Montelukast treats Streptococcus pneumoniae-induced sepsis via antibacterial and anti-inflammatory activities [PDF]
Microbiology SpectrumStreptococcus pneumoniae is a leading causative pathogen of community-acquired pneumonia and sepsis. The increasing prevalence of antibiotic resistance among S. pneumoniae strains poses a major challenge to conventional antibiotic therapies.
Wei Cao +3 more
doaj +2 more sources
Frontiers in Pharmacology, 2022 Inflammatory bowel disease is a chronic autoimmune disorder that may involve entire gastrointestinal tract. The leukotrienes have a role as mediators in the pathophysiology of colitis. Here, we investigated the effect of a leukotriene receptor antagonist,
Behnam Ghorbanzadeh +5 more
doaj +1 more source
The effect of montelukast on depression behavior in rat forced swimming test
Psychiatry and Behavioral Sciences, 2017 Objective: Montelukast (brand name: Singulair), which is used for treatment of chronic asthma, is a leukotriene receptor antagonist. The psychiatric side effects of montelukast use in asthma patients are controversial. The aim of this study is to examine
Ersoz Gonca
doaj +1 more source
Montelukast promotes mitochondrial biogenesis via CREB/PGC-1α in human bronchial epithelial cells
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Bronchial epithelial mitochondrial dysfunction including impaired mitochondrial biogenesis has been linked with the initiation and development of bronchial asthma.
Huan Wang +4 more
doaj +1 more source
The examination of the nephroprotective effect of montelukast sodium and N-acetylcysteine ın renal ıschemia with dimercaptosuccinic acid imaging in a placebo-controlled rat model [PDF]
Acta Cirúrgica Brasileira, 2020 Purpose To determine the nephroprotective effect of NAC and Montelukast Sodium administration against the development of renal damage associated with long warm renal ischemia.
Arif Aydin +9 more
doaj +1 more source
Sleeptalking! Sleepwalking! Side Effects of Montelukast
Case Reports in Pulmonology, 2013 A 16-year-old Caucasian female presented to the pulmonary clinic for a followup on her asthma. Due to the worsening of allergy-related symptoms, therapy with montelukast 10 mg daily was started and resulted in good relief of the patient’s symptoms.
Samer Alkhuja +2 more
doaj +1 more source
Skin rash and mild bruising: Is montelukast a safe drug?
Indian Journal of Respiratory Care, 2018 Montelukast is one of the commonly used drugs in asthma patients. It is prescribed along with inhalational corticosteroids. Although a relatively safe drug, there is a probability of occurrence of skin rashes and skin bruising.
Deep Inder +3 more
doaj +1 more source
Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury
Frontiers in Pharmacology, 2019 Acetaminophen (APAP) is a widely used over-the-counter antipyretic and analgesic drug. Overdose of APAP is the leading cause of hospital admission for acute liver failure.
Shiyun Pu +9 more
doaj +1 more source
Neuropsychiatric events associated with montelukast in patients with asthma: a systematic review
European Respiratory Review, 2023 Background: The United States Food and Drug Administration issued a black box warning on the mental health adverse effects of montelukast in 2020. Age-related effects on the risk of developing specific neuropsychiatric events in montelukast users remain ...
Chris Wai Hang Lo +8 more
doaj +1 more source
Farmacéuticos Comunitarios, 2014 Introducción: El objetivo de este trabajo es analizar la utilización de montelukast en adultos desde tres farmacias comunitarias. Material y métodos: Estudio descriptivo, observacional en tres farmacias comunitarias (enero 2009 - febrero 2013) en ...
Peris Molina MT +3 more
doaj +1 more source