Results 1 to 10 of about 66,572 (210)

Autophagy inSaccharomyces cerevisiaerequires the monomeric GTP-binding proteins, Arl1 and Ypt6 [PDF]

Autophagy, 2016
Macroautophagy/autophagy is a cellular degradation process that sequesters organelles or proteins into a double-membrane structure called the phagophore; this transient compartment matures into an autophagosome, which then fuses with the lysosome or vacuole to allow hydrolysis of the cargo.
Shu Yang, Anne G. Rosenwald
europepmc   +8 more sources

The Roles of Monomeric GTP-Binding Proteins in Macroautophagy in Saccharomyces cerevisiae [PDF]

International Journal of Molecular Sciences, 2014
Autophagy is a cellular degradation process that sequesters components into a double-membrane structure called the autophagosome, which then fuses with the lysosome or vacuole for hydrolysis and recycling of building blocks. Bulk phase autophagy, also known as macroautophagy, controlled by specific Atg proteins, can be triggered by a variety of ...
Shu Yang, Anne G. Rosenwald
europepmc   +7 more sources

Ethylene Rapidly Up-Regulates the Activities of Both Monomeric GTP-Binding Proteins and Protein Kinase(s) in Epicotyls of Pea [PDF]

Plant Physiology, 2003
Abstract It is demonstrated that, in etiolated pea (Pisum sativum) epicotyls, ethylene affects the activation of both monomeric GTP-binding proteins (monomeric G-proteins) and protein kinases. For monomeric G-proteins, the effect may be a rapid (2 min) and bimodal up-regulation, a transiently unimodal activation, or a transient down ...
G. V. Novikova, I. E. Moshkov, Luis A. J. Mur, Aileen R. Smith, Michael A. Hall   +4 more
semanticscholar   +6 more sources

Study of the Interaction of the Myelin Monomeric GTP‐Binding Proteins with Other Brain Proteins [PDF]

Journal of Neurochemistry, 1997
Abstract: Although several monomeric GTP‐binding proteins have been found in myelin, the signaling pathways in which they operate are not known. To define these signaling pathways we searched for specific target proteins that interact with the myelin monomeric GTP‐binding proteins. A blot overlay approach was used.
Muhammad Farooq, A G Rodriguez-Gabin, Jorge N. Larocca, William T. Norton   +3 more
semanticscholar   +5 more sources

Ethylene Regulates Monomeric GTP-Binding Protein Gene Expression and Activity in Arabidopsis [PDF]

Plant Physiology, 2003
AbstractEthylene rapidly and transiently up-regulates the activity of several monomeric GTP-binding proteins (monomeric G proteins) in leaves of Arabidopsis as determined by two-dimensional gel electrophoresis and autoradiographic analyses. The activation is suppressed by the receptor-directed inhibitor 1-methylcyclopropene.
G. V. Novikova, Michael A. Hall, I. E. Moshkov, Luis A. J. Mur, Aileen R. Smith   +4 more
semanticscholar   +6 more sources

Characterization of the Interaction of the Monomeric GTP‐Binding Protein Rab3a with Geranylgeranyl Transferase II [PDF]

European Journal of Biochemistry, 1996
The monomeric GTP‐binding protein Rab3a controls exocytosis in neuroendocrine and neuronal cells. Like other members of the Rab family, Rab3a is posttranslationally modified by the addition of hydrophobic geranylgeranyl groups to its C‐terminus. The geranylgeranylation reaction is catalysed by the heterotrimeric geranylgeranyl transferase II.
Jean-Pierre Henry, Ludger Johannes, Franck Perez, François Darchen, Marie-Pierre Laran-Chich   +4 more
openaire   +3 more sources

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, EarlyView., 2023
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Characterization of Two Alternately Spliced Forms of Phospholipase D1 [PDF]

Journal of Biological Chemistry, 1997
We previously reported the cloning of a cDNA encoding human phosphatidylcholine-specific phospholipase D1 (PLD1), an ADP-ribosylation factor (ARF)-activated phosphatidylcholine-specific phospholipase D (Hammond, S. M., Tsung, S., Autschuller, Y., Rudge, S. A., Rose, K., Engebrecht, J., Morris, A. J., and Frohman, M. A. (1995) J. Biol. Chem.
Yoshinori Nozawa, Karen Cadwallader, Shigeru Nakashima, Scott M. Hammond, Andrew J. Morris, Glenn D. Prestwich, Glenn D. Prestwich, Simon J. Cook, John M. Jenco, Qu Ming Gu, Michael A. Frohman   +10 more
openaire   +3 more sources

Leukotriene BLT2 Receptor Monomers Activate the Gi2 GTP-binding Protein More Efficiently than Dimers [PDF]

Journal of Biological Chemistry, 2010
Accumulating evidence indicates that G protein-coupled receptors can assemble as dimers/oligomers but the role of this phenomenon in G protein coupling and signaling is not yet clear. We have used the purified leukotriene B(4) receptor BLT2 as a model to investigate the capacity of receptor monomers and dimers to activate the adenylyl cyclase ...
Arcemisbehere, Laure, Sen, Tuhinadri, Boudier, Laure, Balestre, Marie-Noëlle, Gaibelet, Gérald, Detouillon, Emilie, Orcel, Hélène, Mendre, Christiane, Rahmeh, Rita, Granier, Sébastien, Vivès, Corinne, Fieschi, Franck, Damian, Marjorie, Durroux, Thierry, Baneres, Jean-Louis, Mouillac, Bernard   +15 more
openaire   +5 more sources

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source