Results 51 to 60 of about 2,447 (150)

Threshold Effect of C‐Reactive Protein‐Albumin‐Lymphocyte (CALLY) Index on Disease Activity in Rheumatoid Arthritis: Unveiling a Nonlinear Association

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
The relationship between the C‐reactive protein (CRP)‐albumin‐lymphocyte (CALLY) index and disease activity of rheumatoid arthritis (RA) has not been explored at present. This study included 1058 RA patients and used a multiple linear regression model to evaluate the association between the CALLY index and 28 joint disease activity scores (DAS28) and ...
Lina Leng, Quanyi Tang, Ying Li, Jinfeng Zhang, Yaorong Han, Xiaoli Li, Fumio Tsuji   +6 more
wiley   +1 more source

mCRP, and less efficiently pCRP, specifically bind to α4β1.

, 2014
a). Adhesion of α4-CHO cells to CRP isoforms. Wells of 96 well microtiter plate were coated with mCRP or pCRP and remaining protein-binding sites were blocked with BSA.
Yoko K. Takada (365353), Yoshikazu Takada (32897), Yoshihiro Izumiya (449433), Masaaki Fujita (365351)   +3 more
core   +1 more source

Evaluation of Marine Boundary Layer Clouds Over the Northeast Pacific During the CSET Campaign in E3SM Version 2

Journal of Geophysical Research: Atmospheres, Volume 130, Issue 19, 16 October 2025.
Abstract It is still challenging to reproduce marine boundary layer (MBL) clouds well in large‐scale models despite their importance to the Earth's radiation budget and hydrological cycle. This study evaluates representation of the MBL and clouds in the Energy Exascale Earth System Model (E3SM) version 2. This study compares the E3SM simulation results
Kyoung Ock Choi, Philip J. Rasch, Robert Wood, Sarah J. Doherty, Hui Wan, Hailong Wang, Shixuan Zhang, Kai Zhang, Mingxuan Wu   +8 more
wiley   +1 more source

Monomeric C-reactive protein is associated with severity and prognosis of decompensated hepatitis B cirrhosis

Frontiers in Immunology
C-reactive protein (CRP) is an acute-phase protein produced by the liver in response to infection and during chronic inflammatory disorders. Systemic inflammation is a major driver of cirrhosis progression from the compensated to the decompensated stage.
Ning Gao, Ping Yuan, Zhao-Ming Tang, Zhao-Ming Tang, Jia-Geng Lei, Ze-Rui Yang, Ze-Rui Yang, Mustafa Ahmed, Mustafa Ahmed, Zhen-Yu Yao, Dan Liang, Dan Liang, Yi Wu, Yi Wu, Hai-Yun Li, Hai-Yun Li   +15 more
doaj   +1 more source

Extracellular vesicles are associated with C-reactive protein in sepsis

Scientific Reports, 2021
There is increasing evidence that C-reactive protein (CRP) can mediate inflammatory reactions following the transformation of functionally inert pentameric CRP (pCRP) into its structural isoform pCRP* and into monomeric CRP (mCRP).
Birgit Fendl, René Weiss, Tanja Eichhorn, Ingrid Linsberger, Taras Afonyushkin, Florian Puhm, Christoph J. Binder, Michael B. Fischer, Viktoria Weber   +8 more
doaj   +1 more source

RelA Inhibits Embryonic Myogenesis by Coordinately Regulating a Novel Distal Enhancer of Myogenin

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Maternal obesity (MO) accounts for more than 40% of pregnancies in the United States, induces inflammation, and impairs embryonic myogenesis, known to program muscle dysfunction in offspring. Inflammation enhances the binding of RelA to a novel distal enhancer located 4 kb upstream of myogenin promoter to inhibit embryonic myogenesis, which is ...
Md Nazmul Hossain, Yao Gao, Sharmeen Islam, Li‐Wei Chen, Xinrui Li, Zhongyun Kou, Nathan C Law, Jeanene Marie de Avila, Mei‐Jun Zhu, Min Du   +9 more
wiley   +1 more source

Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes

Mediators of Inflammation, 2015
C-reactive protein (CRP) is a pentraxin that has long been employed as a marker of inflammation in clinical practice. Recent findings brought up the idea of CRP to be not only a systemic marker but also a mediator of inflammation.
J. R. Thiele, J. Zeller, H. Bannasch, G. B. Stark, K. Peter, S. U. Eisenhardt   +5 more
doaj   +1 more source

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence‐Associated Secretory Phenotype

Aging Cell, Volume 24, Issue 10, October 2025.
The chromatin accessibility landscape of senescent cells is remodeled, with a set of activated transcription factors physically binding to the enhancers and promoters of senescence‐associated genes, including those encoding SASP factors. Events such as epigenomic reprogramming and KDM4‐mediated histone demethylation (H3K9/H3K36) enable SASP expression ...
Boyi Zhang, Qilai Long, Shanshan Wu, Qixia Xu, Shuling Song, Liu Han, Min Qian, Xiaohui Ren, Hanxin Liu, Jing Jiang, Jianming Guo, Xiaoling Zhang, Xing Chang, Qiang Fu, Eric W.‐F. Lam, Judith Campisi, James L. Kirkland, Yu Sun   +17 more
wiley   +1 more source

Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation. [PDF]

Circ Res
BACKGROUND: CRP (C-reactive protein) is a prototypical acute phase reactant. Upon dissociation of the pentameric isoform (pCRP [pentameric CRP]) into its monomeric subunits (mCRP [monomeric CRP]), it exhibits prothrombotic and proinflammatory activity ...
Zeller J, Loseff-Silver J, Khoshmanesh K, Baratchi S, Lai A, Nero TL, Roy A, Watson A, Dayawansa N, Sharma P, Barbaro-Wahl A, Chen YC, Moon M, Vidallon MLP, Huang A, Thome J, Cheung Tung Shing KS, Harvie D, Bongiovanni MN, Braig D, Morton CJ, Htun NM, Stub D, Walton A, Horowitz J, Wang X, Pietersz G, Parker MW, Eisenhardt SU, McFadyen JD, Peter K.   +30 more
europepmc   +3 more sources

Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions

EMBO Molecular Medicine, 2022
C‐reactive protein (CRP) is a marker of acute inflammation and modulator of host defense against infections. CRP exists in conformationally distinct forms that exhibit opposing biological functions and could amplify tissue damage.
János G Filep
doaj   +1 more source