Results 51 to 60 of about 2,499 (154)
Mediators of Inflammation, Volume 2026, Issue 1, 2026.The relationship between the C‐reactive protein (CRP)‐albumin‐lymphocyte (CALLY) index and disease activity of rheumatoid arthritis (RA) has not been explored at present. This study included 1058 RA patients and used a multiple linear regression model to evaluate the association between the CALLY index and 28 joint disease activity scores (DAS28) and ...
Lina Leng +6 more
wiley +1 more source
Docking simulation predicts that mCRP binds to integrin αvβ3 but pCRP does not.
, 2014 a) The headpiece of integrin αvβ3 (PDB code 1LG5) was used as a target. The docking model predicts that mCRP (red) binds to the RGD-binding site of the integrin αvβ3 headpiece (green and blue). Amino acid residues involved in αvβ3-mCRP interaction are in
Yoko K. Takada (365353) +3 more
core +1 more source
Extracellular vesicles are associated with C-reactive protein in sepsis
Scientific Reports, 2021 There is increasing evidence that C-reactive protein (CRP) can mediate inflammatory reactions following the transformation of functionally inert pentameric CRP (pCRP) into its structural isoform pCRP* and into monomeric CRP (mCRP).
Birgit Fendl +8 more
doaj +1 more source
Journal of Geophysical Research: Atmospheres, Volume 130, Issue 19, 16 October 2025.Abstract It is still challenging to reproduce marine boundary layer (MBL) clouds well in large‐scale models despite their importance to the Earth's radiation budget and hydrological cycle. This study evaluates representation of the MBL and clouds in the Energy Exascale Earth System Model (E3SM) version 2. This study compares the E3SM simulation results
Kyoung Ock Choi +8 more
wiley +1 more source
mCRP specifically binds to αvβ3, but pCRP less efficiently binds to the integrin.
, 2014 Wells of 96 well microtiter plate were coated with mCRP or pCRP and remaining protein-binding sites were blocked with BSA. a) ELISA-type integrin binding assay.
Yoko K. Takada (365353) +3 more
core +1 more source
Frontiers in ImmunologyC-reactive protein (CRP) is an acute-phase protein produced by the liver in response to infection and during chronic inflammatory disorders. Systemic inflammation is a major driver of cirrhosis progression from the compensated to the decompensated stage.
Ning Gao +15 more
doaj +1 more source
Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes
Mediators of Inflammation, 2015 C-reactive protein (CRP) is a pentraxin that has long been employed as a marker of inflammation in clinical practice. Recent findings brought up the idea of CRP to be not only a systemic marker but also a mediator of inflammation.
J. R. Thiele +5 more
doaj +1 more source
RelA Inhibits Embryonic Myogenesis by Coordinately Regulating a Novel Distal Enhancer of Myogenin
Advanced Science, Volume 12, Issue 38, October 13, 2025.Maternal obesity (MO) accounts for more than 40% of pregnancies in the United States, induces inflammation, and impairs embryonic myogenesis, known to program muscle dysfunction in offspring. Inflammation enhances the binding of RelA to a novel distal enhancer located 4 kb upstream of myogenin promoter to inhibit embryonic myogenesis, which is ...
Md Nazmul Hossain +9 more
wiley +1 more source
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions
EMBO Molecular Medicine, 2022 C‐reactive protein (CRP) is a marker of acute inflammation and modulator of host defense against infections. CRP exists in conformationally distinct forms that exhibit opposing biological functions and could amplify tissue damage.
János G Filep
doaj +1 more source
The Role of Anti-mCRP Autoantibodies in Lupus Nephritis
Kidney Diseases, 2023 Background: Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis.
Mo Yuan, Ying Tan, Ming-hui Zhao
doaj +1 more source