Results 21 to 30 of about 2,447 (150)

Role of EP4 factor in paediatric type 1 diabetes mellitus: a comprehensive review focusing on the honeymoon period

open access: yesPediatric Endocrinology, Diabetes and Metabolism
The partial clinical recovery phase (PCRP), or “honeymoon period”, is a temporary and partial restoration of b-cell function in patients with type 1 diabetes mellitus (T1DM), in which the immune system attacks and destroys insulin-producing b-cells.
Forough Taheri   +5 more
doaj   +2 more sources

Mood Disorder Begins in the Mouth: Periodontitis Mediates Anxiety-Like Behaviors. [PDF]

open access: yesAdv Sci (Weinh)
ABSTRACT The previous study elucidated that the C‐reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis‐associated anxiety‐like behaviors in rats. This molecular crosstalk along the periodontal‐hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several
Chen Z, Li X.
europepmc   +2 more sources

Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis [PDF]

open access: yes, 2019
The research described here considers molecular variations of the acute phase response protein, C reactive protein (CRP), and the presence of CRP and anti CRP autoantibodies in rheumatoid arthritis (RA) patient serum.Monomeric CRP (mCRP) was generated in
Moran, Jennifer Ann
core   +7 more sources

A ChIP-exo screen of 887 PCRP transcription factor antibodies in human cells [PDF]

open access: yes, 2020
Abstract Antibodies offer a powerful means to interrogate specific proteins in a complex milieu. However, antibody availability and reliability are problematic and epitope tagging can be impractical in many cases. In an effort to improve this situation, the Protein Capture Reagents Program (PCRP) generated over a ...
William K. M. Lai   +24 more
openaire   +1 more source

A biofunctional review of C-reactive protein (CRP) as a mediator of inflammatory and immune responses: differentiating pentameric and modified CRP isoform effects

open access: yesFrontiers in Immunology, 2023
C-reactive protein (CRP) is an acute phase, predominantly hepatically synthesized protein, secreted in response to cytokine signaling at sites of tissue injury or infection with the physiological function of acute pro-inflammatory response. Historically,
Margaret E. Olson   +8 more
doaj   +1 more source

STENCIL application in PCRP.

open access: yes, 2022
Application of STENCIL in the PCRP was an NIH-initiated project to screen 800 antibodies in ChIP-exo. NIH project requirements included providing the generated data in a community-accessible manner.
Prashant K. Kuntala (12066243)   +5 more
core   +1 more source

C-Reactive Protein and Cancer: Interpreting the Differential Bioactivities of Its Pentameric and Monomeric, Modified Isoforms

open access: yesFrontiers in Immunology, 2021
C-reactive protein (CRP) was first recognized in the 1940s as a protein that appeared in blood during acute episodes of infectious disease. Its presence and pharmacodynamics were found in essentially all diseases that involved tissue damage and ...
Lawrence A. Potempa   +3 more
doaj   +1 more source

A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein

open access: yesEMBO Molecular Medicine, 2022
C‐reactive protein (CRP) is an early‐stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally relatively inert ...
Johannes Zeller   +22 more
doaj   +1 more source

Pentameric C-reactive protein is a better prognostic biomarker and remains elevated for longer than monomeric CRP in hospitalized patients with COVID-19

open access: yesFrontiers in Immunology, 2023
The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome ...
Francis R. Hopkins   +16 more
doaj   +1 more source

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