Results 21 to 30 of about 29,796 (140)

A Peptide Core Motif for Binding to Heterotrimeric G Protein α Subunits [PDF]

, 2005
Recently, in vitro selection using mRNA display was used to identify a novel peptide sequence that binds with high affinity to G{alpha}i1. The peptide was minimized to a 9-residue sequence (R6A-1) that retains high affinity and specificity for the GDP ...
Adhikari, Anirban, Austin, Ryan J., Ja, William W., Roberts, Richard W., Sprang, Stephen R.   +4 more
core   +2 more sources

Ras hyperactivation versus overexpression : Lessons from Ras dynamics in Candida albicans [PDF]

, 2018
We thank Prof. Neta Dean for the CIp10ADH1-Cherry plasmid and Prof. Aaron Mitchell for the BWP17 strain. We gratefully acknowledge Prof. Sudipta Maiti, TIFR, Mumbai, India for providing the data acquisition software.
Haokip, Dominic T, Jain, Priyanka, Khan, Mohammad Firoz, Komath, Sneha Sudha, Pal, Nibedita, Pratyusha, Vavilala A, Sen, Sobhan, Sethi, Subhash Chandra, Singh, Sneh Lata, Victoria, Guiliana Soraya, Yadav, Bhawna   +10 more
core   +3 more sources

Effects of site-directed mutagenesis of mglA on motility and swarming of Myxococcus xanthus

BMC Microbiology, 2010
Background The mglA gene from the bacterium Myxococcus xanthus encodes a 22kDa protein related to the Ras superfamily of monomeric GTPases. MglA is required for the normal function of A-motility (adventurous), S-motility (social), fruiting body ...
Burke Neal S, Fremgen Sarah A, Hartzell Patricia L   +2 more
doaj   +1 more source

Structural insight into TPX2-stimulated microtubule assembly [PDF]

, 2017
During mitosis and meiosis, microtubule (MT) assembly is locally upregulated by the chromatin-dependent Ran-GTP pathway. One of its key targets is the MT-associated spindle assembly factor TPX2.
Nogales, Eva, Roostalu, Johanna, Surrey, Thomas, Zhang, Rui   +3 more
core   +2 more sources

Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells

Molecular Cancer, 2012
Background Rab proteins constitute a large family of monomeric GTP-binding proteins that regulate intracellular vesicle transport. Several Rab proteins, including rab31, have been shown to affect cancer progression and are related with prognosis in ...
Grismayer Bettina, Sölch Susanne, Seubert Bastian, Kirchner Thomas, Schäfer Sonja, Baretton Gustavo, Schmitt Manfred, Luther Thomas, Krüger Achim, Kotzsch Matthias, Magdolen Viktor   +10 more
doaj   +1 more source

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Phosphorylation regulates the assembly of chloroplast import machinery [PDF]

, 2008
Chloroplast function depends on the translocation of cytosolically synthesized precursor proteins into the organelle. The recognition and transfer of most precursor proteins across the outer membrane depend on a membrane inserted complex.
Höfle, Anja, Mirus, Oliver, Oreb, Igor-Mislav, Schleiff, Enrico   +3 more
core   +2 more sources

Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha.

The Journal of biological chemistry, 1997
We previously reported the cloning of a cDNA encoding human phosphatidylcholine-specific phospholipase D1 (PLD1), an ADP-ribosylation factor (ARF)-activated phosphatidylcholine-specific phospholipase D (Hammond, S. M., Tsung, S., Autschuller, Y., Rudge, S. A., Rose, K., Engebrecht, J., Morris, A. J., and Frohman, M. A. (1995) J. Biol. Chem.
S M, Hammond, J M, Jenco, S, Nakashima, K, Cadwallader, Q, Gu, S, Cook, Y, Nozawa, G D, Prestwich, M A, Frohman, A J, Morris   +9 more
openaire   +2 more sources

Substrate-Induced Self-Assembly of Cooperative Catalysts [PDF]

, 2018
Dissipative self-assembly processes in Nature rely on chemical fuels that activate proteins for assembly through the formation of a noncovalent complex.
Alberts, Ashkenasy, Boekhoven, Boekhoven, Bowne-Anderson, Caplow, Che, Chen, Cheng, Colomer, Dambenieks, Datta, David-Pfeuty, De, Del Grosso, Della Sala, della Sala, Dhiman, Dhiman, England, Fanlo-Virgós, Gruber, Grzybowski, Hao, Hess, Hoffmann, Kariyawasam, Kassem, Köstereli, Li, Maiti, Manea, Mattia, Merindol, Mishra, Pezzato, Pezzato, Ragazzon, Sasaki, Sawczyk, Sorrenti, Tena-Solsona, Tena-Solsona, van Ravensteijn, van Rossum, Wang, Wei, Wood, Zana, Zaupa   +49 more
core   +1 more source

The Cool-2/α-Pix Protein Mediates a Cdc42-Rac Signaling Cascade [PDF]

, 2005
Background:Cloned-out of library-2 (Cool-2)/PAK-interactive exchange factor (α-Pix) was identified through its ability to bind the Cdc42/Rac target p21-activated kinase (PAK) and has been implicated in certain forms of X-linked mental retardation as well
Baird, Dan, Feng, Qiyu, Cerione, Richard A.   +2 more
core   +3 more sources