Results 141 to 150 of about 85,555 (244)

Monomeric C-reactive protein in coronary artery disease

Complex Issues of Cardiovascular Diseases, 2020
M. D. Zvereva, O. S. Saburova, I. S. Melnikov, S. G. Kozlov, Z. A. Gabbasov   +4 more
openaire   +2 more sources

Biomimetic Nanoparticle Delivering Colchicine to Target Endothelial Inflammation for Atherosclerosis Treatment

Advanced NanoBiomed Research, EarlyView.
Platelet membrane‐coated layered double hydroxide nanoparticles were engineered to target inflamed endothelium at early‐stage atherosclerosis and enhance therapeutic efficacy. The biomimetic platform improves stability, immune escape, and inflamed vascular cell targeting, resulting in reduced oxidative stress and downregulated adhesion molecules.
Xiuwen Zhang, Lingqing Zong, Ashish Misra, Sanjay Patel, Zi Gu   +4 more
wiley   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423

, 2018
Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit
Börsch, Michael, Glick, Gary D., Starke, Ilka   +2 more
core   +1 more source

Editorial: C-Reactive Protein in Age-Related Disorders, Volume II

Frontiers in Immunology, 2022
Mark Slevin, Mark Slevin, Mark Slevin, Blanca Molins   +3 more
doaj   +1 more source

Structure and non-reactive dynamics of the dimeric catalytic domain of human carbonic anhydrase IX

Chemical Physics Impact
Despite the availability of high resolution crystal structure of the catalytic domain of human carbonic anhydrase IX (denoted as HCA IX-c), its solution structure and functional dynamics are mostly unknown.
Divya Rai, Srabani Taraphder
doaj   +1 more source

Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease? [PDF]

Aging Cell, 2021
Zhang Z, Na H, Gan Q, Tao Q, Alekseyev Y, Hu J, Yan Z, Yang JB, Tian H, Zhu S, Li Q, Rajab IM, Blusztajn JK, Wolozin B, Emili A, Zhang X, Stein T, Potempa LA, Qiu WQ.   +18 more
europepmc   +1 more source

Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1 [PDF]

, 1997
CD4 is the primary receptor for human immunodeficiency virus (HIV). The binding site for the surface glycoprotein of HIV type 1 (HIV-1), gp120, has been mapped to the C'-C" region of domain 1 of CD4. Previously, we have shown that a mutant of rat CD4, in
Barclay, A.N., James, W., Puklavec, M., Sattentau, Q.J., Signoret, N., Simon, J.H.M, Somoza, C., Stumbles, P.A.   +7 more
core   +1 more source

C-reactive protein: the nexus between inflammation and protein misfolding diseases

Frontiers in Immunology
C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Abhishek Roy, Abhishek Roy, Johannes Zeller, Johannes Zeller, Tracy L. Nero, Tracy L. Nero, Tracy L. Nero, Johanna Klepetko, Steffen U. Eisenhardt, Michael W. Parker, Michael W. Parker, Michael W. Parker, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter   +19 more
doaj   +1 more source

Autoimmune Thyroiditis Mitigates the Effect of Metformin on Plasma Prolactin Concentration in Men with Drug-Induced Hyperprolactinemia

Pharmaceuticals
Metformin inhibits the secretory function of overactive anterior pituitary cells, including lactotropes. In women of childbearing age, this effect was absent if they had coexisting autoimmune (Hashimoto) thyroiditis.
Robert Krysiak, Marcin Basiak, Witold Szkróbka, Bogusław Okopień   +3 more
doaj   +1 more source