Results 21 to 30 of about 13,200 (163)

A systematic review and meta-analysis of loratadine combined with montelukast for the treatment of allergic rhinitis

Frontiers in Pharmacology, 2023
Background: Loratadine and montelukast are clinical first-line drugs in the treatment of allergic rhinitis (AR). However, there is no clear evidence of the efficacy of loratadine combined with montelukast in the treatment of AR.
Huan Wang, Huan Wang, Qing Ji, Chao Liao, Li Tian   +4 more
doaj   +1 more source

Montelukast does not increase the risk of attention-deficit/hyperactivity disorder in pediatric asthma patients: A nationwide population-based matched cohort study

Journal of the Formosan Medical Association, 2021
Background: Attention-deficit/hyperactivity disorder (ADHD) has been linked to pediatric asthma patients treated with montelukast. This study is the first to use a nationwide health insurance research database (NHIRD) to study whether asthmatic children ...
Po-Yu Huang, Yao-Hsu Yang, Ying-Hua Huang, Ho-Chang Kuo, Liang-Jen Wang, Shao-Ju Chien, Ling-Sai Chang   +6 more
doaj   +1 more source

Neuropsychiatric Adverse Events of Montelukast: An Analysis of Real-World Datasets and drug−gene Interaction Network

Frontiers in Pharmacology, 2021
Montelukast is a selective leukotriene receptor antagonist that is widely used to treat bronchial asthma and nasal allergy. To clarify the association between montelukast and neuropsychiatric adverse events (AEs), we evaluated case reports recorded ...
Ryogo Umetsu, Mizuki Tanaka, Yoko Nakayama, Yamato Kato, Natsumi Ueda, Yuri Nishibata, Shiori Hasegawa, Kiyoka Matsumoto, Noriaki Takeyama, Kazuhiro Iguchi, Hiroyuki Tanaka, Eiichi Hinoi, Eiichi Hinoi, Naoki Inagaki, Masatoshi Inden, Yoshinori Muto, Mitsuhiro Nakamura   +16 more
doaj   +1 more source

Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS

Indonesian Journal of Pharmacy, 2020
A simple, rapid and sensitive simultaneous method for validation and determination of Montelukast in rat plasma in the presence of grape and licorice juices has been done by using High Performance Liquid Chromatography–Mass Spectrometry (HPLC/MS).
Mohammed Hamad, Rafif Raad, Eyad Mallah, Zainab Zakaria, Tawfiq Arafat, Wael Abu Dayyih   +5 more
doaj   +1 more source

Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells

Frontiers in Pharmacology, 2022
Background: Epithelial-mesenchymal transition (EMT) of airway lung epithelial cells is considered a major driver of fibrosis and airway remodeling. Arsenic exposure is well known to cause the malignant transformation of cells, including those in the lung.
Huang-Chi Chen, Huang-Chi Chen, Hsin-Ying Clair Chiou, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Mei-Lan Tsai, Szu-Chia Chen, Szu-Chia Chen, Szu-Chia Chen, Ming-Hong Lin, Ming-Hong Lin, Ming-Hong Lin, Ming-Hong Lin, Tzu-Chun Chuang, Chih-Hsing Hung, Chih-Hsing Hung, Chih-Hsing Hung, Chih-Hsing Hung, Chao-Hung Kuo, Chao-Hung Kuo, Chao-Hung Kuo   +20 more
doaj   +1 more source

Safety, Efficacy, and Mechanism of Action of Budesonide in Rhinitis and Rhinosinusitis: A Systematic Review. [PDF]

World J Otorhinolaryngol Head Neck Surg
ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and ...
Kennedy DW, Cheng L, Wang DY.
europepmc   +2 more sources

Montelukast Use Decreases Cardiovascular Events in Asthmatics [PDF]

, 2021
Cysteinyl leukotrienes are proinflammatory mediators with a clinically established role in asthma and a human genetic and preclinical role in cardiovascular pathology.
Hoxha M., Sala A., Evans J. F., Tedesco C. C., Pustina L., Rovati G. E., Quaglini S., Capra V., Malaj V., G. Enrico Rovati, Hoxha, Malvina, Sala, Angelo, Malvina Hoxha, Linda Pustina, Silvana Quaglin, Evans, Jilly F, Pustina, Linda, Angelo Sala, Tedesco, Calogero C, Valerie Capra, Capra, Valerie, Malaj, Visar, Rovati, G, Quaglin, Silvana, Calogero C. Tedesco, Jilly F. Evans, Visar Malaj   +26 more
core   +2 more sources

Evaluation of the Developmental Parameters, Behavioral Outcomes and Brain Histology in Rats After Exposure to Montelukast

The Egyptian Journal of Histology, 2023
Introduction: Montelukast is a leukotriene receptor antagonist. Because of warnings by the US Food and Drug Administration to avoid using montelukast, the effect of early postnatal exposure to montelukast on several factors affecting rats was ...
luma Al Allaf, Sara Mohammed
doaj   +1 more source

The effect of montelukast, a leukotriene receptor antagonist, on the acetic acid-induced model of colitis in rats: Involvement of NO-cGMP-KATP channels pathway

Frontiers in Pharmacology, 2022
Inflammatory bowel disease is a chronic autoimmune disorder that may involve entire gastrointestinal tract. The leukotrienes have a role as mediators in the pathophysiology of colitis. Here, we investigated the effect of a leukotriene receptor antagonist,
Behnam Ghorbanzadeh, Mohammad Amin Behmanesh, Roya Mahmoudinejad, Mehdi Zamaniyan, Shadi Ekhtiar, Yousef Paridar   +5 more
doaj   +1 more source

Montelukast, an Antagonist of Cysteinyl Leukotriene Signaling, Impairs Burn Wound Healing [PDF]

, 2022
BACKGROUND: Burns are severe injuries often associated with impaired wound healing. Impaired healing is caused by multiple factors, including dysregulated inflammatory responses at the wound site.
Athena M. Soulika, Marilyn Wang, Shannon Yee, Shen, Haitao, Soulika, Athena M, Glendalyn Smith, Wang, Marilyn, Bagood, Michelle D, R. Rivkah Isseroff, Nguyen, Alan V, Isseroff, R Rivkah, Alan V. Nguyen, Smith, Glendalyn, Yee, Shannon, Caryotakis, Sofia E, Haitao Shen, Sofia E. Caryotakis, Michelle D. Bagood   +17 more
core   +1 more source