Results 11 to 20 of about 2,499 (154)

pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics [PDF]

Frontiers in Immunology, 2018
Circulating C-reactive protein (CRP) is a key acute-phase protein and one of the main clinical biomarkers for inflammation and infection. CRP is an important upstream mediator of inflammation and is associated with the onset of a number of important ...
Mario Di Napoli, Wen-Hui Fang, Lina Badimon   +2 more
exaly   +14 more sources

A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation [PDF]

BMC Biology
Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune ...
Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang   +17 more
doaj   +3 more sources

A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein

EMBO Molecular Medicine, 2022
C‐reactive protein (CRP) is an early‐stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally relatively inert ...
Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balázs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt   +22 more
doaj   +2 more sources

Yet Another Simple Proof of the PCRP Theorem [PDF]

The Probabilistically Checkable Reconfiguration Proof (PCRP) theorem, proven by Hirahara and Ohsaka (STOC 2024) [Hirahara and Ohsaka, 2024] and Karthik C. S. and Manurangsi [{Karthik {C.
Ohsaka, Naoto
core   +4 more sources

In vitro generation and bioactivity evaluation of C-reactive protein intermediate. [PDF]

PLoS ONE, 2018
The conformational conversion of pentameric C-reactive protein (pCRP) to monomeric CRP (mCRP) has been shown to play important roles in the action of CRP in inflammation regulation.
Jian-Min Lv, Ming-Yu Wang
doaj   +2 more sources

Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

Journal of Inflammation Research, 2021
Revathy Munuswamy,1,* Jana De Brandt,2,* Chris Burtin,2 Wim Derave,3 Joseph Aumann,4 Martijn A Spruit,5,6,* Luc Michiels1,* 1Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium;
Munuswamy R, De Brandt J, Burtin C, Derave W, Aumann J, Spruit MA, Michiels L   +6 more
doaj   +2 more sources

Factors Associated with Referral of Patients with Advanced Cancer Utilizing a Palliative Care Referral Protocol [PDF]

Revista Brasileira de Cancerologia
Introduction: Numerous barriers hinder timely referral to palliative care (PC) leading to inadequate symptom management and diminished quality of life.
Bianca Sakamoto Ribeiro Paiva, Gabriela Chioli Boer, Bruna Minto Lourenço, Welinton Yoshio Hirai, Carlos Eduardo Paiva   +4 more
doaj   +2 more sources

Role of EP4 factor in paediatric type 1 diabetes mellitus: a comprehensive review focusing on the honeymoon period

Pediatric Endocrinology, Diabetes and Metabolism
The partial clinical recovery phase (PCRP), or “honeymoon period”, is a temporary and partial restoration of b-cell function in patients with type 1 diabetes mellitus (T1DM), in which the immune system attacks and destroys insulin-producing b-cells.
Forough Taheri, Nekoo Panahi, Aida Vahidi, Mojgan Asadi, Mahsa M. Amoli, Naieme Goharifar   +5 more
doaj   +2 more sources

CRP Is Transported by Monocytes and Monocyte-Derived Exosomes in the Blood of Patients with Coronary Artery Disease

Biomedicines, 2020
The objective of this work was to study the ability of blood cells and their microparticles to transport monomeric and pentameric forms of C-reactive protein (mCRP and pCRP) in the blood of patients with coronary artery disease (CAD).
Ivan Melnikov, Sergey Kozlov, Olga Saburova, Ekaterina Zubkova, Olga Guseva, Sergey Domogatsky, Tatiana Arefieva, Natalia Radyukhina, Maria Zvereva, Yuliya Avtaeva, Lyudmila Buryachkovskaya, Zufar Gabbasov   +11 more
doaj   +2 more sources

The Effects of a Mindfulness-Based Intervention on Depression and Anxiety in the Long-COVID Population [PDF]

Journal of Patient-Centered Research and Reviews
Long-COVID is a complicated, post-viral syndrome involving multiple body systems and can present with neuropsychiatric symptoms. Little has been reported about the neuropsychiatric symptoms of long-COVID, and validated treatments do not yet exist.
Rachel Welbel, Elizabeth Rutha, Jeffrey Ording, Douglas Wang, Jana Hirschtick   +4 more
doaj   +2 more sources