Results 111 to 120 of about 176,329 (291)
Medicinal Research Reviews, EarlyView.ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu +15 more
wiley +1 more source
Basic and Clinical Neuroscience, 2013 Introduction: Calcium/calmodulin-dependent protein kinase II (CaMKII) is highly expressed in the hippocampus, which has a pivotal role in reward-related memories and morphine dependence.
Shamseddin Ahmadi +3 more
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The Use of Intravenous Clonidine in Postoperative Pain Management: A Scoping Review. [PDF]
Acta Anaesthesiol ScandABSTRACT Background Clonidine, an alpha‐2 receptor agonist, has been explored as a potential analgesic in postoperative pain management, but its efficacy and safety profile remain unclear. The aim of this scoping review was to present the evidence on the use of intravenous clonidine in postoperative pain management.
Mohr T +4 more
europepmc +2 more sources
Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Neuroprotection, EarlyView.Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi +5 more
wiley +1 more source
, 2007 Previous studies demonstrated that drug cues could elicit drug-like or withdrawal-like effect, both subjectively and physiologically. However, few studies have compared the central activities induced by a drug-related environment and the drug itself. The
C. L. Cui +8 more
core +1 more source
Safety and Efficacy of the Versius Surgical System in Transoral Robotic Surgery: A Prospective Study
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective To evaluate the safety and feasibility of the Versius surgical robotic system for transoral robotic surgery in benign and malignant head and neck indications. Study Design Open‐label, prospective, single‐arm, phase II clinical trial. Setting Liverpool Head and Neck Centre, United Kingdom. Methods Between December 2023 and March 2025,
Jason C. Fleming +11 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai +6 more
wiley +1 more source
Morphine nitrate and morphine acetate
, 2006 n ...
Engelhardt, H., Winters, O. E.
openaire +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 551-560, March 2025.ABSTRACT Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21
Rebecca Silvola +9 more
wiley +1 more source
Changes in the Gene Expression of β1 and β2 Integrins Following Development of Tolerance to Analgesic Effect of Morphine in Rats [PDF]
Cell Journal, 2010 Objective: Considering the inhibitory effect of integrin-activity modulator (manganese) onthe development of morphine tolerance; in this study we have tried to assess the effectof chronic administration of both morphine and manganese on the expression ...
Jamal Ghorbi +2 more
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