Results 71 to 80 of about 2,447 (150)

Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens

open access: yesThe Journal of Pathology, Volume 265, Issue 2, Page 146-157, February 2025.
Abstract The presence, location, and extent of prostate cancer is assessed by pathologists using H&E‐stained tissue slides. Machine learning approaches can accomplish these tasks for both biopsies and radical prostatectomies. Deep learning approaches using convolutional neural networks (CNNs) have been shown to identify cancer in pathologic slides ...
Brennan T Flannery   +18 more
wiley   +1 more source

pSTAT3 Expression is Increased in Advanced Prostate Cancer in Post‐Initiation of Androgen Deprivation Therapy

open access: yesThe Prostate, Volume 85, Issue 3, Page 252-264, February 2025.
ABSTRACT Background The transcription factor Signal Transducer and Activator of Transcription 3 (STAT3) plays a role in carcinogenesis and is involved in processes, such as proliferation, differentiation, drug resistance and immunosuppression. STAT3 can be activated by phosphorylation of tyrosine at position 705 (pSTAT3Tyr705) or serine at 727 ...
Piotr Bialas   +14 more
wiley   +1 more source

Nonparaxial Propagation Properties of Specially Correlated Radially Polarized Beams in Free Space

open access: yesApplied Sciences, 2019
A specially correlated radially polarized (SCRP) beam with unusual physical properties on propagation in the paraxial regime was introduced and generated recently.
Lina Guo   +6 more
doaj   +1 more source

THE PROPERTIES OF LSM-ESTIMATOR OF CORRELATION FUNCTION OF BIPERIODICALLY CORRELATED RANDOM PROCESSES

open access: yesМіжнародний науково-технічний журнал "Проблеми керування та інформатики", 2020
Recurrence and stochasticity are the features of a lot of oscillation processes which occur in the different fields of science and techniques. Nowadays the models in the form of periodically correlated random processes are successfully used for the ...
І.М. Яворський   +3 more
doaj   +1 more source

CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor

open access: yesThe FASEB Journal, Volume 39, Issue 2, 31 January 2025.
Prostate cancer demonstrates significantly elevated levels of CRM1 expression. Inhibition of CRM1 by Selinexor leads to a decrease in androgen receptor (AR) transcript and protein. We demonstrate that CRM1 regulates the nuclear export of HSP90, a key chaperone that regulates the stability of AR protein.
Rajendra Kumar   +14 more
wiley   +1 more source

Evaluation of Yellow Mealworm (Tenebrio molitor) Larvae Meal as a Carbon Source in Biofloc System for Dwarf Crayfish (Cambarellus montezumae) Culture

open access: yesAquaculture Nutrition, Volume 2025, Issue 1, 2025.
The aim of this study was to evaluate the use of Tenebrio molitor larvae meal as a carbon source in a biofloc system (BFT) to optimize the culture of C. montezumae. A trial was conducted for 24 weeks, 500 T. molitor larvae were reared with wheat bran as substrate, and hydration once a week; at the end, 9000 T.
Reyna Perla Paredes-Chávez   +6 more
wiley   +1 more source

Agromorphological Characterization of Passiflora edulis f. flavicarpa Degener in Miraflores, Colombia

open access: yesInternational Journal of Agronomy, Volume 2025, Issue 1, 2025.
Passiflora edulis f. flavicarpa Degener is a species of economic importance belonging to the genus Passiflora, native to Brazil. It has some alkaloids, flavonoids, carotenoids, minerals, vitamins A, C, and D with anxiolytic, antihypertensive, sedative, and analgesic properties.
Daniel Alberto Muñoz-Fonseca   +3 more
wiley   +1 more source

Monomeric CRP is prevalent in the blood of patients with rheumatoid arthritis and correlates with clinically relevant markers

open access: yesFrontiers in Immunology
IntroductionElevated C-reactive protein (CRP) is a hallmark of rheumatoid arthritis (RA) flares. CRP exists as pentameric (pCRP) and monomeric (mCRP) isoforms with distinct functions, with pCRP generally pro-inflammatory and mCRP more immunomodulatory ...
Alexia Correia Ferreira   +10 more
doaj   +1 more source

A novel non-catalytic function of PA2803-encoded PcrP contributes to polymyxin B resistance in P. aeruginosa and redefines the functional role of the PA2803 subfamily.

open access: yes
The opportunistic human pathogen Pseudomonas aeruginosa (Pa), a leading cause of severe infections, becomes increasingly resistant to antibiotics, including the last resort antibiotic, polymyxin-B (PMB). Previous studies have shown that calcium (Ca 2+ ) at the levels encountered during infections ...
Tarosha Salpadoru   +12 more
openaire   +2 more sources

Immunodetection of pentamer and modified C-reactive protein using surface plasmon resonance biosensing

open access: yes, 2012
[[abstract]]In clinical practices, the examination of pentamer C-reactive protein (pCRP) is commonly used as a prognostic indicator of the risk of a patient developing cardiovascular disease (CVD). Structural modification of pCRP produces a modified CRP (
胡文品;Hu, Wen-Pin
core  

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