Results 151 to 160 of about 242,176 (299)

Oxidative Stress-Related Parthanatos of Circulating Mononuclear Leukocytes in Heart Failure. [PDF]

Oxid Med Cell Longev, 2017
Bárány T, Simon A, Szabó G, Benkő R, Mezei Z, Molnár L, Becker D, Merkely B, Zima E, Horváth EM.   +9 more
europepmc   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates. [PDF]

Sci Rep, 2019
Gayen Nee' Betal S, Murthy S, Favara M, Fong G, Chan JSY, Addya S, Shaffer TH, Greenspan J, Bhandari V, Rahman I, Aghai ZH.   +10 more
europepmc   +1 more source

Subset‐specific and tissue‐specific expression of NK‐cell markers and killer immunoglobulin‐like receptors: Implications for NK‐cell clonality assessment

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate immunophenotypic evaluation of natural killer (NK)‐cell neoplasms is challenging because NK‐cells lack somatically rearranged antigen receptors, are comprised of phenotypically distinct subsets, and exhibit tissue‐specific subset distribution. We developed a flow cytometry (FC) panel for NK‐cell immunophenotypic analysis and clonality
Valerie Woodings, Orrin Koepke, Jason E. Love, Alireza Torabi, Lianqun Qiu, Jonathan R. Fromm, Sindhu Cherian, Afshin Shameli   +7 more
wiley   +1 more source

Isoforskolin and forskolin attenuate lipopolysaccharide-induced inflammation through TLR4/MyD88/NF-κB cascades in human mononuclear leukocytes. [PDF]

Phytother Res, 2019
Du X, Shi R, Wang Y, Wu W, Sun S, Dai Z, Chen C, Weng Z, Li X, Liu Q, Zhang L, Saidian M, Yang W.   +12 more
europepmc   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

Exploration, EarlyView.
Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia   +23 more
wiley   +1 more source

Micro/Nanostructured Materials and Microfluidic Diagnostic Platforms Enable Multimodal Detection of Circulating Tumor Cells

Exploration, EarlyView.
Engineered micro/nanomaterials enable high‐efficiency CTC capture, release, and multimodal molecular profiling. Integrated with AI‐driven analytics, these platforms decode tumor heterogeneity and metastatic dynamics, advancing real‐time monitoring and precision oncology through DNA, RNA, and protein cross‐scale data fusion.
Hao Li, Jiaojiao Sun, Kunguo Liu, Shijie Wang, Bowen Fu, Hong Zhu, Peng Cao, Xin Han   +7 more
wiley   +1 more source

Cytokine production of mononuclear leukocytes in response to respiratory syncytial virus is increased in COPD but suppressed in non-COPD tobacco smokers. [PDF]

Mol Med
Yanik SD, Jamal Jameel K, Rohde S, Bürger P, Bülthoff E, Grunwald T, Kronsbein J, Koch A, Edwards MR, Tenbusch M, Knobloch J.   +10 more
europepmc   +1 more source

HSP70 in human polymorphonuclear and mononuclear leukocytes: comparison of the protein content and transcriptional activity of HSPA genes. [PDF]

Cell Stress Chaperones, 2017
Boyko AA, Azhikina TL, Streltsova MA, Sapozhnikov AM, Kovalenko EI.   +4 more
europepmc   +1 more source