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New Therapeutic Targets for Mood Disorders [PDF]
The Scientific World Journal, 2010 Existing pharmacological treatments for bipolar disorder (BPD) and major depressive disorder (MDD) are often insufficient for many patients. Here we describe a number of targets/compounds that clinical and preclinical studies suggest could result in ...
Rodrigo Machado-Vieira +8 more
doaj +2 more sources
Brain Structure and Function, 2008 The neural networks that putatively modulate aspects of normal emotional behavior have been implicated in the pathophysiology of mood disorders by converging evidence from neuroimaging, neuropathological and lesion analysis studies.
W. Drevets, J. Price, M. Furey
exaly +2 more sources
Brain Sciences, 2021 The COVID-19 pandemic has resulted in a predominantly global quarantine response that has been associated with social isolation, loneliness, and anxiety.
Linas Wilkialis +9 more
doaj +1 more source
JAMA psychiatry, 2021 Importance Preexisting noncommunicable diseases (eg, diabetes) increase the risk of COVID-19 infection, hospitalization, and death. Mood disorders are associated with impaired immune function and social determinants that increase the risk of COVID-19 ...
Felicia Ceban +17 more
semanticscholar +1 more source
The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment
Frontiers in Psychiatry, 2021 Mitochondria are cellular organelles involved in several biological processes, especially in energy production. Several studies have found a relationship between mitochondrial dysfunction and mood disorders, such as major depressive disorder and bipolar ...
Anna Giménez-Palomo +8 more
semanticscholar +1 more source
BMC Pregnancy and Childbirth, 2022 Background Perinatal mental health problems are prevalent, affecting up to 20% of women However, only 17–25% receive formal support during the perinatal period.
Chloe Rice +2 more
doaj +1 more source
Neuroinflammation in Mood Disorders: Role of Regulatory Immune Cells
Neuroimmunomodulation, 2021 Mood disorders are associated with chronic low-grade systemic (sterile) inflammation, with increased plasma levels of pro-inflammatory mediators targeting all tissues including the brain.
M. Bauer, A. Teixeira
semanticscholar +1 more source
Clinical efficacy and tolerability of Esketamine: a case series
European Psychiatry, 2022 Introduction Esketamine is a novel antidepressant approved by the FDA in 2019 in the form of an intranasal spray, recommended for Treatment-Resistant Depression (TRD).
C. Passani +6 more
doaj +1 more source
Differences between bipolar disorder types 1 and 2 support the DSM two-syndrome concept
International Journal of Bipolar Disorders, 2022 Objective To compare characteristics of bipolar disorder patients diagnosed as DSM-5 types I (BD-1) vs. II (BD-2). Methods We compared descriptive, psychopathological, and treatment characteristics in a sample of 1377 consenting, closely and repeatedly ...
Leonardo Tondo +4 more
doaj +1 more source
Frontiers in Psychiatry, 2021 Purpose: This study examines health literacy among older outpatients in two Community Healthcare Service Centers in Shanghai, China to facilitate the design of public education programs for the aged population on mood disorders (both depression and mania)
Leping Huang +13 more
doaj +1 more source