Nanoclustering as a dominant feature of plasma membrane organization [PDF]
Nature Communications, 2014 Early studies have revealed that some mammalian plasma membrane proteins exist in small nanoclusters. The advent of super-resolution microscopy has corroborated and extended this picture, and led to the suggestion that many, if not most, membrane ...
Cambi, Alessandra +4 more
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Neurology International, 2023 Recent discoveries suggest links between abnormalities in cell morphogenesis in the brain and the functional deficiency of molecules controlling signal transduction in glial cells such as oligodendroglia.
Shoya Fukatsu +8 more
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A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3
eLife, 2022 Core histones package chromosomal DNA and regulate genomic transactions, with their nuclear import and deposition involving importin-β proteins and a dedicated repertoire of histone chaperones. Previously, a histone H3-H4 dimer has been isolated bound to
Alonso Javier Pardal +1 more
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Structure of UreG/UreF/UreH complex reveals how urease accessory proteins facilitate maturation of Helicobacter pylori urease. [PDF]
PLoS Biology, 2013 Urease is a metalloenzyme essential for the survival of Helicobacter pylori in acidic gastric environment. Maturation of urease involves carbamylation of Lys219 and insertion of two nickel ions at its active site. This process requires GTP hydrolysis and
Yu Hang Fong +5 more
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Potassium acts as a GTPase-activating element on each nucleotide-binding domain of the essential Bacillus subtilis EngA. [PDF]
PLoS ONE, 2012 EngA proteins form a unique family of bacterial GTPases with two GTP-binding domains in tandem, namely GD1 and GD2, followed by a KH (K-homology) domain.
Anne-Emmanuelle Foucher +4 more
doaj +1 more source
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. [PDF]
PLoS ONE, 2012 Leucine-rich repeat kinase 1 and 2 (LRRK1 and LRRK2) are large multidomain proteins containing kinase, GTPase and multiple protein-protein interaction domains, but only mutations in LRRK2 are linked to familial Parkinson's disease (PD).
Laura Civiero +13 more
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The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. [PDF]
PLoS ONE, 2011 Heterotrimeric G protein α subunits are activated upon exchange of GDP for GTP at the nucleotide binding site of Gα, catalyzed by guanine nucleotide exchange factors (GEFs). In addition to transmembrane G protein-coupled receptors (GPCRs), which act on G
Celestine J Thomas +7 more
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Role for Rab10 in Methamphetamine-Induced Behavior. [PDF]
PLoS ONE, 2015 Lipid rafts are specialized, cholesterol-rich membrane compartments that help to organize transmembrane signaling by restricting or promoting interactions with subsets of the cellular proteome.
Scott M Vanderwerf +6 more
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Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator [PDF]
, 2014 Diguanylate cyclases (DGC) and phosphodiesterases (PDE) respectively synthesise and hydrolyse the secondary messenger cyclic dimeric GMP (c-di-GMP), and both activities are often found in a single protein.
Keevil, Charles William +5 more
core +1 more source
A gradient-forming MipZ protein mediating the control of cell division in the magnetotactic bacterium Magnetospirillum gryphiswaldense [PDF]
, 2019 Cell division needs to be tightly regulated and closely coordinated with other cellular processes to ensure the generation of fully viable offspring.
Bramkamp, M. +8 more
core +1 more source