Results 11 to 20 of about 40,314 (122)

ZapA uses a two-pronged mechanism to facilitate Z ring formation in <i>Escherichia coli</i>. [PDF]

mLife
Abstract The tubulin‐like protein FtsZ assembles into the Z ring that leads to the assembly and activation of the division machinery in most bacteria. ZapA, a widely conserved protein that interacts with FtsZ, plays a pivotal role in organizing FtsZ filaments into a coherent Z ring.
Cui Y, Gong H, Yan D, Li H, Yang W, Li Y, Chen X, Lutkenhaus J, Huang SY, Yang X, Du S.   +10 more
europepmc   +2 more sources

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies. [PDF]

FASEB J
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Larasati YA, de Meritens CR, Stoeber M, Katanaev VL, Solis GP.   +4 more
europepmc   +2 more sources

Potassium acts as a GTPase-activating element on each nucleotide-binding domain of the essential Bacillus subtilis EngA. [PDF]

PLoS ONE, 2012
EngA proteins form a unique family of bacterial GTPases with two GTP-binding domains in tandem, namely GD1 and GD2, followed by a KH (K-homology) domain.
Anne-Emmanuelle Foucher, Jean-Baptiste Reiser, Christine Ebel, Dominique Housset, Jean-Michel Jault   +4 more
doaj   +1 more source

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. [PDF]

PLoS ONE, 2012
Leucine-rich repeat kinase 1 and 2 (LRRK1 and LRRK2) are large multidomain proteins containing kinase, GTPase and multiple protein-protein interaction domains, but only mutations in LRRK2 are linked to familial Parkinson's disease (PD).
Laura Civiero, Renée Vancraenenbroeck, Elisa Belluzzi, Alexandra Beilina, Evy Lobbestael, Lauran Reyniers, Fangye Gao, Ivan Micetic, Marc De Maeyer, Luigi Bubacco, Veerle Baekelandt, Mark R Cookson, Elisa Greggio, Jean-Marc Taymans   +13 more
doaj   +1 more source

The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. [PDF]

PLoS ONE, 2011
Heterotrimeric G protein α subunits are activated upon exchange of GDP for GTP at the nucleotide binding site of Gα, catalyzed by guanine nucleotide exchange factors (GEFs). In addition to transmembrane G protein-coupled receptors (GPCRs), which act on G
Celestine J Thomas, Klára Briknarová, Jonathan K Hilmer, Navid Movahed, Brian Bothner, John P Sumida, Gregory G Tall, Stephen R Sprang   +7 more
doaj   +1 more source

Role for Rab10 in Methamphetamine-Induced Behavior. [PDF]

PLoS ONE, 2015
Lipid rafts are specialized, cholesterol-rich membrane compartments that help to organize transmembrane signaling by restricting or promoting interactions with subsets of the cellular proteome.
Scott M Vanderwerf, David C Buck, Phillip A Wilmarth, Leila M Sears, Larry L David, David B Morton, Kim A Neve   +6 more
doaj   +1 more source

Effects of site-directed mutagenesis of mglA on motility and swarming of Myxococcus xanthus

BMC Microbiology, 2010
Background The mglA gene from the bacterium Myxococcus xanthus encodes a 22kDa protein related to the Ras superfamily of monomeric GTPases. MglA is required for the normal function of A-motility (adventurous), S-motility (social), fruiting body ...
Burke Neal S, Fremgen Sarah A, Hartzell Patricia L   +2 more
doaj   +1 more source

Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells

Molecular Cancer, 2012
Background Rab proteins constitute a large family of monomeric GTP-binding proteins that regulate intracellular vesicle transport. Several Rab proteins, including rab31, have been shown to affect cancer progression and are related with prognosis in ...
Grismayer Bettina, Sölch Susanne, Seubert Bastian, Kirchner Thomas, Schäfer Sonja, Baretton Gustavo, Schmitt Manfred, Luther Thomas, Krüger Achim, Kotzsch Matthias, Magdolen Viktor   +10 more
doaj   +1 more source

Actin filament organization in activated mast cells is regulated by heterotrimeric and small GTP-binding proteins

Journal of Cell Biology, 1994
Rat peritoneal mast cells, both intact and permeabilized, have been used widely as model secretory cells. GTP-binding proteins and calcium play a major role in controlling their secretory response.
Jim C. Norman, Leo S. Price, Anne J Ridley, Anita C. Hall, A. Koffer   +4 more
semanticscholar   +1 more source

Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha.

The Journal of biological chemistry, 1997
We previously reported the cloning of a cDNA encoding human phosphatidylcholine-specific phospholipase D1 (PLD1), an ADP-ribosylation factor (ARF)-activated phosphatidylcholine-specific phospholipase D (Hammond, S. M., Tsung, S., Autschuller, Y., Rudge, S. A., Rose, K., Engebrecht, J., Morris, A. J., and Frohman, M. A. (1995) J. Biol. Chem.
S M, Hammond, J M, Jenco, S, Nakashima, K, Cadwallader, Q, Gu, S, Cook, Y, Nozawa, G D, Prestwich, M A, Frohman, A J, Morris   +9 more
openaire   +2 more sources