Results 91 to 100 of about 272,971 (193)
Journal of Thrombosis and Haemostasis, 2022 BACKGROUND The platelet-signaling receptor glycoprotein VI (GPVI) is a promising antithrombotic target. We have previously raised a series of high-affinity nanobodies (Nbs) against GPVI and identified Nb2, Nb21, and Nb35 as potent GPVI inhibitors.
Foteini-Nafsika Damaskinaki +9 more
semanticscholar +1 more source
Gut Medicine, Volume 2, Issue 1, Page 40-57, March 2026.ABSTRACT Sepsis‐related liver injury (SRLI) involves multiple interrelated pathological processes, including excessive inflammation, oxidative imbalance, mitochondrial dysfunction, dysregulated autophagy, and microcirculatory impairment. Increasing evidence indicates that traditional Chinese medicine (TCM)–based interventions, particularly Chinese ...
Xiang Yunsheng, Yan Yumeng
wiley +1 more source
Role of osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand axis in nonalcoholic fatty liver disease [PDF]
, 2018 Concomitantly with the increase in the prevalences of overweight/obesity, nonalcoholic fatty liver disease (NAFLD) has worldwide become the main cause of chronic liver disease in both adults and children.
Andreoli, Gian Marco +4 more
core +1 more source
Biomedicines, 2021 Monomeric C-reactive protein (mCRP), the activated isoform of CRP, induces tissue damage in a range of inflammatory pathologies. Its detection in infarcted human brain tissue and its experimentally proven ability to promote dementia with Alzheimer’s ...
E. García-Lara +12 more
semanticscholar +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.ABSTRACT Ulcerative colitis (UC) is a chronic, inflammatory bowel disease with limited clinical treatment. Traditional Chinese medicinal ingredients honokiol and magnolol have potential anti‐inflammatory and gastrointestinal protective effects. However, their anti‐inflammatory potential has not been investigated in UC.
Zhaoxu Cai +5 more
wiley +1 more source
The Certification of the Mass Concentration of C-Reactive Protein in Human Serum - Certified Reference Material ERM®-DA474/IFCC [PDF]
, 2011 This report describes the production of ERM-DA474/IFCC, a human serum material certified for C-reactive protein. The material has been produced following ISO Guide 34:2009.
AUCLAIR Guy +9 more
core +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 878-894, February 2026.Abstract Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and the visceral pericardium, exerting direct paracrine and vasocrine effects on the heart and coronary vessels. Under physiological conditions, EAT supports myocardial energy metabolism and thermoregulation through fatty acid supply and
Elisabeth Heuboeck +2 more
wiley +1 more source
Protein Target Highlights in CASP16: Insights From the Structure Providers
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 25-50, January 2026.ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander +34 more
wiley +1 more source
CRP immunodeposition and proteomic analysis in abdominal aortic aneurysm.
PLoS ONE, 2021 ObjectiveThe molecular mechanisms of the degeneration of the aortic wall in abdominal aortic aneurysm (AAA) are poorly understood. The monomeric form of C-reactive protein (mCRP) is deposited in damaged cardiovascular organs and aggravates the prognosis;
Eun Na Kim +9 more
doaj +1 more source
The pathological Trento variant of alpha-1-antitrypsin (E75V) shows non-classical behaviour during polymerization [PDF]
, 2017 Severe alpha-1-antitrypsin deficiency (AATD) is most frequently associated with the alpha-1-antitrypsin (AAT) Z variant (E342K). ZZ homozygotes exhibit accumulation of AAT as polymers in the endoplasmic reticulum of hepatocytes.
Bodker +50 more
core +2 more sources