Results 181 to 190 of about 1,649 (211)
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Synthesis of aminothiazole derived morphinans
Tetrahedron Letters, 2003Two aminothiazole derived morphinans 9 and 11 were prepared for our ongoing opioid ligands study. The synthesis was initiated from levorphanol 1, which was first triflated, and then subjected to Pd-catalyzed reduction followed by nitration. The resulting two nitrated isomers were characterized by analogy to known compounds.
Ao Zhang +2 more
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Syntheses of Pentacyclic Morphinan Analogs
Canadian Journal of Chemistry, 1975The synthesis of a series of morphinans with an additional aromatic or alicyclic ring fused to the 5,6 positions or an alicyclic ring fused to the 16,17 positions is described. The synthetic sequence involved elaboration of a 1,2,3,4,5,6-hexahydrobenz[f]isoquinoline or a quinolizidine, Grewe cyclization to a morphinan, and modification of the ...
James L. Douglas, Jacques Meunier
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Chemistry and biology of ent-morphinan alkaloids
2023Morphinan alkaloids have attracted constant attention since the isolation of morphine by Sertürner in 1805. However, a group of 45 compounds possessing a complete ent-morphinan backbone can also be found in the literature. These compounds are related to the morphinandienone subgroup and display a substitution pattern which is different from the ...
Keita, Antoinette +2 more
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Chemische Berichte, 1951
AbstractN‐Phenacetyl‐β‐cyclohexenyl‐äthylamin, welches sich nach Schnider und Hellerbach in die „Vorstufe”︁ und damit in Morphinan überführen läßt, wird auf einem neuen Wege auf der Basis von Cyclohexanon und Acetylen aufgebaut.
Rudolf Grewe +2 more
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AbstractN‐Phenacetyl‐β‐cyclohexenyl‐äthylamin, welches sich nach Schnider und Hellerbach in die „Vorstufe”︁ und damit in Morphinan überführen läßt, wird auf einem neuen Wege auf der Basis von Cyclohexanon und Acetylen aufgebaut.
Rudolf Grewe +2 more
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Aporphine and Morphinan Alkaloids
1968The aporphine and morphinan alkaloids can be conveniently considered together because they often occur together in the same plant, and also because in terms of structure they can both be derived from a benzylisoquinoline skeleton by additional ring closures:
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Morphinane Alkaloid Dimers from Sinomenium acutum
Journal of Natural Products, 2007Two new morphinane alkaloid dimers, 2,2'-disinomenine (1) and 7',8'-dihydro-1,1'-disinomenine (2), and known 1, 1'-disinomenine (3), were isolated from ethanol extracts of stems of Sinomenium acutum. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of alkaloids 1-3 was determined by direct comparison of
Hui-Zi, Jin +6 more
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Etorphine‐Related Ferrocenyl‐Substituted Morphinan Alkaloids
Helvetica Chimica Acta, 2003AbstractThe two diastereoisomeric ferrocenyl‐substituted orvinols 2 and 3 were prepared. The modified alkaloids are still able to interact with opioid receptors (see Table). The ferrocene moiety allows highly selective and sensitive electrochemical detection. The X‐ray crystal structure of the major isomer 2 was determined.
Gerhard Laus +8 more
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Two new morphinane alkaloids from Sinomenium acutum
Journal of Asian Natural Products Research, 2011Two new morphinane alkaloids, 1-hydroxy-10-oxo-sinomenine (1) and 4,5-epoxy-14-hydroxy sinomenine N-oxide (2), have been isolated from the stems of Sinomenium acutum. Their structures were established by various spectral analyses, especially 2D NMR experiments. The structure of 2 was confirmed by single crystal X-ray diffraction.
Xiao-Ling, Wang +5 more
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Synthesis of Sulfur-Containing Morphinane Dienes
Synthetic Communications, 1995Abstract 6- and 7-thiocyanato derivatives of 6-demethoxythebaine were obtained by nucleophilic substitution and elimination reactions of 14-halogenated codeine tosylate.
Sándor Berényi +3 more
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Biosynthesis of Morphinan Alkaloids
1985By the turn of the century a large number of alkaloids had been isolated, and investigators began to turn their attention to the ways by which these natural products were constructed in the living plant. Many interesting ideas were proposed during the next decades.
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