Results 101 to 110 of about 265,062 (307)
Characterization of a Single Chain Fv Antibody that Reacts with Free Morphine
Antibodies, 2013 An immune phage library derived from mice, hyperimmunized with morphine-conjugated BSA, was used to isolate a single-chain Fv (scFv) clone, M86, with binding activity to morphine-conjugated thyroglobulin (morphine-C-Tg) but not to codeine-, cocaine-, or ...
Kazuhisa Sugimura +6 more
doaj +1 more source
Prenatal morphine exposure reduces pyramidal neurons in CA1, CA2 and CA3 subfields of mice hippocampus [PDF]
, 2014 Objective(s): This study was carried out to evaluate the effect of maternal morphine exposure during gestational and lactation period on pyramidal neurons of hippocampus in 18 and 32 day mice offspring.
Ghafari, S., Golalipour, M.J.
core +1 more source
The challenge of perioperative pain management in opioid-tolerant patients [PDF]
, 2017 The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals.
Bifulco, F +9 more
core +2 more sources
Pediatric Anesthesia, EarlyView.ABSTRACT Background Elective pediatric upper airway procedures are generally safe; however, some patients require unplanned pediatric intensive care unit admission, increasing care complexity. Aims To identify perioperative risk factors associated with unplanned pediatric intensive care unit admission following elective pediatric upper airway surgery ...
Hayes Stancliff +5 more
wiley +1 more source
Mitogen-Activated Protein Kinase Signaling Mediates Morphine Induced-Delayed Hyperalgesia
Frontiers in Neuroscience, 2019 The use of morphine, the standard opioid drug, is limited by its undesirable effects, such as tolerance, physical dependence, and hyperalgesia (increased pain sensitivity).
Bárbara Guimaraes de Freitas +6 more
doaj +1 more source
DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self‐administration in rats [PDF]
, 2019 Drug‐reinforced excessive operant responding is one fundamental feature of long-lasting addiction‐like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug‐specific (not natural rewards)
Duan, Ying +8 more
core +1 more source
PM&R, EarlyView.Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen +7 more
wiley +1 more source
Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential
Frontiers in PharmacologyMorphine has a crucial role in treating both moderate to severe pain and chronic pain. However, prolonged administration of morphine can lead to tolerance of analgesia, resulting in increased doses and poor treatment of pain. Many patients, such as those
Xiangning Zhang +9 more
doaj +1 more source
Direct and long-lasting effects elicited by repeated drug administration on 50-kHz ultrasonic vocalizations are regulated differently: Implications for the study of the affective properties of drugs of abuse [PDF]
, 2013 Several studies suggest that 50-kHz ultrasonic vocalizations (USVs) may indicate a positive affective state in rats, and these vocalizations are increasingly being used to investigate the properties of psychoactive drugs.
FRAU L +3 more
core +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai +6 more
wiley +1 more source