Results 31 to 40 of about 2,447 (150)

mCRP as a Biomarker of Adult-Onset Still’s Disease: Quantification of mCRP by ELISA

Frontiers in Immunology, 2022
BackgroundC-reactive protein (CRP) is a dynamic protein that undergoes conformational changes between circulating native pentameric CRP (pCRP), pentameric symmetrical forms (pCRP*) and monomeric (or modified) CRP (mCRP) forms.
Chitose Fujita, Chitose Fujita, Yasuo Sakurai, Yasuo Sakurai, Yuki Yasuda, Rino Homma, Cheng-Long Huang, Cheng-Long Huang, Masaaki Fujita, Masaaki Fujita, Masaaki Fujita, Masaaki Fujita   +11 more
doaj   +1 more source

CRP Is Transported by Monocytes and Monocyte-Derived Exosomes in the Blood of Patients with Coronary Artery Disease

Biomedicines, 2020
The objective of this work was to study the ability of blood cells and their microparticles to transport monomeric and pentameric forms of C-reactive protein (mCRP and pCRP) in the blood of patients with coronary artery disease (CAD).
Ivan Melnikov, Sergey Kozlov, Olga Saburova, Ekaterina Zubkova, Olga Guseva, Sergey Domogatsky, Tatiana Arefieva, Natalia Radyukhina, Maria Zvereva, Yuliya Avtaeva, Lyudmila Buryachkovskaya, Zufar Gabbasov   +11 more
doaj   +1 more source

Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 mitogen-activated protein kinase in human coronary artery endothelial cells

Biomolecules & Biomedicine, 2020
C-reactive protein (CRP) is an important predictor of cardiovascular events and plays a role in vascular inflammation and vessel damage. The aim of this study was to investigate the effect of pentameric CRP (pCRP) and monomeric CRP (mCRP) on the ...
Yong Zhang, Hongxia Cao
doaj   +1 more source

Relevance of lipoproteins, membranes, and extracellular vesicles in understanding C-reactive protein biochemical structure and biological activities

Frontiers in Cardiovascular Medicine, 2022
Early purification protocols for C-reactive protein (CRP) often involved co-isolation of lipoproteins, primarily very low-density lipoproteins (VLDLs).
Lawrence A. Potempa, Wei Qiao Qiu, Wei Qiao Qiu, Wei Qiao Qiu, Ashley Stefanski, Ibraheem M. Rajab   +5 more
doaj   +1 more source

Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells [PDF]

, 2011
C-reactive protein (CRP) has been linked to the pathogenesis of atherosclerosis. The dissociation of native, pentameric (p)CRP to monomeric (m)CRP on the cell membrane of activated platelets has recently been demonstrated.
C. Bode, Ahrens, Ingo, Topcic, D., Haviv, I, Peter, Karlheinz, Peter, K, K. Peter, Domeij, Helena, M. Lappas, Eisenhardt, Steffen Ulrich, Viitaniemi, K, H. Domeij, Ahrens, I, D. Topcic, M. Albrecht, Albrecht, M, Jowett, JB, Leitner, Ephraem, Bode, C, Bode, Christoph, S. U. Eisenhardt, Domeij, H, I. Haviv, Topcic, D, Viitaniemi, K., I. Ahrens, Lappas, Martha, E. Leitner, Leitner, E, Jowett, J. B., Lappas, M, K. Viitaniemi, J. B. Jowett, Albrecht, Madlin, Eisenhardt, SU, Haviv, Izhak   +35 more
core   +1 more source

Incidence and Impact of Routine Inflammatory Parameters on Outcome after Transcatheter Aortic Valve Replacement

Journal of Interventional Cardiology, 2021
Background. Previous research reported adverse clinical outcomes in association with systemic inflammation (SI) after transcatheter aortic valve replacement (TAVR).
Polykarpos C Patsalis, Assem Aweimer, Henrik Scharkowski, Dritan Useini, Peter Lukas Haldenwang, Justus Thomas Strauch, Ali Canbay, Andreas Mügge, Antonios Katsounas   +8 more
doaj   +1 more source

C-reactive protein, immunothrombosis and venous thromboembolism

Frontiers in Immunology, 2022
C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical practice as a marker of infection and inflammation.
Caroline Dix, Caroline Dix, Johannes Zeller, Johannes Zeller, Hannah Stevens, Hannah Stevens, Hannah Stevens, Steffen U. Eisenhardt, Karen S. Cheung Tung Shing, Karen S. Cheung Tung Shing, Tracy L. Nero, Tracy L. Nero, Craig J. Morton, Craig J. Morton, Craig J. Morton, Michael W. Parker, Michael W. Parker, Michael W. Parker, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen   +24 more
doaj   +1 more source

Surface-immobilization of pCRP induced the formation of an intermediate with dual antigenicity.

, 2018
(A) a.a.22-45 (recognized by 8C10; orange) is mostly packed inside the subunit in pCRP (PDB ID: 1B09), while a.a.199-206 (recognized by 3H12; green) lies at the subunit interface of the pentamer.
Jian-Min Lv (5324774), Ming-Yu Wang (598434)   +1 more
core   +1 more source

The intermediate formed on hydrophobic surfaces binds the solution-phase pCRP in a calcium-dependent manner with high affinity.

, 2018
(A) Binding of biotin-labeled pCRP to pCRP (5 μg/ml) immobilized in TBS-Ca (pH 7.4) overnight at 4°C. Biotin-labeled pCRP bound immobilized pCRP in a calcium-dependent fashion. **p d for the homo-complex formation of pCRP (~1.5 nM vs. ~20 μM).
Jian-Min Lv (5324774), Ming-Yu Wang (598434)   +1 more
core   +1 more source

Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?

Frontiers in Immunology, 2023
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Anne Helene Køstner, Anne Helene Køstner, Anniken Jørlo Fuglestad, Anniken Jørlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten, Christian Kersten   +14 more
doaj   +1 more source