Results 121 to 130 of about 272,971 (193)

Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation [PDF]

, 2019
Background Accurate protein quantification is a vital prerequisite for generating meaningful predictions when using systems biology approaches, a method that is increasingly being used to unravel the complexities of sub cellular interactions and as part
Bye, Alexander P., Di, Ying, Dunster, Joanne L., García, Ángel, Gibbins, Jonathan M., Haining, Elizabeth J,, Hardy, Alexander T., Nieswandt, Bernhard, Pallini, Chiara, Pike, Jeremy A., Pollitt, Alice Y., Poulter, Natalie S., Sage, Tanya, Sowa, Marcin A., Unsworth, Amanda J., Watson, Steve P.   +15 more
core   +4 more sources

Two Forms of C-Reactive Protein and Their Implication for Atherogenesis: Focus on Monomeric Form

Journal of Angiotherapy
In this review, we discuss the role of C-reactive protein (CRP), a biomarker of inflammation, in the development of atherosclerosis. CRP exists in two forms: the native pentameric form (nCRP) and the non-native form (mCRP), which is formed during ...

semanticscholar   +1 more source

The Non-Structural NS1 Protein Unique to Respiratory Syncytial Virus: A Two-State Folding Monomer in Quasi-Equilibrium with a Stable Spherical Oligome [PDF]

, 2013
Human respiratory syncytial virus (hRSV) is a major infectious agent that cause pediatric respiratory disease worldwide. Considered one of the main virulence factors of hRSV, NS1 is known to suppress type I interferon response and signaling, thus ...
Camporeale, Gabriela, de Prat Gay, Gonzalo, Pretel, Miguel Esteban   +2 more
core   +1 more source

Monomeric C‐reactive protein exacerbates choroidal neovascularization in vivo: Implications for age‐related macular degeneration

Acta ophthalmologica
Aims/Purpose: Increased systemic levels of the acute phase reactant C‐reactive protein (CRP) have been linked to increased risk of age‐related macular degeneration (AMD).
P. Fernández-Robredo, María Hernández, Sara Romero-Vázquez, S. Recalde, J. Bezunartea, Maite Moreno Orduña, A. Layana, Alfredo Adan, B. Molins   +8 more
semanticscholar   +1 more source

A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation

BMC Biology
Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune ...
Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang   +17 more
doaj   +1 more source

Zinc(II)-methimazole complexes: synthesis and reactivity [PDF]

, 2015
The tetrahedral S-coordinated complex [Zn(MeImHS)(4)](ClO4)(2), synthesised from the reaction of [Zn(ClO4)(2)] with methimazole (1-methyl-3H-imidazole-2-thione, MeImHS), reacts with triethylamine to yield the homoleptic complex [Zn(MeImS)(2)] (MeImS ...
Aragoni M C, Arca M, Bettoschi A, Caltagirone C, Castellano C, Demartin F, Isaia F, Lippolis V, Pivetta T, Valletta E   +9 more
core   +1 more source

Analysis of the interaction of calcitriol with the disulfide isomerase ERp57 [PDF]

, 2016
Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane- associated receptor, which has been discovered as the ...
Altieri, Fabio, Cervoni, Laura, Chichiarelli, Silvia, Eufemi, Margherita, Gaucci, Elisa, Grillo, Caterina, Nittari, Giulio, Raimondo, Domenico   +7 more
core   +1 more source

A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury

Frontiers in Immunology, 2018
IntroductionC-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation.
Jan R. Thiele, Johannes Zeller, Jurij Kiefer, David Braig, Sheena Kreuzaler, Yvonne Lenz, Lawrence A. Potempa, Florian Grahammer, Florian Grahammer, Tobias B. Huber, Tobias B. Huber, Tobias B. Huber, M. Huber-Lang, Holger Bannasch, G. Björn Stark, Karlheinz Peter, Steffen U. Eisenhardt   +16 more
doaj   +1 more source

Effect of bilberry juice on indices of muscle damage and inflammation in runners completing a half-marathon: a randomised, placebo-controlled trial. [PDF]

, 2018
Background: Emerging evidence indicates that fruits rich in polyphenols may attenuate exercise-induced muscle damage and associated markers of inflammation and soreness.
A Karlsen, AL Mackey, AM Batterham, Anna C. Hall, Anthony Lynn, DA Connolly, G Howatson, G Howatson, GL Close, GL Warren, J Cohen, J Lee, JL Bowtell, JM Koponen, JN Cobley, JR Trombold, JR Trombold, K Nosaka, KS Kuehl, M Kolehmainen, Mayur K. Ranchordas, MB Reid, Nichola Nelson, PG Bell, PG Bell, PM Clarkson, RD Hyldahl, S Triebel, Samantha Garner, Spinreact, T Gorski, T Kirkwood, Trevor N. Simper, VLRJ Singleton, WG Hopkins, Y Kobayashi   +35 more
core   +1 more source

C-Reactive Protein as a Therapeutic Target in Age-Related Macular Degeneration

Frontiers in Immunology, 2018
Age-related macular degeneration (AMD), a retinal degenerative disease, is the leading cause of central vision loss among the elderly population in developed countries and an increasing global burden.
Blanca Molins, Sara Romero-Vázquez, Pablo Fuentes-Prior, Pablo Fuentes-Prior, Alfredo Adan, Andrew D. Dick, Andrew D. Dick, Andrew D. Dick   +7 more
doaj   +1 more source