Results 91 to 100 of about 339,726 (399)

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård, Lotte Rasmussen, Morten Olesen, Anne Mette Skov Sørensen, Zandra Nymand Ennis, Joseph Kane, Sarah Baxter, Blánaid Hicks   +7 more
wiley   +1 more source

Sleep quality and quantity determined by polysomnography in mechanically ventilated critically ill patients randomized to dexmedetomidine or placebo

Acta Anaesthesiologica Scandinavica, Volume 67, Issue 1, Page 66-75, January 2023., 2023
Abstract Background Abnormal sleep is commonly observed in the ICU and is associated with delirium and increased mortality. If sedation is necessary, it is often performed with gamma‐aminobutyric acid agonists such as propofol or midazolam leading to an absence of restorative sleep.
Jakob Oxlund, Torben Knudsen, Mikael Sörberg, Thomas Strøm, Palle Toft, Poul Jørgen Jennum   +5 more
wiley   +1 more source

The Effect of Memantine on the Expression of Dopamine Receptors in the Striatum of Male Rats With Morphine Addiction [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2023
Background and Objectives: Studies have indicated that the chronic use of morphine can result in physical and psychological dependence. Morphine dependence is associated with several cellular and molecular alterations in the mesocorticolimbic system, and
Sahar Khalili Samani, Solmaz Khalifeh, Mehdi Vahiddastjerdi, Mandana Hassanzad, Afshin Kheradmand, Farzaneh Nazari Serenjeh   +5 more
doaj  

DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self‐administration in rats [PDF]

, 2019
Drug‐reinforced excessive operant responding is one fundamental feature of long-lasting addiction‐like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug‐specific (not natural rewards)
Duan, Ying, Jiang, Feng-Ze, Jin, Su-Bo, Li, Ming, Liang, Jing, Shen, Fang, Sui, Nan, Zhang, Jian-Jun, Zheng, Wei   +8 more
core   +1 more source

Ingested placenta blocks the effect of morphine on gut transit in Long–Evans rats [PDF]

, 2004
Opioids produce antinociception, and ingested placenta or amniotic fluid modifies that antinociception. More specifically, ingested placenta enhances the antinociception produced by selective activation of central n-opioid or y-opioid receptors but ...
Corpening, Dr. James W., Doerr, Dr. Jean C., Kristal, Dr. Mark B.   +2 more
core   +1 more source

Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)

Chemistry &Biodiversity, EarlyView.
This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni, Milena Costa Bassicheto, Maria Vitória de Oliveira, Ana Beatriz dos Santos de Souza, Gabriella Melo Alves, Thiago André Moura Veiga   +5 more
wiley   +1 more source

The Effect of Memory Reinforcement by Cholinergic Agonist and Music on Creating Morphine Dependency in Mice Using Conditioned Place Preference (CPP) Method

فصلنامه دانشگاه علوم پزشکی جهرم, 2013
The most important side effect of addictive drugs is their interaction with nervous system so that soon after taking the drug, the neurons̉ connections in nervous system are addicted to receiving the drugs frequently. The aim of this study was the effect
Eebrahim Hosseini, Mokhtar Mokhtari, Akbar Vahdati, Neamat Razmi, Farnaz Tavakoli   +4 more
doaj  

The gamma-aminobutyric acid type B (GABA_B) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens

Behavioral and Brain Functions, 2012
Background Repeated morphine exposure can induce behavioral sensitization. There are evidences have shown that central gamma-aminobutyric acid (GABA) system is involved in morphine dependence.
Fu Zhenyu, Yang Hongfa, Xiao Yuqiang, Zhao Gang, Huang Haiyan   +4 more
doaj   +1 more source

A novel behavioral fish model of nociception for testing analgesics [PDF]

, 2011
Pain is a major symptom in many medical conditions, and often interferes significantly with a person's quality of life. Although a priority topic in medical research for many years, there are still few analgesic drugs approved for clinical use.
Ana D. Correia, Ashley, Barrallo, Bowman, Braithwaite, Breivik, Breivik, Brunner, Chervova, Chervova, Chervova, Cunha, Dunlop, E. Don Stevens, Ehrensing, Friend, Gonzalez-Nunez, Herrero-Turrion, Le Bars, Mansour, Martin Scholze, Matthes, Newby, Newby, Newby, Nordgreen, Nordgreen, Reilly, Ribeiro, Ribeiro, Sanchez-Simon, Sneddon, Sneddon, Sneddon, Sneddon, Sneddon, Stevens, Stevens, Sérgio R. Cunha, Tukey, Wheeler-Aceto, Zon   +41 more
core   +3 more sources

Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial

Canadian Medical Association Journal, 2014
Background: Recent warnings from Health Canada regarding codeine for children have led to increased use of nonsteroidal anti-inflammatory drugs and morphine for common injuries such as fractures.
N. Poonai, G. Bhullar, K. Lin, Adam Papini, D. Mainprize, J. Howard, J. Teefy, M. Bale, Cindy Langford, R. Lim, L. Stitt, M. Rieder, Samina Ali   +12 more
semanticscholar   +1 more source