Results 1 to 10 of about 2,128 (105)

The PA2803-Encoded PcrP Exhibits a Novel Non-Catalytic Function and Contributes to Polymyxin B Resistance in P. Aeruginosa. [PDF]

Journal of Bacteriology
The opportunistic human pathogen Pseudomonas aeruginosa (Pa), a leading cause of severe infections, becomes increasingly resistant to antibiotics, including the last resort antibiotic, polymyxin B (PMB). Previous studies have shown that calcium (Ca2+) at
Marianna A Patrauchan, Tarosha Salpadoru
exaly   +4 more sources

Redefining CRP in Tissue Injury and Repair: More Than an Acute Pro-Inflammatory Mediator [PDF]

Frontiers in Immunology
Most early studies investigating the role of C-reactive protein (CRP) in tissue damage determined it supported pro-hemostatic and pro-inflammatory activities.
Peter Hart, Ibraheem Rajab
exaly   +4 more sources

Human Fcγ-receptors selectively respond to C-reactive protein isoforms [PDF]

Frontiers in Immunology
IntroductionThe pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ ...
Anna Henning, Johanna Seer, Johannes Zeller, Karlheinz Peter, Karlheinz Peter, Haizhang Chen, Julia Thomé, Philipp Kolb, Steffen U. Eisenhardt, Katja Hoffmann, Hartmut Hengel   +10 more
doaj   +2 more sources

C-reactive protein: the nexus between inflammation and protein misfolding diseases [PDF]

Frontiers in Immunology
C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Abhishek Roy, Abhishek Roy, Johannes Zeller, Johannes Zeller, Tracy L. Nero, Tracy L. Nero, Tracy L. Nero, Johanna Klepetko, Steffen U. Eisenhardt, Michael W. Parker, Michael W. Parker, Michael W. Parker, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter   +19 more
doaj   +2 more sources

C-reactive protein dissociation drives choroidal neovascularization in age-related macular degeneration [PDF]

Scientific Reports
Choroidal neovascularization (CNV) and inflammation play an important role in retinal disease development and the acute phase reactant C-reactive protein (CRP) has been shown to contribute to Age-related macular degeneration (AMD) in vitro.
Maria Hernandez, Sara Romero-Vázquez, Sergio Recalde, Jaione Bezunartea, Maite Moreno Orduña, Idoia Belza-Zuazu, Alfredo García-Layana, Alfredo Adán, Patricia Fernández-Robredo, Blanca Molins   +9 more
doaj   +2 more sources

Monomeric CRP is prevalent in the blood of patients with rheumatoid arthritis and correlates with clinically relevant markers [PDF]

Frontiers in Immunology
IntroductionElevated C-reactive protein (CRP) is a hallmark of rheumatoid arthritis (RA) flares. CRP exists as pentameric (pCRP) and monomeric (mCRP) isoforms with distinct functions, with pCRP generally pro-inflammatory and mCRP more immunomodulatory ...
Alexia Correia Ferreira, Lucia Martin-Gutierrez, Christophe Lalaurie, Karen Feehan, Priyanka Lakhani, Imogen Buckle, George A. Robinson, Elizabeth C. Jury, Jessica J. Manson, Jessica J. Manson, Thomas C. R. McDonnell   +10 more
doaj   +2 more sources

C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions [PDF]

Frontiers in Immunology
IntroductionC-reactive protein (CRP) plays a critical role in the innate immune system and serves as a biomarker for various inflammatory conditions. CRP is a dynamic protein undergoing conformational changes between pentameric (pCRP) and monomeric (mCRP)
Mercedes S. Nabaes Jodar, Víctor Llorenç, Víctor Llorenç, Marc Figueras-Roca, Marc Figueras-Roca, Maite Sainz de-la-Maza, Maite Sainz de-la-Maza, Alfredo Adán, Alfredo Adán, Blanca Molins   +9 more
doaj   +2 more sources

C-reactive protein in cardiovascular disease: clinical associations, conformation-dependent biology, and therapeutic perspectives [PDF]

Frontiers in Immunology
C-reactive protein (CRP) is a widely used biomarker of systemic inflammation and cardiovascular risk. Its clinical and experimental relevance has been investigated across major cardiovascular disease (CVD) phenotypes, including coronary artery disease ...
Bingxing Gong, Haiqin Xu, Honglan Liu, Mengmeng Wang, Kailin Yang, Junpeng Chen, Xiaoyang Guo, Tianqing Zhang, Liangqing Ge   +8 more
doaj   +2 more sources

A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury

Frontiers in Immunology, 2018
IntroductionC-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation.
Tobias B Huber, Jurij Kiefer, David Braig   +2 more
exaly   +3 more sources

Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes

Frontiers in Immunology, 2018
C-reactive protein (CRP) is a member of the pentraxin superfamily that is widely recognized as a marker of inflammatory reactions and cardiovascular risk in humans.
Jurij Kiefer, David Braig, Karlheinz Peter   +2 more
exaly   +3 more sources