Results 81 to 90 of about 21,030 (219)

Tumor desialylation surpasses anti‐PD‐L1 checkpoint therapy in restoring anti‐tumor immunity in a murine model for colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Our research highlights how tumor sialylation affects tumor growth and reshapes the immune tumor microenvironment in colorectal cancer. We demonstrate for the first time that complete removal of sialic acids from colorectal tumor cells elicits a robust anti‐tumor immune response, but does not enhance anti‐PD‐L1 blockade efficacy.
Irene van der Haar Àvila, Tao Zhang, Victor Lorrain, Eelco Keuning, Laraib Amir Ali, Cora Chadick, Sara García‐García, Louis Boon, Noortje de Haan, Juan J. García‐Vallejo, Yvette van Kooyk, Sandra J. van Vliet   +11 more
wiley   +1 more source

Applications of bioactive herbal extracts in dressing materials for skin wound repair: Ingredients, mechanisms and innovations

Interdisciplinary Medicine, EarlyView.
Abstract The skin, as the body's largest organ, plays essential roles in protection, immune regulation, and homeostasis. Skin trauma, especially chronic wounds such as diabetic ulcers, poses significant clinical challenges. Traditional treatments, while often effective, can be costly and pose risks.
Boxiang Yang, Jingyuan Xu, Siyi Liu, Chaoying Wu, Yi Li, Mingqi Lv, Tingting Chen, Chuanrong Zhao, Daojun Pu, Chaojun Tang, Anna Malashicheva, Guangchao Zang, Guixue Wang   +12 more
wiley   +1 more source

From shake flasks to a bench‐scale bioreactor: scaling up exopolysaccharide production in fed‐batch cultivation of Ensifer meliloti SEMIA 135

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND This study investigates the production scale‐up of exopolysaccharide (EPS) by Ensifer meliloti SEMIA 135 from shake flasks to a 5 L bench‐scale fed‐batch bioreactor. Soybean molasses was the cost‐effective nutrient source. The primary aim was to improve conditions for maximizing EPS yield and minimizing production costs.
Rui dos Santos Ferreira Filho, Janaína Fernandes de Medeiros Burkert, Carlos André Veiga Burkert   +2 more
wiley   +1 more source

Enhancing sheep milk yogurt with prickly pear (Opuntia ficus‐indica L.) flours (peel and pulp): nutritional, techno‐functional, and sensory evaluation

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The aim of the present work was to evaluate the chemical composition and characterize the physicochemical, techno‐functional and antioxidant properties of flours obtained from the peel and pulp of prickly pear and to assess the effect of their incorporation on the composition, physicochemical parameters, microbiology, antioxidant ...
Nuria Muñoz‐Tebar, Carmen Botella‐Martínez, Raquel Lucas‐González, José M. Lorenzo, José Ángel Pérez‐Álvarez, Juana Fernández‐López, Manuel Viuda‐Martos   +6 more
wiley   +1 more source

Sustainable Shell Formulations as Alternative to the Conventional Soft Gelatin Capsules in Pharmaceutical and Nutraceutical Applications. A Review.

Macromolecular Materials and Engineering, EarlyView.
In soft capsules (SCs), four crucial factors can modify the properties of the shell: the shell formulation, its interaction with the fill material, the SC production and its storage conditions. Gelatin is the most used gelling agent for SCs nowadays, but they have some drawbacks which can be solved including other alternative polymers in the shell ...
Francisco Javier Palomero‐Hernández, María Ángela Caballo‐González, Francisco Javier de la Mata, Sandra García‐Gallego   +3 more
wiley   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Nutritional priorities to support GLP‐1 therapy for obesity: A joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society

Obesity, EarlyView.
Abstract Background Glucagon‐like peptide 1 receptor agonists and combination medications (hereafter collectively referred to as GLP‐1s) are shifting the treatment landscape for obesity. However, real‐world challenges and limited clinician and public knowledge on nutritional and lifestyle interventions can limit GLP‐1 efficacy, equitable results, and ...
Dariush Mozaffarian, Monica Agarwal, Monica Aggarwal, Lydia Alexander, Caroline M. Apovian, Shagun Bindlish, Jonathan Bonnet, W. Scott Butsch, Sandra Christensen, Eugenia Gianos, Mahima Gulati, Alka Gupta, Debbie Horn, Ryan M. Kane, Jasdeep Saluja, Deepa Sannidhi, Fatima Cody Stanford, Emily A. Callahan   +17 more
wiley   +1 more source

Glycoproteomics and Its Role in Understanding Bacterial O‐Linked Glycosylation

PROTEOMICS, EarlyView.
ABSTRACT Protein glycosylation is now recognized as a ubiquitous process observed in all domains of life. Within bacterial species, carbohydrates can be attached to multiple residues with glycosylation of serine, threonine, or tyrosine residues via their hydroxyl side chains referred to as O‐linked glycosylation.
Kristian I. Karlic, Hamza Tahir, Nichollas E. Scott   +2 more
wiley   +1 more source

Altered Glycosylation of PSA in Prostate Cancer Tissue

The Prostate, EarlyView.
ABSTRACT Background The glycosylation of proteins is commonly altered in cancer. This offers novel opportunities for cancer biomarker development. As prostate‐specific antigen (PSA) is a glycoprotein, identification of cancer‐specific PSA‐glycoforms is feasible. Such PSA‐glycoforms may provide valuable diagnostic and prognostic information. Methods PSA‐
Hannu Koistinen, Ruusu‐Maaria Merivirta, Timo‐Pekka Lehto, Anna Lempiäinen, Andrew Erickson, Ulf‐Håkan Stenman, Antti Rannikko, Tuomas Mirtti   +7 more
wiley   +1 more source

Novel Flaxseed Gum Nanocomposites are Slow Release Iron Supplements [PDF]

, 2018
Nanocomposites, based on iron salts and soluble flaxseed gum (FG), were prepared as potential treatments of iron deficiency anemia (IDA). FG was extracted, characterized, and formulated into iron-loading nanocomposites via ion-exchange against FeCl_3 ...
Huang, Yu, Liang, Shan, Ma, Xiang, Reaney, Martin J. T., Shim, Youn Young, Wang, Yong   +5 more
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