Results 61 to 70 of about 80,122 (306)

Detection of angiotensin II in supernatants of stimulated mononuclear leukocytes by matrix-assisted laser desorption ionization time-of-flight/time-of-flight mass analysis [PDF]

, 2005
Angiotensin II ( Ang II) is the major vasoactive component of the renin- angiotensin system. Several components of the renin- angiotensin system have been demonstrated in different tissues.
TOLLE, M, GOBOM, J, Vanholder, R., Giebing, G, KARADOGAN, S, SCHLUTER, H, Jankowski, V, HENNING, L, Schönfelder, G., Krakow, A., van der Giet, M., Vanholder, R, Gustavsson, Niklas, Karadogan, S., Webb, J., JANKOWSKI, J, Jankowski, Vera, Tölle, M., Schlüter, H., Vanholder, Raymond, ZIDEK, W, Gustavsson, Niklas,, SCHONFELDER, G, Henning, L., Gustavsson, N., KRAKOW, A, GUSTAVSSON, N, Zidek, W., Gobom, J., HILGERS, KF, Lehrach, H., Hilgers, K., WEBB, J, GIEBING, N, Jankowski, V., Lund University., Giebing, G., VAN DER GIET, M, LEHRACH, H   +38 more
core   +2 more sources

Regulation of cholesterol biosynthesis in sitosterolemia: effects of lovastatin, cholestyramine, and dietary sterol restriction.

Journal of Lipid Research, 1991
We investigated the effects of lovastatin, cholestyramine, and dietary sterol restriction on cholesterol synthesis and low density lipoprotein receptor function in freshly isolated mononuclear leukocytes from two unrelated sitosterolemic families.
LB Nguyen, M Cobb, S Shefer, G Salen, GC Ness, GS Tint   +5 more
doaj   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Multiple effects of dipyridamole on neutrophils and mononuclear leukocytes: adenosine-dependent and adenosine-independent mechanisms [PDF]

, 1991
Dipyridamole is an antithrombotic drug that has been shown to influence not only platelet function but also some aspects of leukocyte activation.
S. Colli, E. Tremoli
core  

Mononuclear Leukocyte Infiltrate in Extraplacental Membranes and Preterm Delivery [PDF]

American Journal of Epidemiology, 2013
Large numbers of polymorphonuclear leukocytes in the amnion and chorion define histological chorioamnionitis (HCA), a condition linked to spontaneous preterm delivery (PTD). Less is known about placental patterns of mononuclear leukocyte (MNL) density and PTD.
Claudia, Holzman, Patricia K, Senagore, Jianling, Wang   +2 more
openaire   +2 more sources

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Androgen binding sites in peripheral human mononuclear leukocytes of healthy males and females. [PDF]

, 1994
Androgen binding sites have been identified in circulating human mononuclear leukocytes of healthy donors of both sexes. Cells were separated from blood samples on a Ficoll gradient and incubated with different concentrations of [3H]testosterone in the ...
BAUR S., ARMANINI, DECIO, MEURER M, LINDL U, KELLER U, KUHNLE U   +5 more
core   +1 more source

A comparison of delipidated sera used in studies of sterol synthesis by human mononuclear leukocytes.

Journal of Lipid Research, 1979
Sterol synthesis in human mononuclear leukocytes is stimulated by delipidated serum. Synthesis in media containing serum delipidated by three different methods is compared.
H R Slater, F W Robertson
doaj   +1 more source

Bradykinin-inactivating activity of mononuclear leukocytes.

Ensho, 1986
Bradykinin-inactivating activity of mononuclear leukocytes was examined using guinea-pig macrophages and lymphocytes. Intact macrophages rapidly inactivated bradykinin. Bradykinin-inactivating activity of macrophages was present in the membrane and cytosol fractions but not in the nuclear and granular fractions.
Nagaoka, Isao, Yamashita, Tatsuhisa, Yasuura, Shinichi   +2 more
openaire   +2 more sources

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source