Results 61 to 70 of about 2,447 (150)

The Role of Anti-mCRP Autoantibodies in Lupus Nephritis

open access: yesKidney Diseases, 2023
Background: Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis.
Mo Yuan, Ying Tan, Ming-hui Zhao
doaj   +1 more source

kcnb1 loss of function in zebrafish causes neurodevelopmental and epileptic disorders associated with γ‐aminobutyric acid dysregulation

open access: yesEpilepsia, Volume 66, Issue 8, Page 3048-3063, August 2025.
Abstract Objective KCNB1 encodes an α‐subunit of the delayed‐rectifier voltage‐dependent potassium channel Kv2.1. De novo pathogenic variants of KCNB1 have been linked to developmental and epileptic encephalopathies (DEEs), diagnosed in early childhood and sharing limited treatment options.
Lauralee Robichon   +7 more
wiley   +1 more source

Biochemically prepared C-reactive protein conformational states differentially affect C1q binding

open access: yesBBA Advances, 2022
C-reactive protein (CRP) is commonly measured as an inflammatory marker in patient studies for coronary heart disease, autoimmune disease and recent acute infections.
Carrie L. Moon   +4 more
doaj   +1 more source

Defeating lethal cancer: Interrupting the ecologic and evolutionary basis of death from malignancy

open access: yesCA: A Cancer Journal for Clinicians, Volume 75, Issue 3, Page 183-202, May/June 2025.
Abstract Despite the advances in cancer prevention, early detection, and treatments, all of which have led to improved cancer survival, globally, there is an increased incidence in cancer‐related deaths. Although each patient and each tumor is wholly unique, the tipping point to incurable disease is common across all patients: the dual capacity for ...
Kenneth J. Pienta   +2 more
wiley   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

open access: yesAdvanced Science, Volume 12, Issue 20, May 29, 2025.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang   +10 more
wiley   +1 more source

Coupling Efficiency of a Partially Coherent Radially Polarized Vortex Beam into a Single-Mode Fiber

open access: yesApplied Sciences, 2018
We study the problem of coupling partially coherent radially polarized (PCRP) vortex beams into a single-mode optical fiber. Using the well-known concept of the cross-spectral density (CSD) matrix, we derive a general expression for the coupling ...
Xinlei Zhu   +4 more
doaj   +1 more source

FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors

open access: yesCancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis.
Kayla Bastian   +28 more
wiley   +1 more source

Pre‐Percutaneous Coronary Intervention C‐Reactive Protein Levels and In‐Stent Restenosis: A Systematic Review and Meta‐Analysis

open access: yesHealth Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Introduction C‐reactive protein (CRP) is an inflammatory biomarker, implicated in the pathogenesis of atherosclerotic lesion formation, plaque rupture, and coronary thrombosis. The relationship between preprocedural CRP levels and subsequent development of in‐stent restenosis (ISR) after percutaneous coronary intervention (PCI) however remains
Himanshu Rai   +6 more
wiley   +1 more source

Stable and discriminating OCT‐derived radiomics features for predicting anti‐VEGF treatment response in diabetic macular edema

open access: yesMedical Physics, Volume 52, Issue 5, Page 2762-2772, May 2025.
Abstract Background Radiomics‐based characterization of fluid and retinal tissue compartments of spectral‐domain optical coherence tomography (SD‐OCT) scans has shown promise to predict anti‐VEGF therapy treatment response in diabetic macular edema (DME). Radiomics features are sensitive to different image acquisition parameters of OCT scanners such as
Sudeshna Sil Kar   +4 more
wiley   +1 more source

The surface-induced intermediate exhibited enhanced complement interaction capacity.

open access: yes, 2018
5 μg/ml pCRP or mCRP was immobilized in TBS-Ca or TBS-EDTA (pH 7.4) at 4°C overnight. Alternatively, 50 μg/ml pCRP was bound to immobilized PC-BSA overnight at 4°C in TBS-Ca (pH 7.4).
Jian-Min Lv (5324774)   +1 more
core   +1 more source

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