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Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes
Laboratory Investigation, 2021C-reactive protein (CRP) is an acute-phase protein that is used as an established biomarker to follow disease severity and progression in a plethora of inflammatory diseases. However, its pathophysiologic mechanisms of action are still poorly defined and remain elusive. CRP, in its pentameric form, exhibits weak anti-inflammatory activity.
Clara Ruiz-Fernández +12 more
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Monomeric C‐reactive protein modulates classic complement activation on necrotic cells
The FASEB Journal, 2011ABSTRACT The acute‐phase protein C‐reactive protein (CRP) recruits C1q to the surface of damaged cells and thereby initiates complement activation. However, CRP also recruits complement inhibitors, such as C4b‐binding protein (C4bp) and factor H, which both block complement progression at the level of C3 and ...
Mihlan, M. +7 more
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Antibodies against monomeric C-reactive protein – a promising biomarker of lupus nephritis?
Clinical Biochemistry, 2017A significant incidence of systemic lupus erythematosus (SLE), the severity of lupus nephritis and varying responses to treatment rationalize the search for novel biomarkers of disease activity. The aim of the study was to assess whether antibodies against monomeric C reactive protein (anti-mCRP) are associated with the presence of lupus nephritis ...
Katarzyna Jakuszko +7 more
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Conversion of native oligomeric to a modified monomeric form of human C-reactive protein
The International Journal of Biochemistry & Cell Biology, 1998C-reactive protein (CRP) is a pentameric oligoprotein composed of identical 23 kD subunits which can be modified by urea-chelation treatment to a form resembling the free subunit termed modified CRP (mCRP). mCRP has distinct physicochemical, antigenic, and biologic activities compared to CRP. The conditions under which CRP is converted to mCRP, and the
J J, Kresl, L A, Potempa, B E, Anderson
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Monomeric C-reactive protein alters fibrin clot properties on endothelial cells
Thrombosis Research, 2012Elevated plasma levels of C-reactive protein (CRP) are independently associated with increased risk of atherothrombosis. Several lines of evidence suggest that CRP has prothrombogenic effects on injured vessel wall(s) by enhancing tissue factor (TF) expression. Abnormal fibrin formation is correlated with increased thrombotic risk.
Rong, Li +6 more
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FUNCTIONAL ACTIVITY OF MONOMERIC C-REACTIVE PROTEIN IN INTERVERTEBRAL DISC
Orthopaedic ProceedingsMonomeric C reactive protein (mCRP) presents important proinflammatory effects in endothelial cells, leukocytes, or chondrocytes. However, CRP in its pentameric form exhibits weak anti-inflammatory activity. It is used as a biomarker to follow severity and progression in infectious or inflammatory diseases, such as intervertebral disc degeneration ...
C. Ruiz-Fernández +8 more
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Monomeric C reactive Protein Promotes Platelet Activation In Vitro and In Vivo
Heart, Lung and Circulation, 2009J. Habersberger +6 more
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Dissociation of Pentameric to Monomeric C-Reactive Protein Localizes and Aggravates Inflammation
Circulation, 2014Jan R Thiele +2 more
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