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The Evolution, Oligomerization, Function, and Action Mechanism of α2-Macroglobulin. [PDF]
Xie W, Gao L, Deng H, Liu D, Pang Q.
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Polymeric α‐Hairpinin Allergens Induce a Functional Response via a Single Antibody
Allergy, EarlyView.
Gage O. Leighton +16 more
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Evolutionary divergence of nocturnin led to redox regulation in mammalian orthologs. [PDF]
Olivas-Rasmussen CA +3 more
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Cleavage at the nsp5-nsp6 site of SARS-CoV-2 main protease intermediate precursor is faster from a monomer than a dimer form. [PDF]
Aniana A +5 more
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Acetylcholine Reduces Monomeric C-Reactive Protein Pro-Inflammatory Activity
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Monomeric C-reactive protein regulates fibronectin mediated monocyte adhesion
Molecular Immunology, 2020The acute phase reactant C-reactive protein (CRP) binds with high affinity to fibronectin (FN), but this binding occurs only at pH 6.5 or lower, and the binding is inhibited by calcium ions at physiological pH. Since CRP in the circulating blood exists in a calcium-binding form, the interaction between CRP and FN in vivo has been uncertain.
Hai-Yun Li
exaly +3 more sources
Current Pharmaceutical Design, 2020
C-reactive Protein (CRP) is an acute phase reactant, belonging to the pentraxin family of proteins. Its level rises up to 1000-fold in response to acute inflammation. High sensitivity CRP level is utilized as an independent biomarker of inflammation and cardiovascular disease. The accumulating data suggests that CRP has two distinct forms.
Sergey Kozlov, Yuliya Avtaeva
exaly +3 more sources
C-reactive Protein (CRP) is an acute phase reactant, belonging to the pentraxin family of proteins. Its level rises up to 1000-fold in response to acute inflammation. High sensitivity CRP level is utilized as an independent biomarker of inflammation and cardiovascular disease. The accumulating data suggests that CRP has two distinct forms.
Sergey Kozlov, Yuliya Avtaeva
exaly +3 more sources
Two-dimensional crystallization of rabbit C-reactive protein monomeric subunits
Acta Crystallographica Section D: Biological Crystallography, 2003C-reactive protein (CRP) is one of the most characteristic acute-phase proteins. Modified CRP is the monomeric form of native CRP and has recently been suggested to exist under physiological conditions. In the current work, CRP subunits were separated from stock CRP solution by size-exclusion chromatography.
Shang-Rong Ji, Sen-Fang Sui
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Anti-Monomeric C-Reactive Protein Antibody Ameliorates Arthritis and Nephritis in Mice
The Journal of Immunology, 2021Abstract Conformation-specific Ags are ideal targets for mAb-based immunotherapy. Here, we demonstrate that the monomeric form of C-reactive protein (mCRP) is a specific therapeutic target for arthritis and nephritis in a murine model. Screening of >1800 anti-mCRP mAb clones identified 3C as a clone recognizing the monomeric, but ...
Chitose Fujita +5 more
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