Results 71 to 80 of about 272,971 (193)

Biomarkers of inflammatory arthritis and proteomics [PDF]

, 2013
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FitzGerald, Oliver, R., Stephen, S., Opeyemi, Staunton, Lisa   +3 more
core   +3 more sources

Adaptive laboratory evolution of a genome-reduced Escherichia coli. [PDF]

, 2019
Synthetic biology aims to design and construct bacterial genomes harboring the minimum number of genes required for self-replicable life. However, the genome-reduced bacteria often show impaired growth under laboratory conditions that cannot be ...
Cho, Byung-Kwan, Cho, Suhyung, Choe, Donghui, Hwang, Soonkyu, Kim, Sun Chang, Lee, Jun Hyoung, Palsson, Bernhard, Sung, Bong Hyun, Yoo, Minseob   +8 more
core   +2 more sources

The Role of Anti-mCRP Autoantibodies in Lupus Nephritis

Kidney Diseases, 2023
Background: Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis.
Mo Yuan, Ying Tan, Ming-hui Zhao
doaj   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics

Frontiers in Immunology, 2018
Circulating C-reactive protein (CRP) is a key acute-phase protein and one of the main clinical biomarkers for inflammation and infection. CRP is an important upstream mediator of inflammation and is associated with the onset of a number of important ...
Vittorio Caprio, Lina Badimon, Mario Di Napoli, Wen-Hui Fang, Glenn R. Ferris, Baoqiang Guo, Baoqiang Guo, Rocco S. Iemma, Donghui Liu, Donghui Liu, Yasmin Zeinolabediny, Yasmin Zeinolabediny, Mark Slevin, Mark Slevin, Mark Slevin, Mark Slevin   +15 more
doaj   +1 more source

A meta-analysis investigating the relationship between inflammation in autoimmune disease, elevated CRP, and the risk of dementia

Frontiers in Immunology, 2023
Alzheimer’s Disease (AD) represents the most common type of dementia and is becoming a steadily increasing challenge for health systems globally. Inflammation is developing as the main focus of research into Alzheimer’s disease and has been demonstrated ...
Joseph Cooper, Ylenia Pastorello, Mark Slevin, Mark Slevin   +3 more
doaj   +1 more source

Peptide Receptor‐Functionalized AuNP‐Embedded Zwitterionic Biopolymeric Nanohydrogel for Electrochemical Sclerostin Sensing

Advanced Science, EarlyView.
We report an electrochemical biosensor that employs biopanning‐derived affinity peptides as selective receptors on a multifunctional chitosan–zwitterionic–gold nanoparticle (CS–ZI–AuNPs) nanohydrogel interface. The CS–ZI–AuNPs nanohydrogel exhibits antifouling properties, abundant sites for stable peptide immobilization, and efficient electrochemical ...
Hyo Jeong Yang, Jae Hwan Shin, Mingi Jo, Changyeon Lee, Hyunmin Yi, Al‐Montaser Bellah H. Ali, Jong Pil Park   +6 more
wiley   +1 more source

Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation

Frontiers in Immunology, 2018
C-reactive protein (CRP) is an established marker of rheumatoid arthritis (RA) but with ill-defined actions in the pathogenesis. Here, we show that CRP regulates the differentiation of osteoclasts, a central mediator of joint inflammation and bone ...
Zhe-Kun Jia, Hai-Yun Li, Yu-Lin Liang, Lawrence Albert Potempa, Shang-Rong Ji, Yi Wu, Yi Wu   +6 more
doaj   +1 more source

Influence of severity of illness on neutrophil gelatinase-associated lipocalin performance as a marker of acute kidney injury : a prospective cohort study of patients with sepsis [PDF]

, 2015
Background: The role of neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic marker for acute kidney injury (AKI) in sepsis is still debated.
Dhondt, Annemieke, Glorieux, Griet, Hoste, Eric, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond, Vanmassenhove, Jill   +6 more
core   +2 more sources

Peripheral vascular function, including endothelium‐dependent measures, and dementia risk: The Framingham Heart Study

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION The relationship between peripheral vascular health, including endothelia, cognitive decline, and Alzheimer's disease (AD) dementia risk is unclear. METHODS In this study, 2844 dementia‐free Framingham Offspring participants (mean age 60.6 years, 53.2% women) had baseline brachial artery flow‐mediated dilation (FMD%) and reactive ...
Qiushan Tao, Jingyan Han, Ting Fang Alvin Ang, Lei Hou, Chunyu Liu, Joanne M. Murabito, Kathryn L. Lunetta, Jesse Mez, Michael L. Alosco, Thor D. Stein, Xiaoling Zhang, Rhoda Au, Lindsay Farrer, Joseph N. Palmisano, Naomi M. Hamburg, Wei Qiao Qiu   +15 more
wiley   +1 more source