Results 231 to 240 of about 136,224 (305)

Lactate Dehydrogenase Inhibition Reverts the Fatty Acid‐Induced Neurotoxic Phenotype of Astrocytes

Glia, Volume 74, Issue 3, March 2026.
ALS models display increased LD accumulation. LD accumulation is linked to a neurotoxic phenotype in astrocytes. Lactate dehydrogenase inhibition reverts LD accumulation in ALS astrocytes. ABSTRACT Astrocytes are central to lipid metabolism in the central nervous system.
Daniel Esteve, Mariana Bresque, Daniel Okhuevbie, Sandhya Ramachandran, Mariana Pehar, Marcelo R. Vargas   +5 more
wiley   +1 more source

Longitudinal clinical and preclinical studies identify hetrombopag as a potent chelator for systemic iron overload

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Iron overload (IO) is a pathological condition characterized by excessive iron accumulation, leading to systemic functional impairment. It frequently occurs in patients with congenital or acquired anemia, such as aplastic anemia, who require long‐term transfusions.
Yufei Zhao, Lingxiao Xing, Baohang Zhang, Wenrui Yang, Xiangrong Hu, Xu Liu, Xiawan Yang, Weiru Liang, Yimeng Shi, Jing Hu, Xiaoxia Li, Rui Kang, Guangxin Peng, Yuan Li, Xiao Hu, Youzhen Xiong, Liping Jing, Weiping Yuan, Sidan Li, Fengkui Zhang, Xin Zhao   +20 more
wiley   +1 more source

The Relationship Between Dietary Inflammatory Index and Intermediate‐to‐High‐Risk Cardiovascular‐Kidney‐Metabolic Syndrome and All‐Cause Mortality: The National Health and Nutrition Examination Survey 1999–2018: A Cross‐Sectional and Prospective Cohort Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background The dietary inflammatory index (DII) score quantifies the inflammatory potential of an individual's diet and may be associated with cardiovascular–kidney–metabolic syndrome (CKM) and mortality risk. However, evidence on the relationship between DII and intermediate‐to‐high‐risk cardiovascular–kidney–metabolic syndrome (IH–CKM) is ...
Honglin Li, Mu Lin, Yane Yang, Liyan Wang, Yao Wang, Jiayu Lu, Meiju Li, Yanfei Zhao, Sining Chen, Chenxuan Gao, Chuanwei Zhao   +10 more
wiley   +1 more source

Variation in seed abundance predicts yolk fatty acid composition in a wild population of birds

Journal of Avian Biology, Volume 2026, Issue 2, March 2026.
Bird embryos develop inside eggs, which contain maternal substances that can shape offspring phenotype and fitness. Yolk fatty acids are a key energy source for the developing embryo, with omega‐6 (ω‐6) and omega‐3 (ω‐3) polyunsaturated fatty acids (PUFAs) obtained exclusively from the diet.
Lucia Mentesana, Hong‐Lei Wang, Michaela Hau, Caroline Isaksson, Martin N. Andersson   +4 more
wiley   +1 more source

The Divergent Roles of Dietary Saturated and Monounsaturated Fatty Acids on Nerve Function in Murine Models of Obesity. [PDF]

J Neurosci, 2019
Rumora AE, LoGrasso G, Hayes JM, Mendelson FE, Tabbey MA, Haidar JA, Lentz SI, Feldman EL.   +7 more
europepmc   +1 more source

Natural History of Clinical Phenotypes and Their Biochemical Correlates in Adult X‐Linked Adrenoleukodystrophy

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT X‐linked adrenoleukodystrophy (X‐ALD) is a rare monogenic disorder characterized by marked variability in clinical presentation, age at onset, and disease progression. A deeper understanding of its natural history and the relationship between biochemical markers and clinical phenotypes is essential for improving disease monitoring, patient ...
Julia Lier, Markus Ponleitner, Denny Popp, Lisa Schäfer, Franziska Küstermann, Christof Meigen, Frank Kratzer, Joachim Janda, Jürgen Okun, Rami Abou Jamra, Wolfgang Köhler, Caroline Bergner   +11 more
wiley   +1 more source

The Role of Food Structure on Fatty Acid Bioaccessibility: A Decade of TIM‐1 Simulated Digestion Studies in Review

Molecular Nutrition &Food Research, Volume 70, Issue 6, 29 March 2026.
Lipid and food structure determine when and how macro‐ and micronutrients become bioaccessible. This review compares lipid bioaccessibility from engineered emulsions, breast milk, infant formula, and meat and meat mimics, which couples the effect of cooking temperature on lipid bioaccessibility in meat and eggs. ABSTRACT Food structure has emerged as a
Michael A. Rogers, Amanda J. Wright
wiley   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders

Neuroprotection, Volume 4, Issue 1, Page 30-47, March 2026.
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan, Roshan S. Raghavan, Dawn Li Wei Koh, Wing Yeng Tan, Igor Iezhitsa, Renu Agarwal   +5 more
wiley   +1 more source