Phosphorylation regulates the assembly of chloroplast import machinery [PDF]
, 2008 Chloroplast function depends on the translocation of cytosolically synthesized precursor proteins into the organelle. The recognition and transfer of most precursor proteins across the outer membrane depend on a membrane inserted complex.
Höfle, Anja +3 more
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Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif [PDF]
, 2017 Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have
Baillie, George S. +14 more
core +1 more source
Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. [PDF]
, 2015 Microtubule dynamics and polarity stem from the polymerization of αβ-tubulin heterodimers. Five conserved tubulin cofactors/chaperones and the Arl2 GTPase regulate α- and β-tubulin assembly into heterodimers and maintain the soluble tubulin pool in the ...
Al-Bassam, Jawdat +7 more
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The Ras G Domain Lacks the Intrinsic Propensity to Form Dimers [PDF]
, 2015 Ras GTPase is a molecular switch controlling a number of cellular pathways including growth, proliferation, differentiation, and apoptosis. Recent reports indicated that Ras undergoes dimerization at the membrane surface through protein-protein ...
Galiakhmetov, Azamat R. +2 more
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Lymphotactin: how a protein can adopt two folds [PDF]
J. Chem. Phys. 131 (2009) 245105-245110, 2009 Metamorphic proteins like Lymphotactin are a notable exception of the empirical principle that structured natural proteins possess a unique three dimensional structure. In particular, the human chemokine lymphotactin protein (Ltn) exists in two distinct conformations (one monomeric and one dimeric) under physiological conditions.
arxiv +1 more source
Effects of site-directed mutagenesis of
BMC Microbiology, 2010 Background The mglA gene from the bacterium Myxococcus xanthus encodes a 22kDa protein related to the Ras superfamily of monomeric GTPases. MglA is required for the normal function of A-motility (adventurous), S-motility (social), fruiting body ...
Burke Neal S +2 more
doaj +1 more source
Impact of the protein composition on the structure and viscoelasticity of polymer-like gluten gels [PDF]
J. Phys.: Condens. Matter 33 (2021) 144001, 2021 We investigate the structure of gluten polymer-like gels in a binary mixture of water/ethanol, $50/50$ v/v, a good solvent for gluten proteins. Gluten comprises two main families of proteins, monomeric gliadins and polymer glutenins. In the semi-dilute regime, scattering experiments highlight two classes of behavior, akin to standard polymer solution ...
arxiv +1 more source
Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells
Molecular Cancer, 2012 Background Rab proteins constitute a large family of monomeric GTP-binding proteins that regulate intracellular vesicle transport. Several Rab proteins, including rab31, have been shown to affect cancer progression and are related with prognosis in ...
Grismayer Bettina +10 more
doaj +1 more source
Towards multistage modelling of protein dynamics with monomeric Myc oncoprotein as an example [PDF]
Phys. Rev. E 95, 032406 (2017), 2016 We propose to combine a mean field approach with all atom molecular dynamics into a multistage algorithm that can model protein folding and dynamics over very long time periods yet with atomic level precision. As an example we investigate an isolated monomeric Myc oncoprotein that has been implicated in carcinomas including those in colon, breast and ...
arxiv +1 more source
A model of membrane contraction predicting initiation and completion of bacterial cell division [PDF]
, 2013 Bacterial cell division involves a complex and dynamic sequence of events whereby polymers of the protein FtsZ assemble at the division plane and rearrange to achieve the goal of contracting the cell membrane at the site of cell division, thus dividing ...
Alison Rodger +59 more
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