Results 111 to 120 of about 21,607,700 (130)
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Current Pharmaceutical Design, 2020
C-reactive Protein (CRP) is an acute phase reactant, belonging to the pentraxin family of proteins. Its level rises up to 1000-fold in response to acute inflammation. High sensitivity CRP level is utilized as an independent biomarker of inflammation and cardiovascular disease. The accumulating data suggests that CRP has two distinct forms.
Sergey Kozlov
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C-reactive Protein (CRP) is an acute phase reactant, belonging to the pentraxin family of proteins. Its level rises up to 1000-fold in response to acute inflammation. High sensitivity CRP level is utilized as an independent biomarker of inflammation and cardiovascular disease. The accumulating data suggests that CRP has two distinct forms.
Sergey Kozlov
exaly +3 more sources
Monomeric C-reactive protein regulates fibronectin mediated monocyte adhesion
Molecular Immunology, 2020The acute phase reactant C-reactive protein (CRP) binds with high affinity to fibronectin (FN), but this binding occurs only at pH 6.5 or lower, and the binding is inhibited by calcium ions at physiological pH. Since CRP in the circulating blood exists in a calcium-binding form, the interaction between CRP and FN in vivo has been uncertain.
Haiyun Li
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Two-dimensional crystallization of rabbit C-reactive protein monomeric subunits
Acta Crystallographica Section D: Biological Crystallography, 2003C-reactive protein (CRP) is one of the most characteristic acute-phase proteins. Modified CRP is the monomeric form of native CRP and has recently been suggested to exist under physiological conditions. In the current work, CRP subunits were separated from stock CRP solution by size-exclusion chromatography.
Sen-Fang Sui, Shang-Rong Ji
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Anti-Monomeric C-Reactive Protein Antibody Ameliorates Arthritis and Nephritis in Mice
The Journal of Immunology, 2021Abstract Conformation-specific Ags are ideal targets for mAb-based immunotherapy. Here, we demonstrate that the monomeric form of C-reactive protein (mCRP) is a specific therapeutic target for arthritis and nephritis in a murine model. Screening of >1800 anti-mCRP mAb clones identified 3C as a clone recognizing the monomeric, but ...
Chitose Fujita +5 more
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Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow [PDF]
Cardiovascular Research, 2011 We previously reported that C-reactive protein bioactivity on thrombogenesis was based on loss of its pentameric symmetry, resulting in formation of monomeric C-reactive protein. Our purpose was to provide mechanistic information on the direct effects of C-reactive protein isoforms on platelet activation and provide a C-reactive protein dissociation ...
Lina Badimon +2 more
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Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes
Laboratory Investigation, 2021C-reactive protein (CRP) is an acute-phase protein that is used as an established biomarker to follow disease severity and progression in a plethora of inflammatory diseases. However, its pathophysiologic mechanisms of action are still poorly defined and remain elusive. CRP, in its pentameric form, exhibits weak anti-inflammatory activity.
Clara Ruiz-Fernández +12 more
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Mechanisms of monomeric C Reactive Protein inducing neurodegeneration
2020EU-COP 2014-2020, CRP-SAD, ID: P_37_674, MySMIS code: 103432, contract: 51/05.09.2016; SAF2016‐77703, MINECO and ERDF; 2017-SGR-106, AGAUR.
García-Lara, Elisa +5 more
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Monomeric C‐reactive protein modulates classic complement activation on necrotic cells
The FASEB Journal, 2011ABSTRACT The acute‐phase protein C‐reactive protein (CRP) recruits C1q to the surface of damaged cells and thereby initiates complement activation. However, CRP also recruits complement inhibitors, such as C4b‐binding protein (C4bp) and factor H, which both block complement progression at the level of C3 and ...
Mihlan, M. +7 more
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Antibodies against monomeric C-reactive protein – a promising biomarker of lupus nephritis?
Clinical Biochemistry, 2017A significant incidence of systemic lupus erythematosus (SLE), the severity of lupus nephritis and varying responses to treatment rationalize the search for novel biomarkers of disease activity. The aim of the study was to assess whether antibodies against monomeric C reactive protein (anti-mCRP) are associated with the presence of lupus nephritis ...
Katarzyna Jakuszko +7 more
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Conversion of native oligomeric to a modified monomeric form of human C-reactive protein
The International Journal of Biochemistry & Cell Biology, 1998C-reactive protein (CRP) is a pentameric oligoprotein composed of identical 23 kD subunits which can be modified by urea-chelation treatment to a form resembling the free subunit termed modified CRP (mCRP). mCRP has distinct physicochemical, antigenic, and biologic activities compared to CRP. The conditions under which CRP is converted to mCRP, and the
J J, Kresl, L A, Potempa, B E, Anderson
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