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New Therapeutic Targets for Mood Disorders [PDF]

The Scientific World Journal, 2010
Existing pharmacological treatments for bipolar disorder (BPD) and major depressive disorder (MDD) are often insufficient for many patients. Here we describe a number of targets/compounds that clinical and preclinical studies suggest could result in ...
Rodrigo Machado-Vieira, Giacomo Salvadore, Nancy DiazGranados, Lobna Ibrahim, David Latov, Cristina Wheeler-Castillo, Jacqueline Baumann, Ioline D. Henter, Carlos A. Zarate   +8 more
doaj   +2 more sources

Social Isolation, Loneliness and Generalized Anxiety: Implications and Associations during the COVID-19 Quarantine

Brain Sciences, 2021
The COVID-19 pandemic has resulted in a predominantly global quarantine response that has been associated with social isolation, loneliness, and anxiety.
Linas Wilkialis, Nelson B. Rodrigues, Danielle S. Cha, Ashley Siegel, Amna Majeed, Leanna M. W. Lui, Jocelyn K. Tamura, Barjot Gill, Kayla Teopiz, Roger S. McIntyre   +9 more
doaj   +1 more source

A qualitative study of the impact of peer support on women’s mental health treatment experiences during the perinatal period

BMC Pregnancy and Childbirth, 2022
Background Perinatal mental health problems are prevalent, affecting up to 20% of women However, only 17–25% receive formal support during the perinatal period.
Chloe Rice, Emma Ingram, Heather O’Mahen   +2 more
doaj   +1 more source

Clinical efficacy and tolerability of Esketamine: a case series

European Psychiatry, 2022
Introduction Esketamine is a novel antidepressant approved by the FDA in 2019 in the form of an intranasal spray, recommended for Treatment-Resistant Depression (TRD).
C. Passani, N. Ragone, C.M. Congedo, B. Barbini, R. Zanardi, M.C. Cavallini, C. Colombo   +6 more
doaj   +1 more source

Differences between bipolar disorder types 1 and 2 support the DSM two-syndrome concept

International Journal of Bipolar Disorders, 2022
Objective To compare characteristics of bipolar disorder patients diagnosed as DSM-5 types I (BD-1) vs. II (BD-2). Methods We compared descriptive, psychopathological, and treatment characteristics in a sample of 1377 consenting, closely and repeatedly ...
Leonardo Tondo, Alessandro Miola, Marco Pinna, Martina Contu, Ross J. Baldessarini   +4 more
doaj   +1 more source

Lower Health Literacy of Mania Than Depression Among Older People: A Random Survey of a Community Healthcare Service Center

Frontiers in Psychiatry, 2021
Purpose: This study examines health literacy among older outpatients in two Community Healthcare Service Centers in Shanghai, China to facilitate the design of public education programs for the aged population on mood disorders (both depression and mania)
Leping Huang, Ruyan Huang, Yue Fei, Taosheng Liu, David Mellor, Weiyun Xu, Jinxia Xiong, Rongjie Mao, Jun Chen, Yiru Fang, Zhiguo Wu, Zuowei Wang, Zuowei Wang, Zuowei Wang   +13 more
doaj   +1 more source

Reliability and validity of the Chinese version of the biological rhythms interview of assessment in neuropsychiatry in patients with major depressive disorder

BMC Psychiatry, 2022
Background Although disturbances in biological rhythms are closely related to the onset of major depressive disorder (MDD), they are not commonly assessed in Chinese clinical practice.
Shen He, Lei Ding, Kaibing He, Baoying Zheng, Dan Liu, Min Zhang, Yao Yang, Yingqun Mo, Hua Li, Yiyun Cai, Daihui Peng   +10 more
doaj   +1 more source

Reducing worry and rumination in young adults via a mobile phone app: study protocol of the ECoWeB (Emotional Competence for Well-Being in Young Adults) randomised controlled trial focused on repetitive negative thinking

BMC Psychiatry, 2021
Background Promoting well-being and preventing poor mental health in young people is a major global priority. Building emotional competence skills via a mobile app may be an effective, scalable and acceptable way to do this.
Daniel Edge, Alexandra Newbold, Thomas Ehring, Tabea Rosenkranz, Mads Frost, Edward R. Watkins   +5 more
doaj   +1 more source

The Role of Ketamine in the Treatment of Bipolar Depression: A Scoping Review

Brain Sciences, 2023
Bipolar depression remains a clinical challenge with a quarter of patients failing to respond to initial conventional treatments. Although ketamine has been extensively studied in unipolar depression, its role in bipolar disorder remains inconclusive ...
Muhammad Youshay Jawad, Saleha Qasim, Menglu Ni, Ziji Guo, Joshua D. Di Vincenzo, Giacomo d’Andrea, Aniqa Tabassum, Andrea Mckenzie, Sebastian Badulescu, Iria Grande, Roger S. McIntyre   +10 more
doaj   +1 more source

Neurodegeneration in the centrally-projecting Edinger–Westphal nucleus contributes to the non-motor symptoms of Parkinson’s disease in the rat

Journal of Neuroinflammation, 2022
Background The neuropathological background of major depression and anxiety as non-motor symptoms of Parkinson’s disease is much less understood than classical motor symptoms. Although, neurodegeneration of the Edinger–Westphal nucleus in human Parkinson’
Balázs Ujvári, Bence Pytel, Zsombor Márton, Máté Bognár, László Ákos Kovács, József Farkas, Tamás Gaszner, Gergely Berta, Angéla Kecskés, Viktória Kormos, Boglárka Farkas, Nóra Füredi, Balázs Gaszner   +12 more
doaj   +1 more source