP) has been linked to the pathogenesis of atherosclerosis. The dissociation of native, pentameric (p)CRP to monomeric (m)CRP on the cell membrane of activated platelets has recently been demonstrated. The dissociation of pCRP to mCRP may explain local pro-inflammatory reactions at the site of developing atherosclerotic plaques. As
Ahrens, I +11 more
openaire +3 more sources
Effect of pre-analytical treatments on bovine milk acute phase proteins [PDF]
, 2016 Background Samples for diagnostic procedures often require some form of pre-analytical preparation for preservation or safe handling during transportation prior to analysis in the laboratory.
Eckersall, Peter David +4 more
core +1 more source
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]
, 2017 Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S. +3 more
core +3 more sources
Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin [PDF]
American Journal of Physiology-Renal Physiology, 2016 Previous studies have shown that complement activation on renal tubular cells is involved in the induction of interstitial fibrosis and cellular injury. Evidence suggests that the tubular cell damage is initiated by the alternative pathway (AP) of complement with properdin having an instrumental role.
O'Flynn, J. +5 more
openaire +4 more sources