Results 61 to 70 of about 2,499 (154)
Aging Cell, Volume 24, Issue 10, October 2025.The chromatin accessibility landscape of senescent cells is remodeled, with a set of activated transcription factors physically binding to the enhancers and promoters of senescence‐associated genes, including those encoding SASP factors. Events such as epigenomic reprogramming and KDM4‐mediated histone demethylation (H3K9/H3K36) enable SASP expression ...
Boyi Zhang +17 more
wiley +1 more source
Western blot of dialyzed CRP and treated CRP with urea and EDTA.
, 2019 The dialyzed CRP appeared at much higher sizes than the treated CRP did, suggesting pentameric CRP (pCRP) and monomeric CRP (mCRP), respectively. Western blotting showed that the mCRP was detected with the anti-CRP antibody (ab32412).
So Ra Kim (458940) +7 more
core +1 more source
Biochemically prepared C-reactive protein conformational states differentially affect C1q binding
BBA Advances, 2022 C-reactive protein (CRP) is commonly measured as an inflammatory marker in patient studies for coronary heart disease, autoimmune disease and recent acute infections.
Carrie L. Moon +4 more
doaj +1 more source
Epilepsia, Volume 66, Issue 8, Page 3048-3063, August 2025.Abstract Objective KCNB1 encodes an α‐subunit of the delayed‐rectifier voltage‐dependent potassium channel Kv2.1. De novo pathogenic variants of KCNB1 have been linked to developmental and epileptic encephalopathies (DEEs), diagnosed in early childhood and sharing limited treatment options.
Lauralee Robichon +7 more
wiley +1 more source
Defeating lethal cancer: Interrupting the ecologic and evolutionary basis of death from malignancy
CA: A Cancer Journal for Clinicians, Volume 75, Issue 3, Page 183-202, May/June 2025.Abstract Despite the advances in cancer prevention, early detection, and treatments, all of which have led to improved cancer survival, globally, there is an increased incidence in cancer‐related deaths. Although each patient and each tumor is wholly unique, the tipping point to incurable disease is common across all patients: the dual capacity for ...
Kenneth J. Pienta +2 more
wiley +1 more source
, 2022 Additional file 2: Supplementary Figure 2. Comparisons of pentameric C-reactive protein (pCRP) (A–C), monomeric (m)CRP (D–F), and mCRP/pCRP ratio (G–I) demonstrated between normal vs.
Jesper Karlsson (12863105) +5 more
core +1 more source
Advanced Science, Volume 12, Issue 20, May 29, 2025.As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang +10 more
wiley +1 more source
Cancer Medicine, Volume 14, Issue 10, May 2025.ABSTRACT Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis.
Kayla Bastian +28 more
wiley +1 more source
Health Science Reports, Volume 8, Issue 5, May 2025.ABSTRACT Introduction C‐reactive protein (CRP) is an inflammatory biomarker, implicated in the pathogenesis of atherosclerotic lesion formation, plaque rupture, and coronary thrombosis. The relationship between preprocedural CRP levels and subsequent development of in‐stent restenosis (ISR) after percutaneous coronary intervention (PCI) however remains
Himanshu Rai +6 more
wiley +1 more source
, 2022 Additional file 1: Supplementary Figure 1. Comparisons of pentameric C-reactive protein (pCRP) (A–D), monomeric (m)CRP (E–H), and mCRP/pCRP ratio (I–L) in 160 patients with systemic lupus erythematosus with lupus nephritis vs.
Jesper Karlsson (12863105) +5 more
core +1 more source