Pediatric Asthma: Where Has Montelukast Gone?
Applied Sciences, 2023 At its introduction in the management of pediatric asthma, montelukast was regarded as a potentially revolutionary drug due to its mechanism of action and easy clinical applicability.
Marco Maglione +3 more
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Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]
, 2008 Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg +12 more
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The effect of montelukast on depression behavior in rat forced swimming test
Psychiatry and Behavioral Sciences, 2017 Objective: Montelukast (brand name: Singulair), which is used for treatment of chronic asthma, is a leukotriene receptor antagonist. The psychiatric side effects of montelukast use in asthma patients are controversial. The aim of this study is to examine
Ersoz Gonca
doaj +1 more source
Is It Safe to Reduce Inhaled Corticosteroid Dose in Severe Asthma Patients Receiving Biologic Therapy? [PDF]
Clin Transl AllergyABSTRACT Background Biologic therapies can control severe asthma and may modify its natural history beyond symptom control. However, step‐down is not standardized, and its safety has not been clearly established. Methods This single‐center retrospective cohort study reviewed adults with severe asthma on biologics (January 2019–May 2024).
Özer N +4 more
europepmc +2 more sources
The examination of the nephroprotective effect of montelukast sodium and N-acetylcysteine ın renal ıschemia with dimercaptosuccinic acid imaging in a placebo-controlled rat model [PDF]
Acta Cirúrgica Brasileira, 2020 Purpose To determine the nephroprotective effect of NAC and Montelukast Sodium administration against the development of renal damage associated with long warm renal ischemia.
Arif Aydin +9 more
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Neuropsychiatric events associated with montelukast in patients with asthma: a systematic review
European Respiratory Review, 2023 Background: The United States Food and Drug Administration issued a black box warning on the mental health adverse effects of montelukast in 2020. Age-related effects on the risk of developing specific neuropsychiatric events in montelukast users remain ...
Chris Wai Hang Lo +8 more
doaj +1 more source
Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure. [PDF]
Clin Pharmacol TherThis study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Mykkänen AJH +14 more
europepmc +2 more sources
In vitro cytotoxicity of montelukast in HAPI and SH-SY5Y cells
, 2020 Montelukast is a cysteinyl leukotriene (CysLT) receptor antagonist with efficacy against a variety of diseases, including asthma and inflammation-related conditions.
McFarland, Amelia J +8 more
core +1 more source
Analysis of neuropsychiatric diagnoses after montelukast initiation [PDF]
, 2022 Importance The evidence base for the association between montelukast and adverse neuropsychiatric outcomes is mixed and inconclusive. Several methodological limitations have been identified in the evidence base on the safety of montelukast in ...
Herttua, Kimmo +9 more
core +1 more source
Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury
Frontiers in Pharmacology, 2019 Acetaminophen (APAP) is a widely used over-the-counter antipyretic and analgesic drug. Overdose of APAP is the leading cause of hospital admission for acute liver failure.
Shiyun Pu +9 more
doaj +1 more source