The PA2803-encoded PcrP exhibits a novel non-catalytic function and contributes to polymyxin B resistance in P. aeruginosa [PDF]
Journal of BacteriologyThe opportunistic human pathogen Pseudomonas aeruginosa (Pa), a leading cause of severe infections, becomes increasingly resistant to antibiotics, including the last resort antibiotic, polymyxin B (PMB). Previous studies have shown that calcium (Ca2+) at
T. Salpadoru +12 more
exaly +6 more sources
pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics [PDF]
Frontiers in Immunology, 2018 Circulating C-reactive protein (CRP) is a key acute-phase protein and one of the main clinical biomarkers for inflammation and infection. CRP is an important upstream mediator of inflammation and is associated with the onset of a number of important ...
Mario di Napoli +2 more
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Redefining CRP in tissue injury and repair: more than an acute pro-inflammatory mediator [PDF]
Frontiers in ImmunologyMost early studies investigating the role of C-reactive protein (CRP) in tissue damage determined it supported pro-hemostatic and pro-inflammatory activities.
Peter Hart, Ibraheem Rajab
exaly +4 more sources
PCRP: Unsupervised Point Cloud Object Retrieval and Pose Estimation
2022 IEEE International Conference on Image Processing (ICIP), 2022 8 pages, 3 ...
Pranav Kadam +2 more
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The NIH Protein Capture Reagents Program (PCRP): a standardized protein affinity reagent toolbox [PDF]
Nature Methods, 2016 The NIH Protein Capture Reagents Program (PCRP): a standardized protein affinity reagent ...
Anand Venkataraman +2 more
exaly +3 more sources
Pancreatic cancer-related pain: mechanism and management
Journal of Pancreatology, 2023 Pancreatic cancer-related pain (PCRP) gains widespread attention for its high prevalence, extreme complexity, poor prognosis, and decreased survival rate. Current treatment of PCRP remains unsatisfactory since the underlying mechanism is not clear.
Le Shen, Afang Zhu
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Human Fcγ-receptors selectively respond to C-reactive protein isoforms [PDF]
Frontiers in ImmunologyIntroductionThe pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ ...
Anna Henning +10 more
doaj +2 more sources
C-reactive protein: the nexus between inflammation and protein misfolding diseases [PDF]
Frontiers in ImmunologyC-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Abhishek Roy +19 more
doaj +2 more sources
C-reactive protein dissociation drives choroidal neovascularization in age-related macular degeneration [PDF]
Scientific ReportsChoroidal neovascularization (CNV) and inflammation play an important role in retinal disease development and the acute phase reactant C-reactive protein (CRP) has been shown to contribute to Age-related macular degeneration (AMD) in vitro.
Maria Hernandez +9 more
doaj +2 more sources
C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions [PDF]
Frontiers in ImmunologyIntroductionC-reactive protein (CRP) plays a critical role in the innate immune system and serves as a biomarker for various inflammatory conditions. CRP is a dynamic protein undergoing conformational changes between pentameric (pCRP) and monomeric (mCRP)
Mercedes S. Nabaes Jodar +9 more
doaj +2 more sources