Results 91 to 100 of about 235,160 (357)

Ueber Morphin [PDF]

Berichte der deutschen chemischen Gesellschaft, 1882
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von Gerichten, E., Schrötter, Hugo
openaire   +2 more sources

Blockade of Toll-Like Receptor 4 Attenuates Morphine Tolerance and Facilitates the Pain Relieving Properties of Morphine

Journal of Neuroscience, 2013
The ventrolateral periaqueductal gray (vlPAG) is an integral locus for morphine action. Although it is clear that glia contribute to the development of morphine tolerance, to date, the investigation of their role has been limited to spinal and medullary ...
Lori N. Eidson, A. Murphy
semanticscholar   +1 more source

Antinociceptive and Anti‐inflammatory Effect of Nicandrin B Isolated From Datura ferox in Zebrafish

Chemistry &Biodiversity, EarlyView.
ABSTRACT Nicandrin B (Nic B), a withanolide isolated from Datura ferox leaves, was investigated for its antinociceptive and anti‐inflammatory effects in adult zebrafish (Danio rerio). Animals treated with Nic B (4, 20, and 40 mg/kg) showed no toxicity and maintained normal locomotor activity.
Jéssica Bezerra Maciel, Hortência Ribeiro Liberato, Antônio Wlisses da Silva, Maria Auxiliadora Solange Silva Gondim Pereira, Emanuela de Lima Rebouças, Francisco das Chagas L. Pinto, Matheus Nunes da Rocha, Maria Kueirislene Amâncio Ferreira, Janaina Serra Azul Monteiro Evangelista, Izabel Florindo Guedes, Marcia Machado Marinho, Emmanuel Silva Marinho, Andreia Ferreira de Castro Gomes, Otília Loiola Pessoa, Jane Eire Silva Alencar de Menezes, Hélcio Silva dos Santos   +15 more
wiley   +1 more source

PKC-Mediated Potentiation of Morphine Analgesia by St. John’s Wort in Rodents and Humans

Journal of Pharmacological Sciences, 2014
Our purpose was to combine the use of morphine with clinically available inhibitors of protein kinase C (PKC), finally potentiating morphine analgesia in humans.
Nicoletta Galeotti, Mersedeh Farzad, Enrica Bianchi, Carla Ghelardini   +3 more
doaj   +1 more source

Novel Insights Into the Bioactive Profile and Therapeutic Potentials of Indonesian Annona muricata Leaves

Chemistry &Biodiversity, EarlyView.
Pharmacological investigation of the aqueous extract of Annona muricata L. leaves from Indonesia. ABSTRACT This study investigates, for the first time, the comprehensive pharmacological profile of the aqueous extract of Annona muricata L. (graviola) leaves from Indonesia, focusing on its antioxidant, antinociceptive, and anti‐inflammatory properties ...
Sara Oufquir, Fatimazahra Agouram, Hamid Kabdy, Mehdi Ait Laaradia, Khadija Oubella, Baslam Abdelmoniim, Aboufatima Rachida, Stefania Garzoli, Abderrahman Chait   +8 more
wiley   +1 more source

Evaluation of the Drug–Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling

Pharmaceutics
Background: Morphine is a commonly prescribed opioid analgesic used to treat chronic pain. Morphine undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7 to form morphine-3-glucuronide and morphine-6-glucuronide.
Shelby Coates, Keti Bardhi, Bhagwat Prasad, Philip Lazarus   +3 more
doaj   +1 more source

Adolescent Morphine Exposure Affects Long-Term Microglial Function and Later-Life Relapse Liability in a Model of Addiction

Journal of Neuroscience, 2013
Adolescence in humans represents a unique developmental time point associated with increased risk-taking behavior and experimentation with drugs of abuse.
J. Schwarz, S. Bilbo
semanticscholar   +1 more source

Results of the ACCOuNT Trial: A Multi‐Institutional Prospective Pharmacogenomics Implementation Trial for African American Inpatients

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomics implementation efforts have increased over the last decade, but no published prospective pharmacogenomics trials have formally evaluated utility in underrepresented populations. We present final results from the ACCOuNT trial, a multi‐institutional prospective study [NCT03225820] in which African American inpatients were genotyped and ...
Zhong Huang, Kevin J. O'Leary, Edith A. Nutescu, Matthew Jack, Thomas Chen, Gregory W. Ruhnke, James C. Lee, David George, Larry K. House, Randall Knoebel, Luke V. Rasmussen, Seth Hartman, Anish Choksi, Kiang‐Teck J. Yeo, Minoli A. Perera, Mark J. Ratain, David O. Meltzer, Peter H. O'Donnell   +17 more
wiley   +1 more source

Effects of Isoniazid on Tolerance and Sensitization to the Rewarding Properties of Morphine: A Conditioned Place Preference Procedure Investigation in Mice

Basic and Clinical Neuroscience, 2020
Introduction: The GABAergic system of the brain plays a key role in morphine tolerance and sensitization. As isoniazid is a modulator of the GABAergic system, the present study aims to understand whether isoniazid can influence the induction of tolerance
Amir Abbas Barzegari, Kamran Shahabi
doaj  

Morphine as a Potential Oxidative Stress-Causing Agent

Mini-Reviews in Organic Chemistry, 2013
Morphine exhibits important pharmacological effects for which it has been used in medical practice for quite a long time. However, it has a high addictive potential and can be abused.
Jitka Škrabalová, Z. Drastichova, J. Novotný   +2 more
semanticscholar   +1 more source