Results 21 to 30 of about 617,785 (192)

Analysis of the interventional effects of ambroxol hydrochloride and ontelukast sodium combined with azithromycin on immune function and C-reactive protein serum expression in children with severe Mycoplasma pneumoniae pneumonia [PDF]

Frontiers in Pediatrics
ObjectiveThe aim of the study was to investigate the clinical effects of ambroxol hydrochloride and montelukast sodium combined with azithromycin on immune function, inflammatory cytokines, and pulmonary function in children with severe Mycoplasma ...
Xueru Liu, Xiang Chen, Shan Ye
doaj   +2 more sources

Loss of OXGR1 function uncouples intrarenal RAS activation from pendrin and αENaC regulation and blunts angiotensin II-induced hypertension [PDF]

Frontiers in Pharmacology
BackgroundActivation of the intrarenal renin–angiotensin system (RAS) is a key mechanism driving sodium retention and hypertension. In the distal nephron, locally generated angiotensin II (Ang II) promotes Na+ reabsorption through coordinated regulation ...
Pilar Cárdenas, Juan Castillo-Geraldo, Lilian Caroline Gonçalves de Oliveira, Nicolas Muñoz, Rodrigo Yokota, Marina de Moura Bello, Gabriel Joo-Mulsow, Luis Michea, Dulce Elena Casarini, Alexis A. Gonzalez, Alexis A. Gonzalez   +10 more
doaj   +2 more sources

Development of stability-indicating HPLC-UV method and oxidative degradation kinetic study of montelukast in chewable tablet formulation

Pakistan Journal of Pharmaceutical Sciences, 2021
A simple and sensitive stability-indicating HPLC-UV method was developed and validated for the determination of montelukast in the development of chewable tablet formulation.
Emily Yii Ling Wong, Gabriel Onn Kit Loh, Kok Khiang Peh   +2 more
doaj   +1 more source

Montelukast sodium in cystic fibrosis [PDF]

Thorax, 2001
Many older patients with cystic fibrosis (CF) describe a component of their condition as “asthma” despite a lack of objective bronchial lability. We undertook a therapeutic trial of the leukotriene antagonist montelukast sodium in one such patient and observed a marked improvement in symptoms and peak expiratory flow rate (PEFR).
A H, Morice, J A, Kastelik, I, Aziz
openaire   +2 more sources

Effects of oral cysteine leukotriene receptor antagonist-montelukast on adenoid lymphoid tissue: a histopathological study under light microscope

Frontiers in Pharmacology, 2023
Background: Adenoidal hypertrophy (AH) is one of the most common causes of upper airway obstruction in children. Drug and surgical treatment are the typical treatment of AH.
Zhengying Wang, Zhengying Wang, Xiuling Wu, Xiuling Wu, Jinghong Liu, Jinghong Liu, Yu Wang, Yu Wang, Yue Zhang, Yan Wu, Yingxue Kang, Yingxue Kang, Ronghai Zhang, Ronghai Zhang, Jin Li, Jin Li, Delong Liu   +16 more
doaj   +1 more source

Non-obvious effects of montelukast – leukotriene receptor blocker: frigoprotective and anticonvulsant properties

Medičnì Perspektivi, 2021
The participation of arachidonic acid metabolism products – prostaglandins and leukotrienes – in the process of inflammation is a common pathogenetic link of cold injury and epilepsy.
S.Yu. Shtrygol , I.G. Kapelka, M.V. Mishchenko , O.Ya. Mishchenko   +3 more
doaj   +1 more source

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

eLife, 2022
The SARS-CoV-2 non-structural protein 1 (Nsp1) contains an N-terminal domain and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 (Nsp1-C-ter) from SARS-CoV-2 bind in the mRNA entry channel of the 40S ribosomal ...
Mohammad Afsar, Rohan Narayan, Md Noor Akhtar, Deepakash Das, Huma Rahil, Santhosh Kambaiah Nagaraj, Sandeep M Eswarappa, Shashank Tripathi, Tanweer Hussain   +8 more
doaj   +1 more source

Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells

Frontiers in Pharmacology, 2022
Background: Epithelial-mesenchymal transition (EMT) of airway lung epithelial cells is considered a major driver of fibrosis and airway remodeling. Arsenic exposure is well known to cause the malignant transformation of cells, including those in the lung.
Huang-Chi Chen, Huang-Chi Chen, Hsin-Ying Clair Chiou, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Mei-Lan Tsai, Szu-Chia Chen, Szu-Chia Chen, Szu-Chia Chen, Ming-Hong Lin, Ming-Hong Lin, Ming-Hong Lin, Ming-Hong Lin, Tzu-Chun Chuang, Chih-Hsing Hung, Chih-Hsing Hung, Chih-Hsing Hung, Chih-Hsing Hung, Chao-Hung Kuo, Chao-Hung Kuo, Chao-Hung Kuo   +20 more
doaj   +1 more source

Randomized Controlled Trial of Fish Oil and Montelukast and Their Combination on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction [PDF]

, 2010
Both fish oil and montelukast have been shown to reduce the severity of exercise-induced bronchoconstriction (EIB). The purpose of this study was to compare the effects of fish oil and montelukast, alone and in combination, on airway inflammation and ...
Louise A Turner, Turner Louise A., Mickleborough, Timothy D., Joel M Stager, Gregory S. Montgomery, Montgomery, Gregory, Tecklenburg-Lund, Sandra, Turner, Louise A., Montgomery, Gregory S., Alyce D. Fly, Joel M. Stager, Timothy D Mickleborough, Fly, Alyce D., Stager, Joel M., Fly, Alyce, Stager Joel M., Montgomery Gregory S., Mickleborough Timothy D., Timothy D. Mickleborough, Mickleborough, Timothy, Tecklenburg-Lund Sandra, Gregory S Montgomery, Stager, Joel, Louise A. Turner, Fly Alyce D., Turner, Louise, Sandra Tecklenburg-Lund, Alyce D Fly   +27 more
core   +2 more sources

Experimental study on montelukast sodium inducing apoptosis in multiple myeloma cells via targeting intracellular USP2 protein [PDF]

Zhongguo aizheng zazhi
Background and purpose: Intracellular deubiquitylating enzymes, such as ubiquitin-specific peptidase 2 (USP2), play a pivotal role in regulating protein degradation and cellular homeostasis by modulating protein ubiquitin deconjugation, which have been ...
DU Chengrong, WANG Yingying, TANG Yong, YAO Yiyun, WU Yingli, ZHU Qi
doaj   +1 more source