Results 61 to 70 of about 15,328 (112)

Substrate-Induced Self-Assembly of Cooperative Catalysts [PDF]

, 2018
Dissipative self-assembly processes in Nature rely on chemical fuels that activate proteins for assembly through the formation of a noncovalent complex.
Alberts, Ashkenasy, Boekhoven, Boekhoven, Bowne-Anderson, Caplow, Che, Chen, Cheng, Colomer, Dambenieks, Datta, David-Pfeuty, De, Del Grosso, Della Sala, della Sala, Dhiman, Dhiman, England, Fanlo-Virgós, Gruber, Grzybowski, Hao, Hess, Hoffmann, Kariyawasam, Kassem, Köstereli, Li, Maiti, Manea, Mattia, Merindol, Mishra, Pezzato, Pezzato, Ragazzon, Sasaki, Sawczyk, Sorrenti, Tena-Solsona, Tena-Solsona, van Ravensteijn, van Rossum, Wang, Wei, Wood, Zana, Zaupa   +49 more
core   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

NMR Solution Structure of the N‐Terminal GSPII Domain from the Thermus Thermophilus Traffic ATPase PilF and Reconstruction of its c‐di‐GMP Binding Capability

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
GSPII‐A is the first of three consecutive GSPII domains of PilF from Thermus thermophilus and the only one that does not bind c‐di‐GMP. In this study we solve the structure of GSPII‐A and show the key factors hindering c‐di‐GMP binding. Through mutagenesis, we elucidate the minimal motif conservation needed for c‐di‐GMP recognition. Abstract The cyclic
Konstantin Neißner, Carolin Frohnapfel, Heiko Keller, Elke Duchardt‐Ferner, Vanessa Schneider, Zeinab Kamjou, Beate Averhoff, Jens Wöhnert   +7 more
wiley   +1 more source

Assignments of backbone 1H, 13C and 15N resonances in H-Ras (1–166) complexed with GppNHp at physiological pH [PDF]

, 2012
The small GTPase Ras is an important signaling molecule acting as a molecular switch in eukaryotic cells. Recent findings of global conformational exchange and a putative allosteric binding site in the G domain of Ras opened an avenue to understanding ...
Kovriguine, Evgueni, O\u27Connor, Casey
core   +1 more source

The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]

, 2016
Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan, Lewko, Dawid, Majsterek, Ireneusz, Nowak, Alicja, Pytel, Dariusz, Rozpędek, Wioletta   +5 more
core   +1 more source

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity. [PDF]

, 2019
Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are ...
Budaitis, Breane G, Grant, Barry J, Jariwala, Shashank, Lang, Matthew J, Reinemann, Dana N, Scarabelli, Guido, Schimert, Kristin I, Sept, David, Verhey, Kristen J   +8 more
core   +1 more source

Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]

, 2017
In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M, Conn, Adam B, Diggs, Stephen, Fan, Haitian, Gamper, Howard B, Hahm, Joseph, Hou, Ya-Ming, O'Leary, Seán E, Wang, Yinsheng, Williams, Preston B   +9 more
core   +1 more source

Role of the PAS2 domain of the NifL regulatory protein in redox signal transduction [PDF]

, 2010
EThOS - Electronic Theses Online ServiceGBUnited ...
Slavny, Peter
core  

Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments [PDF]

, 2009
TGases (transglutaminases) are a class of calcium-dependent enzymes that catalyse the interactions between acyl acceptor glutamyl residues and amine donors, potentially making crosslinks between proteins.
Bonner, PLR, Cai, G, Cresti, M, Del, Duca, Serafini-Fracassini, D   +4 more
core  

The interaction network of rhodopsin involving the heterotrimeric G‐protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes [PDF]

, 2014
Maike Köster, Daniele Dell’Orco, Karl‐Wilhelm Koch   +2 more
openalex   +1 more source