Results 31 to 40 of about 2,499 (154)

Pentameric C-reactive protein is a better prognostic biomarker and remains elevated for longer than monomeric CRP in hospitalized patients with COVID-19

Frontiers in Immunology, 2023
The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome ...
Francis R. Hopkins, Johan Nordgren, Rafael Fernandez-Botran, Helena Enocsson, Melissa Govender, Cecilia Svanberg, Lennart Svensson, Lennart Svensson, Marie Hagbom, Åsa Nilsdotter-Augustinsson, Åsa Nilsdotter-Augustinsson, Sofia Nyström, Sofia Nyström, Christopher Sjöwall, Johanna Sjöwall, Johanna Sjöwall, Marie Larsson   +16 more
doaj   +1 more source

Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis [PDF]

, 2019
The research described here considers molecular variations of the acute phase response protein, C reactive protein (CRP), and the presence of CRP and anti CRP autoantibodies in rheumatoid arthritis (RA) patient serum.Monomeric CRP (mCRP) was generated in
Moran, Jennifer Ann
core   +5 more sources

mCRP as a Biomarker of Adult-Onset Still’s Disease: Quantification of mCRP by ELISA

Frontiers in Immunology, 2022
BackgroundC-reactive protein (CRP) is a dynamic protein that undergoes conformational changes between circulating native pentameric CRP (pCRP), pentameric symmetrical forms (pCRP*) and monomeric (or modified) CRP (mCRP) forms.
Chitose Fujita, Chitose Fujita, Yasuo Sakurai, Yasuo Sakurai, Yuki Yasuda, Rino Homma, Cheng-Long Huang, Cheng-Long Huang, Masaaki Fujita, Masaaki Fujita, Masaaki Fujita, Masaaki Fujita   +11 more
doaj   +1 more source

Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 mitogen-activated protein kinase in human coronary artery endothelial cells

Biomolecules & Biomedicine, 2020
C-reactive protein (CRP) is an important predictor of cardiovascular events and plays a role in vascular inflammation and vessel damage. The aim of this study was to investigate the effect of pentameric CRP (pCRP) and monomeric CRP (mCRP) on the ...
Yong Zhang, Hongxia Cao
doaj   +1 more source

Relevance of lipoproteins, membranes, and extracellular vesicles in understanding C-reactive protein biochemical structure and biological activities

Frontiers in Cardiovascular Medicine, 2022
Early purification protocols for C-reactive protein (CRP) often involved co-isolation of lipoproteins, primarily very low-density lipoproteins (VLDLs).
Lawrence A. Potempa, Wei Qiao Qiu, Wei Qiao Qiu, Wei Qiao Qiu, Ashley Stefanski, Ibraheem M. Rajab   +5 more
doaj   +1 more source

C-reactive protein, immunothrombosis and venous thromboembolism

Frontiers in Immunology, 2022
C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical practice as a marker of infection and inflammation.
Caroline Dix, Caroline Dix, Johannes Zeller, Johannes Zeller, Hannah Stevens, Hannah Stevens, Hannah Stevens, Steffen U. Eisenhardt, Karen S. Cheung Tung Shing, Karen S. Cheung Tung Shing, Tracy L. Nero, Tracy L. Nero, Craig J. Morton, Craig J. Morton, Craig J. Morton, Michael W. Parker, Michael W. Parker, Michael W. Parker, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen   +24 more
doaj   +1 more source

Incidence and Impact of Routine Inflammatory Parameters on Outcome after Transcatheter Aortic Valve Replacement

Journal of Interventional Cardiology, 2021
Background. Previous research reported adverse clinical outcomes in association with systemic inflammation (SI) after transcatheter aortic valve replacement (TAVR).
Polykarpos C Patsalis, Assem Aweimer, Henrik Scharkowski, Dritan Useini, Peter Lukas Haldenwang, Justus Thomas Strauch, Ali Canbay, Andreas Mügge, Antonios Katsounas   +8 more
doaj   +1 more source

A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein

, 2023
C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally relatively inert ...
Baratchi, S, Wang, X, Horner, VK, Peter, K, Parker, MW, Kiefer, J, Krippner, G, Kammerer, B, Nero, TL, Zeller, J, Bogner, B, Braig, D, Cheung Tung Shing, KS, Kather, MG, Fricke, M, Woollard, KJ, Morton, CJ, Danish, H, Sharma, P, Kreuzaler, S, McFadyen, JD, Eisenhardt, SU, Pietersz, G   +22 more
core   +1 more source

The intermediate formed on hydrophobic surfaces binds the solution-phase pCRP in a calcium-dependent manner with high affinity.

, 2018
(A) Binding of biotin-labeled pCRP to pCRP (5 μg/ml) immobilized in TBS-Ca (pH 7.4) overnight at 4°C. Biotin-labeled pCRP bound immobilized pCRP in a calcium-dependent fashion. **p d for the homo-complex formation of pCRP (~1.5 nM vs. ~20 μM).
Jian-Min Lv (5324774), Ming-Yu Wang (598434)   +1 more
core   +1 more source

Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?

Frontiers in Immunology, 2023
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Anne Helene Køstner, Anne Helene Køstner, Anniken Jørlo Fuglestad, Anniken Jørlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten, Christian Kersten   +14 more
doaj   +1 more source