Results 151 to 160 of about 163,143 (174)

Bifunctional glycolipids targeting TLR4·MD-2 and short pentraxins. [PDF]

RSC Chem Biol
Zucchetta D, Nuschy L, Gumpelmair S, Steinberger P, Wilson I, Heine H, Zamyatina A.   +6 more
europepmc   +1 more source

Enhancing gemcitabine uptake by promoting dimerization of ENT1 transporter improves response rates of patients with sarcoma. [PDF]

J Clin Invest
Ganju A, Rao S, Dickson MA, Lefkowitz RA, Thompson C, Cheng J, Manova K, Haimovitz-Friedman A, Schwartz G, Zhang Z, Fuks Z, Tap WD, Kolesnick R.   +12 more
europepmc   +1 more source

Expression characteristics of C-reactive protein in autoimmune diseases and their complications. [PDF]

Front Immunol
Yang Q, Luo Y, Luo Y, Zeng L, Sun L.
europepmc   +1 more source

Reduced serum levels of autoantibodies against monomeric C-reactive protein (CRP) in patients with acute coronary syndrome [PDF]

Clinica Chimica Acta, 2009
Inflammation is pivotal in atherosclerosis. Minor C-reactive protein (CRP) response reflects low-grade vascular inflammation and the high-sensitivity CRP test with levels > or = 3.0 mg/l predicts coronary vascular events and survival in angina pectoris as well as in healthy subjects. We and others recently reported autoantibodies against monomeric CRP (
Lena Jonasson, Lennart Nilsson, Jonas Wetterö   +2 more
exaly   +6 more sources

Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP

Journal of Autoimmunity, 2023
The pentraxin C-reactive protein (CRP) is a pentameric protein now known to be able to undergo dissociation into a monomeric, modified isoform, referred to as mCRP. In carefully assessing the bioactivities of each isoform, mCRP has strong pro-inflammatory activities while pCRP has mild anti-inflammatory activities. Systemic lupus erythematosus (SLE) is
Rafael Fernandez-botran, Jonas Wetterö, Fariborz Mobarrez   +2 more
exaly   +6 more sources

C-reactive protein (CRP) aptamer binds to monomeric but not pentameric form of CRP [PDF]

Analytical and Bioanalytical Chemistry, 2011
Native C-reactive protein (CRP) is composed of five identical subunits arranged in a pentameric structure (pCRP). Binding of pCRP to damaged cell membranes produces a second isoform, modified CRP, which has similar antigenicity to isolated monomeric subunits of CRP (mCRP).
Joshua C Black, Min S Wang, Scott M. Reed   +2 more
exaly   +3 more sources

Association of monomeric C-Reactive Protein (m-CRP) with hypothalamic neurons after CRP hippo-campal administration in a model of dementia.

European Review for Medical and Pharmacological Sciences, 2022
The ensuing ischemia due to the disruption of blood supply to the brain is one of the most common causes of stroke. Evidence suggests a clear association of the ischemic injury with vascular dementia and Alzheimer's disease (AD). In response to the brain ischemia, a cascade reaction starts leading to neuronal damage due to oxidative stress and other ...
Al-Baradie, RS, Abdel-Hadi, AM, Ahmad, F, Alsagaby, SA, Slevin, M, Alturaiki, W, Madkhali, Y, Aljarallah, BM, Alqahtani, M, Miraj, M, Ahmad, I, Albaradie, N, Albaradie, R   +12 more
exaly   +4 more sources

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Increased monomeric CRP levels in acute myocardial infarction: A possible new and specific biomarker for diagnosis and severity assessment of disease

Atherosclerosis, 2015
Monomeric CRP (mCRP) plays an important role in the process of atherosclerotic plaque rupture. Recently, it has been reported that mCRP was associated with acute myocardial infarction (AMI).The aim of this study was to examine whether mCRP is increased in AMI patients and to investigate the possibility of using circulating mCRP as a biomarker for AMI ...
Junhong Wang
exaly   +3 more sources

Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H [PDF]

Cell Death and Differentiation, 2009
Complement forms the first defense line of innate immunity and has an important role in the non-inflammatory clearance of apoptotic and necrotic cells. Factor H is one essential complement inhibitor that binds to the acute phase reactant C-reactive protein (CRP).
Mihály Józsi, Peter F Zipfel
exaly   +3 more sources